diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 98ff13787..3282b38c6 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -66,15 +66,15 @@ jobs:
         gdb --batch --quiet --nx --nh --ex 'py import rpyc; print(rpyc.version.version)'
 
     - name: Set up Python ${{ matrix.python_version }}
-      uses: actions/setup-python@v6
+      uses: astral-sh/setup-uv@v7
       with:
         python-version: ${{ matrix.python_version }}
-        cache: 'pip'
-        cache-dependency-path: |
+        enable-cache: true
+        activate-environment: true
+        cache-dependency-glob: |
           **/pyproject.toml
           **/requirements*.txt
 
-
     - name: Verify tag against version
       if: github.event_name == 'push' && startsWith(github.event.ref, 'refs/tags')
       env:
@@ -125,16 +125,13 @@ jobs:
 
     - name: Install dependencies
       run: |
-        pip install --upgrade pip
-        pip install --upgrade wheel build
-        pip install --upgrade flake8 appdirs
-        pip install --upgrade --editable .
+        uv pip install --upgrade --editable .
 
     - name: Sanity checks
       run:  PWNLIB_NOTERM=1 python -bb -c 'from pwn import *; print(pwnlib.term.term_mode)'
 
     - name: Install documentation dependencies
-      run: pip install -r docs/requirements.txt
+      run: uv pip install -r docs/requirements.txt
 
     - name: Disable yama ptrace_scope
       run: |
@@ -222,7 +219,7 @@ jobs:
 
     - name: Build source and wheel distributions
       run: |
-        python -m build
+        uv build
 
     - uses: actions/upload-artifact@v4
       if: matrix.python_version == '3.10'
@@ -251,11 +248,12 @@ jobs:
     - uses: actions/checkout@v5
 
     - name: Set up Python 3.12
-      uses: actions/setup-python@v6
+      uses: astral-sh/setup-uv@v7
       with:
         python-version: '3.12'
-        cache: 'pip'
-        cache-dependency-path: |
+        enable-cache: true
+        activate-environment: true
+        cache-dependency-glob: |
           **/pyproject.toml
           **/requirements*.txt
 
@@ -291,21 +289,18 @@ jobs:
 
     - name: Install dependencies
       run: |
-        pip install --upgrade pip
-        pip install --upgrade wheel build
-        pip install --upgrade flake8 appdirs
-        pip install --upgrade --editable .
+        uv pip install --upgrade --editable .
 
     - name: Sanity checks
       run:  PWNLIB_NOTERM=1 python -c 'from pwn import *; print(pwnlib.term.term_mode)'
 
     - name: Install documentation dependencies
-      run:  pip install -r docs/requirements.txt
+      run:  uv pip install -r docs/requirements.txt
 
     - name: Coverage Doctests (Android Only)
       run: |
         source .android.env
-        PWNLIB_NOTERM=1 coverage run -m sphinx -b doctest docs/source docs/build/doctest docs/source/adb.rst
+        PWNLIB_NOTERM=1 python -bb -m coverage run -m sphinx -b doctest docs/source docs/build/doctest docs/source/adb.rst
 
     - uses: actions/upload-artifact@v4
       with:
@@ -321,17 +316,21 @@ jobs:
     - uses: actions/checkout@v5
 
     - name: Set up Python 3.12
-      uses: actions/setup-python@v6
+      uses: astral-sh/setup-uv@v7
       with:
         python-version: '3.12'
+        enable-cache: true
+        activate-environment: true
+        cache-dependency-glob: |
+          **/pyproject.toml
+          **/requirements*.txt
 
     - name: Install dependencies
       run: |
-        pip install --upgrade pip
-        pip install --upgrade --editable .
+        uv pip install --upgrade --editable .
 
     - name: Install documentation dependencies
-      run: pip install -r docs/requirements.txt
+      run: uv pip install -r docs/requirements.txt
 
     - name: Sanity checks
       run: |
@@ -363,7 +362,7 @@ jobs:
 
     - name: Install coveralls
       run: |
-        pip install --break-system-packages tomli coveralls || pip install tomli coveralls
+        uv pip install tomli coveralls || pip install tomli coveralls
 
     - name: Upload coverage to coveralls.io
       run: |