diff --git a/.github/workflows/cicd.yml b/.github/workflows/cicd.yml index 17425c3..f41f227 100644 --- a/.github/workflows/cicd.yml +++ b/.github/workflows/cicd.yml @@ -7,9 +7,8 @@ on: branches: [main] release: types: [published] - -jobs: +jobs: format: runs-on: ubuntu-latest steps: @@ -36,25 +35,20 @@ jobs: runs-on: ubuntu-latest strategy: matrix: - python-version: [ - "3.9", - "3.10", - "3.11", - "3.12", - "3.13" - ] + python-version: ["3.9", "3.10", "3.11", "3.12", "3.13"] + fail-fast: false steps: - - uses: actions/checkout@v4 - - name: Set up Python ${{ matrix.python-version }} - uses: actions/setup-python@v5 - with: - python-version: ${{ matrix.python-version }} - - name: Install dependencies - run: | - pip install --upgrade pip - pip install ".[dev]" - - name: Test with pytest - run: python -m pytest tests + - uses: actions/checkout@v4 + - name: Set up Python ${{ matrix.python-version }} + uses: actions/setup-python@v5 + with: + python-version: ${{ matrix.python-version }} + - name: Install dependencies + run: | + pip install --upgrade pip + pip install ".[dev]" + - name: Test with pytest + run: python -m pytest tests build_source_dist: name: Build source distribution @@ -77,7 +71,6 @@ jobs: with: path: ./dist/*.tar.gz - publish: name: Publish package if: startsWith(github.ref, 'refs/tags') diff --git a/docs/api_examples/batch_correction.ipynb b/docs/api_examples/batch_correction.ipynb index 6974363..e53b581 100644 --- a/docs/api_examples/batch_correction.ipynb +++ b/docs/api_examples/batch_correction.ipynb @@ -43,8 +43,8 @@ "source": [ "from typing import Optional\n", "\n", + "import dsp_pandas\n", "import matplotlib.pyplot as plt\n", - "import numpy as np\n", "import pandas as pd\n", "import sklearn\n", "import sklearn.impute\n", @@ -55,11 +55,13 @@ "import acore.decomposition\n", "\n", "\n", - "def plot_umap(X_scaled, y, meta_column, random_state=42) -> plt.Axes:\n", + "def plot_umap(X_scaled, y, meta_column=None, random_state=42) -> plt.Axes:\n", " \"\"\"Fit and plot UMAP embedding with two components with colors defined by meta_column.\"\"\"\n", " embedding = acore.decomposition.umap.run_umap(\n", " X_scaled, y, random_state=random_state\n", " )\n", + " if meta_column is None:\n", + " meta_column = y.name\n", " ax = embedding.plot.scatter(\"UMAP 1\", \"UMAP 2\", c=meta_column, cmap=\"Paired\")\n", " return ax\n", "\n", @@ -94,7 +96,13 @@ " fig = vuecore.decomposition.pca_grid(\n", " PCs=PCs, meta_column=y, n_components=n_components, meta_col_name=meta_column\n", " )\n", - " return PCs, fig" + " return PCs, fig\n", + "\n", + "\n", + "dsp_pandas.format.set_pandas_options(\n", + " max_columns=9,\n", + " max_colwidth=20,\n", + ")" ] }, { @@ -117,23 +125,18 @@ }, "outputs": [], "source": [ - "fname_metadata: str = (\n", - " \"https://raw.githubusercontent.com/RasmussenLab/\"\n", - " \"njab/HEAD/docs/tutorial/data/alzheimer/meta.csv\" # clincial data\n", - ")\n", - "fname_omics: str = (\n", - " \"https://raw.githubusercontent.com/RasmussenLab/\"\n", - " \"njab/HEAD/docs/tutorial/data/alzheimer/proteome.csv\" # omics data\n", + "BASE = (\n", + " \"https://raw.githubusercontent.com/Multiomics-Analytics-Group/acore/\"\n", + " \"main/example_data/alzheimer_proteomics/\"\n", ")\n", - "METACOL: str = \"_collection site\" # target column in fname_metadata dataset (binary)\n", - "METACOL_LABEL: Optional[str] = \"site\" # optional: rename target variable\n", - "n_features_max: int = 5\n", - "freq_cutoff: float = 0.5 # Omics cutoff for sample completeness\n", - "VAL_IDS: str = \"\" #\n", - "VAL_IDS_query: str = \"\"\n", - "weights: bool = True\n", - "FOLDER = \"alzheimer\"\n", - "model_name = \"all\"" + "# data is already preprocessed: log2, filtered\n", + "fname: str = \"alzheimer_example_omics_and_clinic.csv\" # combined omics and meta data\n", + "covariates: list[str] = [\"age\", \"male\"]\n", + "group: str = \"collection_site\"\n", + "subject_col: str = \"Sample ID\"\n", + "drop_cols: list[str] = [\"AD\"]\n", + "factor_and_covars: list[str] = [group, *covariates]\n", + "group_label: Optional[str] = \"site\" # optional: rename target variable" ] }, { @@ -141,74 +144,41 @@ "id": "9bd7687c", "metadata": {}, "source": [ - "## Setup" - ] - }, - { - "cell_type": "markdown", - "id": "55b42bc2", - "metadata": {}, - "source": [ - "### Load proteomics (protein groups) data" + "## Data loading\n", + "Use combined dataset for ANCOVA analysis." ] }, { "cell_type": "code", "execution_count": null, - "id": "857b0522", - "metadata": {}, + "id": "ced30460", + "metadata": { + "tags": [ + "hide-input" + ] + }, "outputs": [], "source": [ - "if METACOL_LABEL is None:\n", - " METACOL_LABEL = METACOL\n", - "metadata = (\n", - " pd.read_csv(fname_metadata, usecols=[\"Sample ID\", METACOL], index_col=0)\n", + "omics_and_meta = (\n", + " pd.read_csv(f\"{BASE}/{fname}\", index_col=subject_col)\n", " .convert_dtypes()\n", - " .rename(columns={METACOL: METACOL_LABEL})\n", + " .dropna(subset=factor_and_covars)\n", ")\n", - "omics = pd.read_csv(fname_omics, index_col=0)" + "omics_and_meta" ] }, { "cell_type": "markdown", - "id": "4ad54348", - "metadata": {}, - "source": [ - "Data shapes" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "fedfab62", - "metadata": {}, - "outputs": [], - "source": [ - "omics.shape, metadata.shape" - ] - }, - { - "cell_type": "markdown", - "id": "ed9362eb", - "metadata": {}, - "source": [ - "See how common omics features are and remove feature below choosen frequency cutoff" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "4fca7328", + "id": "55b42bc2", "metadata": {}, - "outputs": [], "source": [ - "ax = omics.notna().sum().sort_values().plot(rot=90)" + "Metadata here is of type integer. All floats are proteomics measurements." ] }, { "cell_type": "code", "execution_count": null, - "id": "954c4682", + "id": "857b0522", "metadata": { "tags": [ "hide-input" @@ -216,64 +186,13 @@ }, "outputs": [], "source": [ - "M_before = omics.shape[1]\n", - "omics = omics.dropna(thresh=int(len(omics) * freq_cutoff), axis=1)\n", - "M_after = omics.shape[1]\n", - "msg = (\n", - " f\"Removed {M_before-M_after} features with more \"\n", - " f\"than {freq_cutoff*100}% missing values.\"\n", - " f\"\\nRemaining features: {M_after} (of {M_before})\"\n", - ")\n", - "print(msg)\n", - "# keep a map of all proteins in protein group, but only display first protein\n", - "# proteins are unique to protein groups\n", - "pg_map = {k: k.split(\";\")[0] for k in omics.columns}\n", - "omics = omics.rename(columns=pg_map)\n", - "# log2 transform raw intensity data:\n", - "omics = np.log2(omics + 1)\n", - "ax = (\n", - " omics.notna()\n", - " .sum()\n", - " .sort_values()\n", - " .plot(\n", - " rot=90,\n", - " ylabel=\"Number of samples\",\n", - " xlabel=\"Proteins (ranked by missing values)\",\n", - " )\n", - ")\n", - "omics" - ] - }, - { - "cell_type": "markdown", - "id": "b1ba957f", - "metadata": {}, - "source": [ - "### Sample metadata" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "e2ba978a", - "metadata": {}, - "outputs": [], - "source": [ - "metadata" - ] - }, - { - "cell_type": "markdown", - "id": "2877f00e", - "metadata": {}, - "source": [ - "Tabulate selected metadata and check for missing values" + "omics_and_meta.dtypes.value_counts()" ] }, { "cell_type": "code", "execution_count": null, - "id": "7f0d0364", + "id": "23657991", "metadata": { "tags": [ "hide-input" @@ -281,41 +200,24 @@ }, "outputs": [], "source": [ - "metadata[METACOL_LABEL].value_counts(dropna=False)" + "omics_and_meta[factor_and_covars]" ] }, { "cell_type": "code", "execution_count": null, - "id": "9688dd46", - "metadata": { - "tags": [ - "hide-input" - ] - }, + "id": "8bef0df5", + "metadata": {}, "outputs": [], "source": [ - "target_counts = metadata[METACOL_LABEL].value_counts()\n", - "\n", - "if target_counts.sum() < len(metadata):\n", - " print(\n", - " \"Target has missing values.\"\n", - " f\" Can only use {target_counts.sum()} of {len(metadata)} samples.\"\n", - " )\n", - " mask = metadata[METACOL_LABEL].notna()\n", - " metadata, omics = metadata.loc[mask], omics.loc[mask]\n", - "\n", - "if METACOL_LABEL is None:\n", - " METACOL_LABEL = METACOL_LABEL\n", - "y = metadata[METACOL_LABEL].astype(\"category\")" + "omics = omics_and_meta.drop(columns=[*factor_and_covars, *drop_cols])\n", + "y = omics_and_meta[group].astype(\"category\").rename(group_label)" ] }, { "cell_type": "markdown", "id": "713a7b35", - "metadata": { - "lines_to_next_cell": 2 - }, + "metadata": {}, "source": [ "## Before batch correction\n", "Explore data in PCA and UMAP space before batch correction" @@ -326,7 +228,6 @@ "execution_count": null, "id": "986f7cab", "metadata": { - "lines_to_next_cell": 2, "tags": [ "hide-input" ] @@ -335,14 +236,16 @@ "source": [ "omics_imp = median_impute(omics)\n", "omics_imp_scaled = standard_normalize(omics_imp)\n", - "PCs, fig = run_and_plot_pca(omics_imp, y, METACOL_LABEL, n_components=4)\n", - "ax = plot_umap(omics_imp, y, METACOL_LABEL)" + "PCs, fig = run_and_plot_pca(omics_imp, y, n_components=4)\n", + "ax = plot_umap(omics_imp, y)" ] }, { "cell_type": "markdown", "id": "2bf8ca74", - "metadata": {}, + "metadata": { + "lines_to_next_cell": 0 + }, "source": [ "## Combat batch correction\n", "Correct for batch effects in the data using a robust regression approach removing\n", @@ -355,15 +258,15 @@ { "cell_type": "code", "execution_count": null, - "id": "cc107f61", + "id": "1cf6f58b", "metadata": {}, "outputs": [], "source": [ "%%time\n", "X = median_impute(omics)\n", "X = acore.batch_correction.combat_batch_correction(\n", - " X.join(y),\n", - " batch_col=\"site\",\n", + " X.join(y.astype(\"category\")),\n", + " batch_col=y.name,\n", ")\n", "X" ] @@ -387,8 +290,8 @@ }, "outputs": [], "source": [ - "PCs, fig = run_and_plot_pca(standard_normalize(X), y, METACOL_LABEL, n_components=4)\n", - "ax = plot_umap(X, y, METACOL_LABEL)" + "PCs, fig = run_and_plot_pca(standard_normalize(X), y, n_components=4)\n", + "ax = plot_umap(X, y)" ] }, { @@ -413,6 +316,14 @@ "source": [ "omics - X" ] + }, + { + "cell_type": "markdown", + "id": "d27e6f10", + "metadata": {}, + "source": [ + "Done." + ] } ], "metadata": { diff --git a/docs/api_examples/batch_correction.py b/docs/api_examples/batch_correction.py index 8134052..158dc70 100644 --- a/docs/api_examples/batch_correction.py +++ b/docs/api_examples/batch_correction.py @@ -6,7 +6,7 @@ # extension: .py # format_name: percent # format_version: '1.3' -# jupytext_version: 1.18.1 +# jupytext_version: 1.19.1 # kernelspec: # display_name: Python 3 (ipykernel) # language: python @@ -29,8 +29,8 @@ # %% tags=["hide-input"] from typing import Optional +import dsp_pandas import matplotlib.pyplot as plt -import numpy as np import pandas as pd import sklearn import sklearn.impute @@ -41,11 +41,13 @@ import acore.decomposition -def plot_umap(X_scaled, y, meta_column, random_state=42) -> plt.Axes: +def plot_umap(X_scaled, y, meta_column=None, random_state=42) -> plt.Axes: """Fit and plot UMAP embedding with two components with colors defined by meta_column.""" embedding = acore.decomposition.umap.run_umap( X_scaled, y, random_state=random_state ) + if meta_column is None: + meta_column = y.name ax = embedding.plot.scatter("UMAP 1", "UMAP 2", c=meta_column, cmap="Paired") return ax @@ -83,123 +85,63 @@ def run_and_plot_pca( return PCs, fig +dsp_pandas.format.set_pandas_options( + max_columns=9, + max_colwidth=20, +) + # %% [markdown] # # ## Set some parameters # %% tags=["parameters"] -fname_metadata: str = ( - "https://raw.githubusercontent.com/RasmussenLab/" - "njab/HEAD/docs/tutorial/data/alzheimer/meta.csv" # clincial data -) -fname_omics: str = ( - "https://raw.githubusercontent.com/RasmussenLab/" - "njab/HEAD/docs/tutorial/data/alzheimer/proteome.csv" # omics data -) -METACOL: str = "_collection site" # target column in fname_metadata dataset (binary) -METACOL_LABEL: Optional[str] = "site" # optional: rename target variable -n_features_max: int = 5 -freq_cutoff: float = 0.5 # Omics cutoff for sample completeness -VAL_IDS: str = "" # -VAL_IDS_query: str = "" -weights: bool = True -FOLDER = "alzheimer" -model_name = "all" - -# %% [markdown] -# ## Setup - -# %% [markdown] -# ### Load proteomics (protein groups) data - -# %% -if METACOL_LABEL is None: - METACOL_LABEL = METACOL -metadata = ( - pd.read_csv(fname_metadata, usecols=["Sample ID", METACOL], index_col=0) - .convert_dtypes() - .rename(columns={METACOL: METACOL_LABEL}) +BASE = ( + "https://raw.githubusercontent.com/Multiomics-Analytics-Group/acore/" + "main/example_data/alzheimer_proteomics/" ) -omics = pd.read_csv(fname_omics, index_col=0) - -# %% [markdown] -# Data shapes - -# %% -omics.shape, metadata.shape +# data is already preprocessed: log2, filtered +fname: str = "alzheimer_example_omics_and_clinic.csv" # combined omics and meta data +covariates: list[str] = ["age", "male"] +group: str = "collection_site" +subject_col: str = "Sample ID" +drop_cols: list[str] = ["AD"] +factor_and_covars: list[str] = [group, *covariates] +group_label: Optional[str] = "site" # optional: rename target variable # %% [markdown] -# See how common omics features are and remove feature below choosen frequency cutoff - -# %% -ax = omics.notna().sum().sort_values().plot(rot=90) +# ## Data loading +# Use combined dataset for ANCOVA analysis. # %% tags=["hide-input"] -M_before = omics.shape[1] -omics = omics.dropna(thresh=int(len(omics) * freq_cutoff), axis=1) -M_after = omics.shape[1] -msg = ( - f"Removed {M_before-M_after} features with more " - f"than {freq_cutoff*100}% missing values." - f"\nRemaining features: {M_after} (of {M_before})" -) -print(msg) -# keep a map of all proteins in protein group, but only display first protein -# proteins are unique to protein groups -pg_map = {k: k.split(";")[0] for k in omics.columns} -omics = omics.rename(columns=pg_map) -# log2 transform raw intensity data: -omics = np.log2(omics + 1) -ax = ( - omics.notna() - .sum() - .sort_values() - .plot( - rot=90, - ylabel="Number of samples", - xlabel="Proteins (ranked by missing values)", - ) +omics_and_meta = ( + pd.read_csv(f"{BASE}/{fname}", index_col=subject_col) + .convert_dtypes() + .dropna(subset=factor_and_covars) ) -omics - -# %% [markdown] -# ### Sample metadata - -# %% -metadata +omics_and_meta # %% [markdown] -# Tabulate selected metadata and check for missing values +# Metadata here is of type integer. All floats are proteomics measurements. # %% tags=["hide-input"] -metadata[METACOL_LABEL].value_counts(dropna=False) +omics_and_meta.dtypes.value_counts() # %% tags=["hide-input"] -target_counts = metadata[METACOL_LABEL].value_counts() +omics_and_meta[factor_and_covars] -if target_counts.sum() < len(metadata): - print( - "Target has missing values." - f" Can only use {target_counts.sum()} of {len(metadata)} samples." - ) - mask = metadata[METACOL_LABEL].notna() - metadata, omics = metadata.loc[mask], omics.loc[mask] - -if METACOL_LABEL is None: - METACOL_LABEL = METACOL_LABEL -y = metadata[METACOL_LABEL].astype("category") +# %% +omics = omics_and_meta.drop(columns=[*factor_and_covars, *drop_cols]) +y = omics_and_meta[group].astype("category").rename(group_label) # %% [markdown] # ## Before batch correction # Explore data in PCA and UMAP space before batch correction - # %% tags=["hide-input"] omics_imp = median_impute(omics) omics_imp_scaled = standard_normalize(omics_imp) -PCs, fig = run_and_plot_pca(omics_imp, y, METACOL_LABEL, n_components=4) -ax = plot_umap(omics_imp, y, METACOL_LABEL) - +PCs, fig = run_and_plot_pca(omics_imp, y, n_components=4) +ax = plot_umap(omics_imp, y) # %% [markdown] # ## Combat batch correction @@ -208,13 +150,12 @@ def run_and_plot_pca( # Assumes normally distributed data. # # > ⚠️ Combat needs imputed data - # %% # %%time X = median_impute(omics) X = acore.batch_correction.combat_batch_correction( - X.join(y), - batch_col="site", + X.join(y.astype("category")), + batch_col=y.name, ) X @@ -222,8 +163,8 @@ def run_and_plot_pca( # Plot PCA and UMAP after batch correction on standard normalized data # %% tags=["hide-input"] -PCs, fig = run_and_plot_pca(standard_normalize(X), y, METACOL_LABEL, n_components=4) -ax = plot_umap(X, y, METACOL_LABEL) +PCs, fig = run_and_plot_pca(standard_normalize(X), y, n_components=4) +ax = plot_umap(X, y) # %% [markdown] # See change by substracting combat corrected data from original data. @@ -231,3 +172,6 @@ def run_and_plot_pca( # %% tags=["hide-input"] omics - X + +# %% [markdown] +# Done. diff --git a/docs/api_examples/diff_regulation_ancova.ipynb b/docs/api_examples/diff_regulation_ancova.ipynb index 40374ea..bca0a8b 100644 --- a/docs/api_examples/diff_regulation_ancova.ipynb +++ b/docs/api_examples/diff_regulation_ancova.ipynb @@ -72,14 +72,14 @@ "source": [ "BASE = (\n", " \"https://raw.githubusercontent.com/Multiomics-Analytics-Group/acore/\"\n", - " \"updt_diff_reg_api_example/example_data/alzheimer_proteomics/\"\n", + " \"main/example_data/alzheimer_proteomics/\"\n", ")\n", "# data is already preprocessed: log2, filtered\n", "fname: str = \"alzheimer_example_omics_and_clinic.csv\" # combined omics and meta data\n", "covariates: list[str] = [\"age\", \"male\"]\n", "group: str = \"AD\"\n", "subject_col: str = \"Sample ID\"\n", - "drop_cols: list[str] = []\n", + "drop_cols: list[str] = [\"collection_site\"]\n", "factor_and_covars: list[str] = [group, *covariates]" ] }, @@ -107,6 +107,7 @@ " pd.read_csv(f\"{BASE}/{fname}\", index_col=subject_col)\n", " .convert_dtypes()\n", " .dropna(subset=factor_and_covars)\n", + " .drop(columns=drop_cols)\n", ")\n", "omics_and_meta" ] @@ -357,7 +358,16 @@ "main_language": "python" }, "language_info": { - "name": "python" + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.11.10" } }, "nbformat": 4, diff --git a/docs/api_examples/diff_regulation_ancova.py b/docs/api_examples/diff_regulation_ancova.py index 6177cc6..19ece88 100644 --- a/docs/api_examples/diff_regulation_ancova.py +++ b/docs/api_examples/diff_regulation_ancova.py @@ -45,14 +45,14 @@ # %% tags=["parameters"] BASE = ( "https://raw.githubusercontent.com/Multiomics-Analytics-Group/acore/" - "updt_diff_reg_api_example/example_data/alzheimer_proteomics/" + "main/example_data/alzheimer_proteomics/" ) # data is already preprocessed: log2, filtered fname: str = "alzheimer_example_omics_and_clinic.csv" # combined omics and meta data covariates: list[str] = ["age", "male"] group: str = "AD" subject_col: str = "Sample ID" -drop_cols: list[str] = [] +drop_cols: list[str] = ["collection_site"] factor_and_covars: list[str] = [group, *covariates] # %% [markdown] @@ -64,6 +64,7 @@ pd.read_csv(f"{BASE}/{fname}", index_col=subject_col) .convert_dtypes() .dropna(subset=factor_and_covars) + .drop(columns=drop_cols) ) omics_and_meta diff --git a/docs/api_examples/diff_regulation_anova_ttest_two_groups.ipynb b/docs/api_examples/diff_regulation_anova_ttest_two_groups.ipynb index 623df48..a7312ee 100644 --- a/docs/api_examples/diff_regulation_anova_ttest_two_groups.ipynb +++ b/docs/api_examples/diff_regulation_anova_ttest_two_groups.ipynb @@ -67,14 +67,14 @@ "source": [ "BASE = (\n", " \"https://raw.githubusercontent.com/Multiomics-Analytics-Group/acore/\"\n", - " \"updt_diff_reg_api_example/example_data/alzheimer_proteomics/\"\n", + " \"main/example_data/alzheimer_proteomics/\"\n", ")\n", "# data is already preprocessed: log2, filtered\n", "fname: str = \"alzheimer_example_omics_and_clinic.csv\" # combined omics and meta data\n", "covariates: list[str] = [\"age\", \"male\"]\n", "group: str = \"AD\"\n", "subject_col: str = \"Sample ID\"\n", - "drop_cols: list[str] = []\n", + "drop_cols: list[str] = [\"collection_site\"]\n", "factor_and_covars: list[str] = [group, *covariates]" ] }, @@ -133,9 +133,8 @@ " pd.read_csv(f\"{BASE}/{fname}\", index_col=subject_col)\n", " .convert_dtypes()\n", " .dropna(subset=factor_and_covars)\n", + " .drop(columns=drop_cols)\n", ")\n", - "if drop_cols:\n", - " omics_and_meta.drop(columns=drop_cols, inplace=True)\n", "omics_and_meta" ] }, diff --git a/docs/api_examples/diff_regulation_anova_ttest_two_groups.py b/docs/api_examples/diff_regulation_anova_ttest_two_groups.py index bb34b84..dd0ab5c 100644 --- a/docs/api_examples/diff_regulation_anova_ttest_two_groups.py +++ b/docs/api_examples/diff_regulation_anova_ttest_two_groups.py @@ -46,14 +46,14 @@ # %% tags=["parameters"] BASE = ( "https://raw.githubusercontent.com/Multiomics-Analytics-Group/acore/" - "updt_diff_reg_api_example/example_data/alzheimer_proteomics/" + "main/example_data/alzheimer_proteomics/" ) # data is already preprocessed: log2, filtered fname: str = "alzheimer_example_omics_and_clinic.csv" # combined omics and meta data covariates: list[str] = ["age", "male"] group: str = "AD" subject_col: str = "Sample ID" -drop_cols: list[str] = [] +drop_cols: list[str] = ["collection_site"] factor_and_covars: list[str] = [group, *covariates] # %% [markdown] @@ -82,9 +82,8 @@ pd.read_csv(f"{BASE}/{fname}", index_col=subject_col) .convert_dtypes() .dropna(subset=factor_and_covars) + .drop(columns=drop_cols) ) -if drop_cols: - omics_and_meta.drop(columns=drop_cols, inplace=True) omics_and_meta # %% [markdown] diff --git a/docs/api_examples/normalization_analysis.ipynb b/docs/api_examples/normalization_analysis.ipynb index 04e8ceb..e4bdb33 100644 --- a/docs/api_examples/normalization_analysis.ipynb +++ b/docs/api_examples/normalization_analysis.ipynb @@ -65,11 +65,13 @@ "import acore.normalization\n", "\n", "\n", - "def plot_umap(X_scaled, y, meta_column, random_state=42) -> plt.Axes:\n", + "def plot_umap(X_scaled, y, meta_column=None, random_state=42) -> plt.Axes:\n", " \"\"\"Fit and plot UMAP embedding with two components with colors defined by meta_column.\"\"\"\n", " embedding = acore.decomposition.umap.run_umap(\n", " X_scaled, y, random_state=random_state\n", " )\n", + " if meta_column is None:\n", + " meta_column = y.name\n", " ax = embedding.plot.scatter(\"UMAP 1\", \"UMAP 2\", c=meta_column, cmap=\"Paired\")\n", " return ax\n", "\n", @@ -133,23 +135,18 @@ }, "outputs": [], "source": [ - "fname_metadata: str = (\n", - " \"https://raw.githubusercontent.com/RasmussenLab/\"\n", - " \"njab/HEAD/docs/tutorial/data/alzheimer/meta.csv\" # clincial data\n", + "BASE = (\n", + " \"https://raw.githubusercontent.com/Multiomics-Analytics-Group/acore/\"\n", + " \"main/example_data/alzheimer_proteomics/\"\n", ")\n", - "fname_omics: str = (\n", - " \"https://raw.githubusercontent.com/RasmussenLab/\"\n", - " \"njab/HEAD/docs/tutorial/data/alzheimer/proteome.csv\" # omics data\n", - ")\n", - "METACOL: str = \"_collection site\" # target column in fname_metadata dataset (binary)\n", - "METACOL_LABEL: Optional[str] = \"site\" # optional: rename target variable\n", - "n_features_max: int = 5\n", - "freq_cutoff: float = 0.5 # Omics cutoff for sample completeness\n", - "VAL_IDS: str = \"\" #\n", - "VAL_IDS_query: str = \"\"\n", - "weights: bool = True\n", - "FOLDER = \"alzheimer\"\n", - "model_name = \"all\"" + "# data is already preprocessed: log2, filtered\n", + "fname: str = \"alzheimer_example_omics_and_clinic.csv\" # combined omics and meta data\n", + "covariates: list[str] = [\"age\", \"male\"]\n", + "group: str = \"collection_site\"\n", + "subject_col: str = \"Sample ID\"\n", + "drop_cols: list[str] = [\"AD\"]\n", + "factor_and_covars: list[str] = [group, *covariates]\n", + "group_label: Optional[str] = \"site\" # optional: rename target variable" ] }, { @@ -157,101 +154,47 @@ "id": "500c7c2a", "metadata": {}, "source": [ - "## Setup" - ] - }, - { - "cell_type": "markdown", - "id": "27226512", - "metadata": {}, - "source": [ - "### Load proteomics (protein groups) data" + "## Data loading\n", + "Use combined dataset for ANCOVA analysis." ] }, { "cell_type": "code", - "execution_count": 4, - "id": "f58408a4", + "execution_count": null, + "id": "724b62d3", "metadata": { - "execution": { - "iopub.execute_input": "2024-10-15T08:04:40.861905Z", - "iopub.status.busy": "2024-10-15T08:04:40.861687Z", - "iopub.status.idle": "2024-10-15T08:04:41.753434Z", - "shell.execute_reply": "2024-10-15T08:04:41.753003Z" - } + "tags": [ + "hide-input" + ] }, "outputs": [], "source": [ - "if METACOL_LABEL is None:\n", - " METACOL_LABEL = METACOL\n", - "metadata = (\n", - " pd.read_csv(fname_metadata, usecols=[\"Sample ID\", METACOL], index_col=0)\n", + "omics_and_meta = (\n", + " pd.read_csv(f\"{BASE}/{fname}\", index_col=subject_col)\n", " .convert_dtypes()\n", - " .rename(columns={METACOL: METACOL_LABEL})\n", + " .dropna(subset=factor_and_covars)\n", ")\n", - "omics = pd.read_csv(fname_omics, index_col=0)" - ] - }, - { - "cell_type": "markdown", - "id": "abfe1216", - "metadata": {}, - "source": [ - "Data shapes" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "46a0da75", - "metadata": { - "execution": { - "iopub.execute_input": "2024-10-15T08:04:41.801341Z", - "iopub.status.busy": "2024-10-15T08:04:41.801189Z", - "iopub.status.idle": "2024-10-15T08:04:41.804608Z", - "shell.execute_reply": "2024-10-15T08:04:41.804364Z" - } - }, - "outputs": [], - "source": [ - "omics.shape, metadata.shape" + "omics_and_meta" ] }, { "cell_type": "markdown", - "id": "8b878346", + "id": "27226512", "metadata": {}, "source": [ - "See how common omics features are and remove feature below choosen frequency cutoff" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "3f889ca6", - "metadata": { - "execution": { - "iopub.execute_input": "2024-10-15T08:04:41.848755Z", - "iopub.status.busy": "2024-10-15T08:04:41.848552Z", - "iopub.status.idle": "2024-10-15T08:04:42.083439Z", - "shell.execute_reply": "2024-10-15T08:04:42.082957Z" - } - }, - "outputs": [], - "source": [ - "ax = omics.notna().sum().sort_values().plot(rot=90)" + "Metadata here is of type integer. All floats are proteomics measurements." ] }, { "cell_type": "code", - "execution_count": null, - "id": "1fd70efb", + "execution_count": 4, + "id": "f58408a4", "metadata": { "execution": { - "iopub.execute_input": "2024-10-15T08:04:42.105945Z", - "iopub.status.busy": "2024-10-15T08:04:42.105522Z", - "iopub.status.idle": "2024-10-15T08:04:42.261211Z", - "shell.execute_reply": "2024-10-15T08:04:42.260956Z" + "iopub.execute_input": "2024-10-15T08:04:40.861905Z", + "iopub.status.busy": "2024-10-15T08:04:40.861687Z", + "iopub.status.idle": "2024-10-15T08:04:41.753434Z", + "shell.execute_reply": "2024-10-15T08:04:41.753003Z" }, "tags": [ "hide-input" @@ -259,117 +202,32 @@ }, "outputs": [], "source": [ - "M_before = omics.shape[1]\n", - "omics = omics.dropna(thresh=int(len(omics) * freq_cutoff), axis=1)\n", - "M_after = omics.shape[1]\n", - "msg = (\n", - " f\"Removed {M_before-M_after} features with more \"\n", - " f\"than {freq_cutoff*100}% missing values.\"\n", - " f\"\\nRemaining features: {M_after} (of {M_before})\"\n", - ")\n", - "print(msg)\n", - "# keep a map of all proteins in protein group, but only display first protein\n", - "# proteins are unique to protein groups\n", - "pg_map = {k: k.split(\";\")[0] for k in omics.columns}\n", - "omics = omics.rename(columns=pg_map)\n", - "# log2 transform raw intensity data:\n", - "omics = np.log2(omics + 1)\n", - "ax = (\n", - " omics.notna()\n", - " .sum()\n", - " .sort_values()\n", - " .plot(\n", - " rot=90,\n", - " ylabel=\"Number of samples\",\n", - " xlabel=\"Proteins (ranked by missing values)\",\n", - " )\n", - ")\n", - "omics" - ] - }, - { - "cell_type": "markdown", - "id": "a1bec755", - "metadata": {}, - "source": [ - "### Sample metadata" + "omics_and_meta.dtypes.value_counts()" ] }, { "cell_type": "code", "execution_count": null, - "id": "cbec2c75", + "id": "12b9f9ae", "metadata": { - "execution": { - "iopub.execute_input": "2024-10-15T08:04:42.305874Z", - "iopub.status.busy": "2024-10-15T08:04:42.305743Z", - "iopub.status.idle": "2024-10-15T08:04:42.308958Z", - "shell.execute_reply": "2024-10-15T08:04:42.308750Z" - } - }, - "outputs": [], - "source": [ - "metadata" - ] - }, - { - "cell_type": "markdown", - "id": "a9849be5", - "metadata": {}, - "source": [ - "Tabulate selected metadata and check for missing values" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "feebf1a2", - "metadata": { - "execution": { - "iopub.execute_input": "2024-10-15T08:04:42.354573Z", - "iopub.status.busy": "2024-10-15T08:04:42.354448Z", - "iopub.status.idle": "2024-10-15T08:04:42.358121Z", - "shell.execute_reply": "2024-10-15T08:04:42.357913Z" - }, "tags": [ "hide-input" ] }, "outputs": [], "source": [ - "metadata[METACOL_LABEL].value_counts(dropna=False)" + "omics_and_meta[factor_and_covars]" ] }, { "cell_type": "code", "execution_count": null, - "id": "aa0c2670", - "metadata": { - "execution": { - "iopub.execute_input": "2024-10-15T08:04:42.386730Z", - "iopub.status.busy": "2024-10-15T08:04:42.386644Z", - "iopub.status.idle": "2024-10-15T08:04:42.389841Z", - "shell.execute_reply": "2024-10-15T08:04:42.389633Z" - }, - "tags": [ - "hide-input" - ] - }, + "id": "e414d8c8", + "metadata": {}, "outputs": [], "source": [ - "target_counts = metadata[METACOL_LABEL].value_counts()\n", - "\n", - "if target_counts.sum() < len(metadata):\n", - " print(\n", - " \"Target has missing values.\"\n", - " f\" Can only use {target_counts.sum()} of {len(metadata)} samples.\"\n", - " )\n", - " mask = metadata[METACOL_LABEL].notna()\n", - " metadata, omics = metadata.loc[mask], omics.loc[mask]\n", - "\n", - "if METACOL_LABEL is None:\n", - " METACOL_LABEL = METACOL_LABEL\n", - "y = metadata[METACOL_LABEL].astype(\"category\")" + "omics = omics_and_meta.drop(columns=[*factor_and_covars, *drop_cols])\n", + "y = omics_and_meta[group].astype(\"category\").rename(group_label)" ] }, { @@ -527,8 +385,8 @@ "source": [ "omics_imp = median_impute(X)\n", "omics_imp_scaled = standard_normalize(omics_imp)\n", - "PCs, fig = run_and_plot_pca(omics_imp_scaled, y, METACOL_LABEL, n_components=4)\n", - "ax = plot_umap(omics_imp_scaled, y, METACOL_LABEL)" + "PCs, fig = run_and_plot_pca(omics_imp_scaled, y, y.name, n_components=4)\n", + "ax = plot_umap(omics_imp_scaled, y)" ] }, { @@ -559,16 +417,6 @@ "omics - X" ] }, - { - "cell_type": "code", - "execution_count": null, - "id": "ff59ec5f", - "metadata": { - "lines_to_next_cell": 0 - }, - "outputs": [], - "source": [] - }, { "cell_type": "markdown", "id": "7f004ccd", @@ -616,8 +464,8 @@ "source": [ "omics_imp = median_impute(X)\n", "omics_imp_scaled = standard_normalize(omics_imp)\n", - "PCs, fig = run_and_plot_pca(omics_imp_scaled, y, METACOL_LABEL, n_components=4)\n", - "ax = plot_umap(omics_imp_scaled, y, METACOL_LABEL)" + "PCs, fig = run_and_plot_pca(omics_imp_scaled, y, n_components=4)\n", + "ax = plot_umap(omics_imp_scaled, y)" ] }, { @@ -695,8 +543,8 @@ "source": [ "omics_imp = median_impute(X)\n", "omics_imp_scaled = standard_normalize(omics_imp)\n", - "PCs, fig = run_and_plot_pca(omics_imp_scaled, y, METACOL_LABEL, n_components=4)\n", - "ax = plot_umap(omics_imp_scaled, y, METACOL_LABEL)" + "PCs, fig = run_and_plot_pca(omics_imp_scaled, y, n_components=4)\n", + "ax = plot_umap(omics_imp_scaled, y)" ] }, { @@ -774,8 +622,8 @@ "source": [ "omics_imp = median_impute(X)\n", "omics_imp_scaled = standard_normalize(omics_imp)\n", - "PCs, fig = run_and_plot_pca(omics_imp_scaled, y, METACOL_LABEL, n_components=4)\n", - "ax = plot_umap(omics_imp_scaled, y, METACOL_LABEL)" + "PCs, fig = run_and_plot_pca(omics_imp_scaled, y, n_components=4)\n", + "ax = plot_umap(omics_imp_scaled, y)" ] }, { @@ -842,8 +690,8 @@ "source": [ "omics_imp = median_impute(X)\n", "omics_imp_scaled = standard_normalize(omics_imp)\n", - "PCs, fig = run_and_plot_pca(omics_imp_scaled, y, METACOL_LABEL, n_components=4)\n", - "ax = plot_umap(omics_imp_scaled, y, METACOL_LABEL)" + "PCs, fig = run_and_plot_pca(omics_imp_scaled, y, n_components=4)\n", + "ax = plot_umap(omics_imp_scaled, y)" ] }, { @@ -881,7 +729,7 @@ ], "metadata": { "jupytext": { - "cell_metadata_filter": "tags,-all" + "cell_data_filter": "tags,-all" }, "kernelspec": { "display_name": "Python 3 (ipykernel)", diff --git a/docs/api_examples/normalization_analysis.py b/docs/api_examples/normalization_analysis.py index 7729b7c..354d7b4 100644 --- a/docs/api_examples/normalization_analysis.py +++ b/docs/api_examples/normalization_analysis.py @@ -1,12 +1,12 @@ # --- # jupyter: # jupytext: -# cell_metadata_filter: tags,-all +# cell_data_filter: tags,-all # text_representation: # extension: .py # format_name: percent # format_version: '1.3' -# jupytext_version: 1.18.1 +# jupytext_version: 1.19.1 # kernelspec: # display_name: Python 3 (ipykernel) # language: python @@ -40,11 +40,13 @@ import acore.normalization -def plot_umap(X_scaled, y, meta_column, random_state=42) -> plt.Axes: +def plot_umap(X_scaled, y, meta_column=None, random_state=42) -> plt.Axes: """Fit and plot UMAP embedding with two components with colors defined by meta_column.""" embedding = acore.decomposition.umap.run_umap( X_scaled, y, random_state=random_state ) + if meta_column is None: + meta_column = y.name ax = embedding.plot.scatter("UMAP 1", "UMAP 2", c=meta_column, cmap="Paired") return ax @@ -87,106 +89,43 @@ def run_and_plot_pca( # ## Set some parameters # %% tags=["parameters"] -fname_metadata: str = ( - "https://raw.githubusercontent.com/RasmussenLab/" - "njab/HEAD/docs/tutorial/data/alzheimer/meta.csv" # clincial data +BASE = ( + "https://raw.githubusercontent.com/Multiomics-Analytics-Group/acore/" + "main/example_data/alzheimer_proteomics/" ) -fname_omics: str = ( - "https://raw.githubusercontent.com/RasmussenLab/" - "njab/HEAD/docs/tutorial/data/alzheimer/proteome.csv" # omics data -) -METACOL: str = "_collection site" # target column in fname_metadata dataset (binary) -METACOL_LABEL: Optional[str] = "site" # optional: rename target variable -n_features_max: int = 5 -freq_cutoff: float = 0.5 # Omics cutoff for sample completeness -VAL_IDS: str = "" # -VAL_IDS_query: str = "" -weights: bool = True -FOLDER = "alzheimer" -model_name = "all" - -# %% [markdown] -# ## Setup - -# %% [markdown] -# ### Load proteomics (protein groups) data - -# %% -if METACOL_LABEL is None: - METACOL_LABEL = METACOL -metadata = ( - pd.read_csv(fname_metadata, usecols=["Sample ID", METACOL], index_col=0) - .convert_dtypes() - .rename(columns={METACOL: METACOL_LABEL}) -) -omics = pd.read_csv(fname_omics, index_col=0) +# data is already preprocessed: log2, filtered +fname: str = "alzheimer_example_omics_and_clinic.csv" # combined omics and meta data +covariates: list[str] = ["age", "male"] +group: str = "collection_site" +subject_col: str = "Sample ID" +drop_cols: list[str] = ["AD"] +factor_and_covars: list[str] = [group, *covariates] +group_label: Optional[str] = "site" # optional: rename target variable # %% [markdown] -# Data shapes - -# %% -omics.shape, metadata.shape - -# %% [markdown] -# See how common omics features are and remove feature below choosen frequency cutoff - -# %% -ax = omics.notna().sum().sort_values().plot(rot=90) +# ## Data loading +# Use combined dataset for ANCOVA analysis. # %% tags=["hide-input"] -M_before = omics.shape[1] -omics = omics.dropna(thresh=int(len(omics) * freq_cutoff), axis=1) -M_after = omics.shape[1] -msg = ( - f"Removed {M_before-M_after} features with more " - f"than {freq_cutoff*100}% missing values." - f"\nRemaining features: {M_after} (of {M_before})" -) -print(msg) -# keep a map of all proteins in protein group, but only display first protein -# proteins are unique to protein groups -pg_map = {k: k.split(";")[0] for k in omics.columns} -omics = omics.rename(columns=pg_map) -# log2 transform raw intensity data: -omics = np.log2(omics + 1) -ax = ( - omics.notna() - .sum() - .sort_values() - .plot( - rot=90, - ylabel="Number of samples", - xlabel="Proteins (ranked by missing values)", - ) +omics_and_meta = ( + pd.read_csv(f"{BASE}/{fname}", index_col=subject_col) + .convert_dtypes() + .dropna(subset=factor_and_covars) ) -omics +omics_and_meta # %% [markdown] -# ### Sample metadata - -# %% -metadata - -# %% [markdown] -# Tabulate selected metadata and check for missing values +# Metadata here is of type integer. All floats are proteomics measurements. # %% tags=["hide-input"] -metadata[METACOL_LABEL].value_counts(dropna=False) +omics_and_meta.dtypes.value_counts() # %% tags=["hide-input"] -target_counts = metadata[METACOL_LABEL].value_counts() - -if target_counts.sum() < len(metadata): - print( - "Target has missing values." - f" Can only use {target_counts.sum()} of {len(metadata)} samples." - ) - mask = metadata[METACOL_LABEL].notna() - metadata, omics = metadata.loc[mask], omics.loc[mask] +omics_and_meta[factor_and_covars] -if METACOL_LABEL is None: - METACOL_LABEL = METACOL_LABEL -y = metadata[METACOL_LABEL].astype("category") +# %% +omics = omics_and_meta.drop(columns=[*factor_and_covars, *drop_cols]) +y = omics_and_meta[group].astype("category").rename(group_label) # %% [markdown] # For simplicity we normalize here all samples together, but normally you would need to @@ -238,8 +177,8 @@ def run_and_plot_pca( # %% tags=["hide-input"] omics_imp = median_impute(X) omics_imp_scaled = standard_normalize(omics_imp) -PCs, fig = run_and_plot_pca(omics_imp_scaled, y, METACOL_LABEL, n_components=4) -ax = plot_umap(omics_imp_scaled, y, METACOL_LABEL) +PCs, fig = run_and_plot_pca(omics_imp_scaled, y, y.name, n_components=4) +ax = plot_umap(omics_imp_scaled, y) # %% [markdown] # See change by substracting median normalized data from original data. @@ -247,7 +186,6 @@ def run_and_plot_pca( # %% tags=["hide-input"] omics - X -# %% # %% [markdown] # ## Z-score normalization # Normalize a sample by it's mean and standard deviation. @@ -260,8 +198,8 @@ def run_and_plot_pca( # %% tags=["hide-input"] omics_imp = median_impute(X) omics_imp_scaled = standard_normalize(omics_imp) -PCs, fig = run_and_plot_pca(omics_imp_scaled, y, METACOL_LABEL, n_components=4) -ax = plot_umap(omics_imp_scaled, y, METACOL_LABEL) +PCs, fig = run_and_plot_pca(omics_imp_scaled, y, n_components=4) +ax = plot_umap(omics_imp_scaled, y) # %% [markdown] # See change by substracting z-score normalized data from original data. @@ -281,8 +219,8 @@ def run_and_plot_pca( # %% tags=["hide-input"] omics_imp = median_impute(X) omics_imp_scaled = standard_normalize(omics_imp) -PCs, fig = run_and_plot_pca(omics_imp_scaled, y, METACOL_LABEL, n_components=4) -ax = plot_umap(omics_imp_scaled, y, METACOL_LABEL) +PCs, fig = run_and_plot_pca(omics_imp_scaled, y, n_components=4) +ax = plot_umap(omics_imp_scaled, y) # %% [markdown] # See change by substracting median polish normalized data from original data. @@ -302,8 +240,8 @@ def run_and_plot_pca( # %% tags=["hide-input"] omics_imp = median_impute(X) omics_imp_scaled = standard_normalize(omics_imp) -PCs, fig = run_and_plot_pca(omics_imp_scaled, y, METACOL_LABEL, n_components=4) -ax = plot_umap(omics_imp_scaled, y, METACOL_LABEL) +PCs, fig = run_and_plot_pca(omics_imp_scaled, y, n_components=4) +ax = plot_umap(omics_imp_scaled, y) # %% omics - X @@ -320,8 +258,8 @@ def run_and_plot_pca( # %% tags=["hide-input"] omics_imp = median_impute(X) omics_imp_scaled = standard_normalize(omics_imp) -PCs, fig = run_and_plot_pca(omics_imp_scaled, y, METACOL_LABEL, n_components=4) -ax = plot_umap(omics_imp_scaled, y, METACOL_LABEL) +PCs, fig = run_and_plot_pca(omics_imp_scaled, y, n_components=4) +ax = plot_umap(omics_imp_scaled, y) # %% tags=["hide-input"] omics - X diff --git a/docs/example_data/alzheimer_proteomics.ipynb b/docs/example_data/alzheimer_proteomics.ipynb index a24d711..7b15cc6 100644 --- a/docs/example_data/alzheimer_proteomics.ipynb +++ b/docs/example_data/alzheimer_proteomics.ipynb @@ -46,13 +46,18 @@ " \"https://raw.githubusercontent.com/RasmussenLab/njab/\"\n", " \"HEAD/docs/tutorial/data/alzheimer/\"\n", ")\n", + "META: str = \"meta.csv\" # clincial data\n", "CLINIC_ML: str = \"clinic_ml.csv\" # clinical data\n", "OMICS: str = \"proteome.csv\" # omics data\n", "freq_cutoff: float = (\n", " 0.7 # at least x percent of samples must have a value for a feature (here: protein group)\n", ")\n", "#\n", - "covariates: list[str] = [\"age\", \"male\"]\n", + "covariates: list[str] = [\n", + " \"age\",\n", + " \"male\",\n", + " \"collection_site\",\n", + "] # clinical covariates to add to omics data\n", "group: str = \"AD\"\n", "subject_col: str = \"Sample ID\"\n", "factor_and_covars: list[str] = [group, *covariates]\n", @@ -92,9 +97,31 @@ "source": [ "clinic = pd.read_csv(f\"{BASE}/{CLINIC_ML}\", index_col=subject_col).convert_dtypes()\n", "omics = pd.read_csv(f\"{BASE}/{OMICS}\", index_col=subject_col)\n", + "meta = pd.read_csv(f\"{BASE}/{META}\", index_col=subject_col).convert_dtypes()\n", "clinic" ] }, + { + "cell_type": "markdown", + "id": "72a2ab90", + "metadata": {}, + "source": [ + "the variables for the collection site are based on the `_collection site` column\n", + "in the metadata, which is binary (AD vs non-AD). We will add it to the clinic\n", + "data here as `collection_site`" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "9a0f029f", + "metadata": {}, + "outputs": [], + "source": [ + "clinic[\"collection_site\"] = meta[\"_collection site\"].astype(\"category\")\n", + "meta" + ] + }, { "cell_type": "markdown", "id": "0e2ee221", @@ -274,7 +301,8 @@ "id": "0eba634b", "metadata": {}, "source": [ - "Check that the added clinical metadata is numeric" + "Check that the added clinical metadata is numeric\n", + "- `collection_site` is a string" ] }, { @@ -284,7 +312,7 @@ "metadata": {}, "outputs": [], "source": [ - "acore.types.check_numeric_dataframe(omics_and_clinic)" + "acore.types.check_numeric_dataframe(omics_and_clinic.drop(columns=\"collection_site\"))" ] }, { @@ -402,6 +430,14 @@ " \"../../example_data/alzheimer_proteomics/alzheimer_example_omics_and_clinic.csv\"\n", ")" ] + }, + { + "cell_type": "markdown", + "id": "fe8cb53b", + "metadata": {}, + "source": [ + "Done." + ] } ], "metadata": { diff --git a/docs/example_data/alzheimer_proteomics.py b/docs/example_data/alzheimer_proteomics.py index 7dcd810..6a5799c 100644 --- a/docs/example_data/alzheimer_proteomics.py +++ b/docs/example_data/alzheimer_proteomics.py @@ -22,13 +22,18 @@ "https://raw.githubusercontent.com/RasmussenLab/njab/" "HEAD/docs/tutorial/data/alzheimer/" ) +META: str = "meta.csv" # clincial data CLINIC_ML: str = "clinic_ml.csv" # clinical data OMICS: str = "proteome.csv" # omics data freq_cutoff: float = ( 0.7 # at least x percent of samples must have a value for a feature (here: protein group) ) # -covariates: list[str] = ["age", "male"] +covariates: list[str] = [ + "age", + "male", + "collection_site", +] # clinical covariates to add to omics data group: str = "AD" subject_col: str = "Sample ID" factor_and_covars: list[str] = [group, *covariates] @@ -52,8 +57,18 @@ # %% tags=["hide-input"] clinic = pd.read_csv(f"{BASE}/{CLINIC_ML}", index_col=subject_col).convert_dtypes() omics = pd.read_csv(f"{BASE}/{OMICS}", index_col=subject_col) +meta = pd.read_csv(f"{BASE}/{META}", index_col=subject_col).convert_dtypes() clinic +# %% [markdown] +# the variables for the collection site are based on the `_collection site` column +# in the metadata, which is binary (AD vs non-AD). We will add it to the clinic +# data here as `collection_site` + +# %% +clinic["collection_site"] = meta["_collection site"].astype("category") +meta + # %% [markdown] # ## Proteomics data: @@ -121,9 +136,10 @@ # %% [markdown] # Check that the added clinical metadata is numeric +# - `collection_site` is a string # %% -acore.types.check_numeric_dataframe(omics_and_clinic) +acore.types.check_numeric_dataframe(omics_and_clinic.drop(columns="collection_site")) # %% [markdown] # ## Checking missing data @@ -179,3 +195,6 @@ omics_and_clinic.to_csv( "../../example_data/alzheimer_proteomics/alzheimer_example_omics_and_clinic.csv" ) + +# %% [markdown] +# Done. diff --git a/example_data/alzheimer_proteomics/alzheimer_example_omics_and_clinic.csv b/example_data/alzheimer_proteomics/alzheimer_example_omics_and_clinic.csv index d5d567b..26ff0dc 100644 --- a/example_data/alzheimer_proteomics/alzheimer_example_omics_and_clinic.csv +++ b/example_data/alzheimer_proteomics/alzheimer_example_omics_and_clinic.csv @@ -1,198 +1,198 @@ -Sample ID,AD,age,male,Q6UX72,O14773,A0A0A0MQU6,P36222,P51693-2,P17174,Q9BWS9,A0A0B4J2D9,P00734,Q13433,P05154,P01258,P01593,P01834,D6RJG0,P48745,Q10472,P01023,D6R938,Q03591,P41222,Q99523,P26038,A0A1B0GV23,A0A087X1G7,A0A0B4J2B5,Q9Y6R7,Q9BT88,Q9H4D0,Q10469,Q9GZX3,Q6YHK3,P15086,Q13508,Q16658,O75874,O95206,A0A087X0D5,Q4KWH8,G3V164,O43916,Q02818,P02787,Q9Y653,A0A0G2JRQ6,P07093-2,Q9UHC6,Q99969,D6R934,E9PF59,P43234,P02794,P08294,Q8N436,P07996,A0A0A0MT66,P09382,A0A0C4DH67,P14174,O75752,F5GY87,Q96GW7,P04217-2,H3BMA1,Q9NX62,D6RGW2,P20933,Q5VUB5,P05362,P58401,Q53EL9,A0A087WW87,A0A286YFJ8,E9PMI0,G3XAK1,K4DIA0,P02452,H0YEX9,Q9BUJ0,A0A0G2JLB3,M0QZI8,O00391,P13591,Q8WXD2-2,P01042,O60279,P69905,Q8NI17,Q9BXJ3,O00468-6,A0A075B6K4,O15041,J3KNA1,A0A0C4DH33,P16870,G3V533,Q9Y5I4,P55283,A1L4H1,Q7Z4T9 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-Sample_002,1,75,1,15.630937410400385,17.662383485555512,16.070892837977333,21.2055321173656,18.96711787923628,20.065793452664952,,15.361978567131006,19.81444614760232,15.120966185408399,17.9517816515895,14.218837389313455,18.738423923264893,23.136196050937343,16.358521493160715,16.87016742876413,16.097021183924326,23.127447158092124,12.675842169188241,17.54913271306828,28.21654191571416,17.178894581355394,16.259960727638802,20.12937987432253,15.19721054273952,21.805747709185145,19.59785387959316,15.113257940595108,16.7583794888436,15.928621742569739,14.21505080074079,14.780673921390276,15.793696967118905,17.893481148414267,14.143217994132748,,16.478889818650856,15.985413929124324,16.268773273679017,17.735286617238845,13.73287821407787,17.128195440897834,26.039224994405995,15.228743841704635,18.583040289180865,12.542651693133308,18.055511162053207,18.02289452354151,20.79066726978238,15.697634469131133,16.14181527703861,15.751732006725124,20.833758524557698,14.424631355074206,16.684253479537343,14.76663899856905,17.66900678509752,17.627620935072365,19.592012815223296,16.497928319866528,,20.379597562707563,20.76040849817329,,19.203107493130517,15.629885409766338,16.431002727421376,14.726204020542793,14.639222560898657,16.092998385318857,18.027147713616884,,19.571323990927578,15.341903160627663,15.74833526659247,19.29663521509667,19.36692033137389,15.62186653422836,15.837769872962486,,15.072601555385043,18.49608600062964,20.9670445072558,21.653849545359577,22.33055804991101,18.48378269472498,21.023103055211234,26.75093716070154,17.228800492323543,17.596886179090603,15.386750707222408,13.903341280917594,17.57600022192672,13.67496030953983,19.61878113588641,17.005550025915053,17.4104359530986,17.751918908624052,15.824048097249024,19.32621084149431 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-Sample_004,1,63,0,15.968407525792422,18.57715737605843,16.001268845809427,21.06823016605402,18.421779264775324,20.485280978510303,16.054114404910848,,19.78628189348468,15.097208178892789,17.299060413687787,14.190440059489198,18.50884620103983,23.830663263502984,,17.316350454811214,16.188496335823036,23.43553127338529,,18.060336575886367,29.08811420746181,17.150559075410676,16.36103175373899,20.431125314536796,14.855356122350596,22.528535426807505,19.581977924441528,14.691266217690899,,15.765804875466642,14.164185430682664,15.760402406578045,15.623871445668541,18.338286041261625,14.782532871031764,,15.887622711891217,15.34556835266458,15.832912510526974,17.90476718055891,13.936681696341116,17.305444476060405,26.35831934650137,14.756733643434794,19.515671448649975,14.368525777553874,17.726634879502043,18.71912964612636,20.414244828497676,16.498993543981634,16.391797384560938,15.898417239440318,21.68931383631412,15.402980807242981,16.451412743960027,15.197132985817259,17.79489850217731,17.93104973700662,19.581535750197354,,16.096099521905884,21.269828523188735,20.910319840823767,17.209625300848657,19.241946356583277,15.300123221716099,16.965728808871635,13.75007610178174,14.19073754022064,16.607665561587375,18.53428780078458,,19.70232405188789,,12.648390060540905,19.658065007398513,19.23677625877255,15.337843179644391,15.536244606645258,14.324963626222788,15.841755033240487,18.398280251915516,20.77406846751506,21.25885784419322,22.379479772328562,18.47166777309534,23.00077010471726,26.98177813933775,16.94567342227389,17.106773937821742,16.41772248611935,14.933253734576482,15.440176089739513,,19.98657076935217,17.62426758626093,17.29667442002566,17.172337619425694,15.334466297942884,18.65058122053477 -Sample_005,1,74,0,15.534610656587256,16.828067995255036,15.051656367466682,20.646702513528194,18.31112188613723,20.19714258690029,14.957621774320137,15.97010922669452,20.637302905836606,14.56139307133557,17.97003864057042,14.204955849041081,19.17690814977551,23.3177216016888,16.017900063911988,17.690504679068642,15.867806973696483,23.676485374536,13.57002394599024,18.08067897439971,27.987254561298396,16.604592137944632,16.28075335719687,19.657026938610695,15.090145702498997,21.879818231074754,19.13033332077186,14.93801678010533,16.906434654889832,15.843332619638911,14.472064216735495,15.43634021433609,15.93009816485116,17.915880837304886,15.322794489657541,,16.79459642753757,,16.667837029109755,17.257956779496944,14.195821988158812,16.903972931191845,26.300324645678213,15.085672625818827,19.167350150364975,,16.97098652412372,17.89408945988235,20.654618766999736,15.491166347586303,16.440207272089808,15.359597298690852,20.794722440105883,13.78495648043658,17.537147053982284,15.5658229621094,17.57260956676169,17.772800733464422,19.341947803354113,16.039142457880565,,20.506614122002503,21.0140424413471,,19.432852035148677,15.146570850898637,15.694143924523244,14.251652443049558,14.496888389641763,15.87443959913735,17.71114831604123,14.33256901618144,18.385372683698872,15.691005988862232,15.971420324146441,18.956179471165374,18.885818863418695,15.493735635569513,15.78364933000623,13.909745341320498,15.06368028584005,18.387592061037164,21.062782515575172,21.22174183628188,22.716046587697154,18.007861709314117,21.147496548923158,25.729852038233027,17.24749441423014,17.62688607195616,16.45499754040497,12.974181128573226,17.632518689260127,14.544082551231195,19.427323587202952,18.104207131066122,17.39729129095711,17.89261739059633,15.537126550083345,19.5148027685966 -Sample_006,0,73,1,15.897085249634314,17.6823585612956,16.119190487870657,20.799505151538927,18.152182546179954,19.159404199574833,,14.219862157094859,20.148026383492898,15.278176192066702,18.457049914199672,14.457717403262963,19.243292547867636,23.503170633864745,15.570199445759544,17.913769253637675,15.9964936598085,23.102037845015296,,19.614640543972065,28.862470509592054,17.335147296644557,16.943574267404934,20.167229465834307,14.477763823909028,22.18883224060601,18.69030080233159,15.059740695697199,16.96511869863095,15.700488719134986,14.12605360030335,15.59010420780138,16.235310017222602,18.660408897795026,,,15.334560544200125,16.21295599456836,16.669500481542663,16.855980149864315,13.80162192912006,17.15564064918235,26.459304549132042,15.788922602118506,19.188393707803733,14.884702013198325,17.494128015754466,18.852792745900224,20.707245582856036,15.435587861881732,16.406155948086166,16.044873006340044,20.79667457527685,14.238755313543113,17.304360652898946,14.357310369732708,18.580490333417046,17.965174109794045,18.28254394814323,15.869179439928082,,21.16806761667701,21.26670234267945,,18.934027980057444,15.08761336879985,16.817748094438418,14.094676787210377,14.591765433542767,16.05623334903802,18.471105348042958,,18.47724244048161,,14.900971162415557,19.776626098192267,19.988039642859054,15.387750992609988,15.678063112472818,,15.775996104469579,18.39003181466345,21.06205684597377,21.093811804002982,23.150119135411888,18.151903477654592,16.900198594924557,27.18260940745244,16.885767299713603,17.411532064193086,,13.288613078289872,16.149137891319093,14.384186010624987,19.97029822949714,18.07893193266594,17.145327835264215,17.11462387823302,15.921784199414214,19.070568768343357 -Sample_007,0,77,1,14.781191098134567,17.45059937647008,15.818266977891623,20.39248618521574,17.19040720324578,18.96612686644539,15.14614709931581,20.471181277062414,20.410539727408523,14.935751904380393,18.70964012524788,14.296547140138996,19.63708362884412,24.761236766336093,,17.295099784536898,,23.589293624727883,,19.492649897362213,28.92598129973074,17.091305598058142,16.540937634600052,19.644963718064893,14.054148031712035,22.833198656816354,18.996048106449315,,,,13.08249878247719,15.164569086829362,16.45995210058809,18.146869903880535,13.619707179808982,,14.248298948150756,,17.397193480658988,16.286269808854833,13.101817018793781,17.22913800171528,27.00163068822122,,21.05778916524977,14.99952499171983,17.05918732298566,18.73418439781206,20.401979575421876,15.478204771400366,15.826209900850783,16.492923547169568,21.84552862239859,13.95896125102548,16.142801824086582,13.938816825030267,17.921846202216223,19.545884415569734,18.29140399489469,,15.651568758040447,20.890888043744507,22.225799646042834,,18.623019765726465,13.677843064047178,15.840992715998789,11.9560933959492,15.186321475413369,,17.885198580585552,,20.034806181567866,15.85724695251729,16.832635867802033,18.79625056910775,19.90349234688714,,15.269507392368466,13.799628858835254,15.793833474436095,17.63058175581643,20.574984612269017,20.573613444192894,23.749451693174862,18.099101202891543,23.70157425158656,27.420742186147113,16.607727184531683,16.88117073316491,17.04677581104756,,20.99368052158811,15.727884941331183,19.098284978229053,18.749154070705384,16.404841421140468,17.28851817579587,15.820042197764069,18.671761106741236 -Sample_008,1,70,0,14.750028142872816,17.51459367301609,16.00760528555872,21.268812529368216,18.692946827555392,20.392069484388866,,14.015051045317886,19.784719403945985,14.954968893657481,18.083209049905278,13.968059067328063,19.234794631603908,23.571578489823775,15.722693419729708,16.69118366962554,15.956532760115879,23.302525835111325,,18.625669719311002,28.39737591061318,17.393549406178042,16.849712235046486,20.10879529655156,14.151682103715654,22.338438120281996,19.993179495431917,15.220074937429844,16.637020814164813,14.959164723537794,12.044786811744848,14.301113641768847,15.842330871399177,18.227975316285434,15.126759604689642,14.767989822955515,16.595046065373793,,16.91141640167251,17.51965256814053,13.880688469395611,17.15096991616831,26.28151609084534,15.634110648168969,19.150063339140893,13.25232313170947,18.23545888511579,17.659919917040334,20.380588947423213,16.037749692697957,15.705876601003705,15.769501016183948,21.713901747272168,13.72092390247023,16.37349817426446,14.593328656450092,17.732283274834572,17.879742151370383,19.877012873919465,16.359957821777083,15.982974693186918,20.882300862417516,21.707545447205625,15.136615851510236,19.06217578461206,15.17441554295395,16.710818307431214,14.22801980943626,14.779538224715424,16.41635518735375,17.873406280236555,11.89176572132441,19.507650212901012,16.17955303013226,16.08963991447464,19.507017417042796,19.008464527593908,15.878533123390314,15.952721787851745,,15.992446215109013,17.804791972606083,21.199186012932792,21.1394326916873,22.760845097033897,18.276814762621683,,27.507095117361146,17.14227630022002,17.76268677760266,16.032123267175653,14.226847551563134,15.853199030098615,13.077852643966422,19.242731024393013,18.725702939710832,17.323089816988155,17.858254718095843,15.236187955215623,19.26651420168266 -Sample_009,1,79,0,15.721043579368287,18.079780169551608,15.97857535930074,20.709368779998993,18.19852177850942,19.677125819377206,15.101651617365905,,20.878211948221868,14.318329172309042,18.15725378823889,12.509245731027232,19.213917035350306,23.249605667027087,,16.804896424850625,16.37053642827599,23.001990357488815,13.72299040328391,18.348626455089466,28.711189499436937,17.40236609811726,15.964145000172191,19.730961482946537,14.770063763468254,23.01903175003213,18.55034237961012,14.734185845253263,15.810825775900966,15.784547286961992,13.954902531278995,16.2604485377343,15.760372658918438,18.564252197912925,13.79870662859605,,15.792544572795661,15.619519018544368,16.234190605599203,17.75475235568844,14.563526222926601,16.974942036311077,26.63679608829153,15.435511816602942,19.11010475457657,13.851834711545969,17.65625878198572,18.374030821246677,20.470885975092173,16.119314941779187,16.73476604881008,15.636163806299235,20.95068750652526,14.80057893688115,16.52426586632307,15.285179241559383,17.722735105320282,19.147017465627112,19.402332525505127,15.562425278418473,15.787055627025131,20.612293944151403,21.631053129182487,,19.008974973274757,15.321825039202277,16.44124553830171,14.294462297065555,14.080098434902716,15.881916598335083,17.772045499919315,,19.39909443479575,15.151961989005937,15.82748885766379,19.629244323198602,19.030898788472566,15.683368501662173,15.290484929238888,14.066136502879296,14.805232077847089,18.235707207572464,20.897905450383018,21.34770570438881,22.955373921892683,18.209387174030837,16.030546749945408,26.640493094033168,16.698141470341028,16.812452512722427,16.14909772190751,14.58541004480942,17.753855339036082,16.48379831371352,19.885343085720656,16.87884010487836,17.457538568025665,17.318267654320426,15.588037023858975,18.880914492241175 -Sample_010,1,73,0,15.644911364525697,17.850284238772392,16.112625309408894,20.489737979202395,18.580134905438392,20.407777719431806,14.762175396014536,15.279502615630054,19.22532513321817,15.072683324084378,18.0156154808368,15.052927025591627,18.346968410057684,24.03382095913627,15.755111495361561,17.613080353817818,16.192590063943047,23.174142114364717,13.230145950945545,17.79268615320536,29.265023506090998,16.983235444957657,16.37709082342841,20.36093975670298,13.921964844366826,22.371516908205137,19.727249812990635,15.290211683190968,16.0855431284695,15.728432287966937,13.810387079807274,15.79077950964383,16.46990955943554,18.522958724191337,14.331067001543868,,16.572318121908562,15.878493272739943,15.793949237598733,17.873757528401427,13.62929991680647,17.35989403317409,26.631220041617503,15.077696531471766,20.59623696838695,13.152132246634638,17.90803522483645,18.721617306284625,20.89546480480157,16.266031012963285,15.641579710835046,15.77944153904429,21.32655772368863,14.008307391582774,16.829255386692957,14.05478331500221,17.57512557083431,17.658269022572036,19.55298059843212,15.431764741682956,16.265138855101796,21.102349956795535,20.806737126393127,15.52702305705338,19.178630965723038,15.347097402925694,16.926241875615887,13.920708212640962,14.491415444940937,15.514164914248207,18.129004987572,,20.992930818192153,,15.357117435493462,19.488641260028512,19.306788621735887,15.971414359732274,15.76986810280257,14.522015616762586,15.798449848957036,18.577475851468133,21.038307496052717,21.48082741915375,22.40607781629752,18.042301293092486,18.10957945618527,27.566216903354928,16.876828103539154,17.561712715058565,16.598872486303907,13.670394220834593,17.82028250138736,14.286712290415041,19.64945497319449,18.348717755046316,17.72630589989779,17.421005276981905,15.799454756548428,18.711642294817132 -Sample_011,1,63,0,15.592176419838083,18.346086379376917,16.2404108256629,21.16042357680611,18.59000663739182,20.393412716558412,15.122082295120796,17.67931461082453,20.26883151446378,15.33748865633442,17.89015691815766,14.768292067095514,17.032922479342968,23.138048793314745,,16.410407614427175,16.32331044809336,22.91796111806169,12.84128446366588,17.310125830958768,28.99575145708077,17.369246680567983,16.901888843161537,19.916388386164286,14.545971822889737,22.287566552905517,19.21585022989702,15.257359641758564,16.10415017057334,15.694290821354887,14.27260586681578,15.242576945064974,16.105493583057832,18.646392807631496,14.8771961225344,14.916102142906288,16.83614832990871,16.185901984641646,16.19828241134641,17.9427299737221,14.779111356225345,17.253657082980965,26.390358849457282,16.097534196413378,18.370362284516155,14.869837421440977,18.501274251070974,18.71051092492875,20.296047433509408,16.403122185815505,16.551664732051947,16.40392168296564,21.198737729452557,14.31171880134356,15.77990547101938,,18.143376829785055,17.250480300262605,19.373643799014722,15.977895653770027,16.48504667086088,21.153320549555325,21.282528394738925,16.03859535881044,19.369454906933683,15.157769260523406,17.09258263286265,14.68733926479105,14.48922347900583,16.068507364182356,18.010600323787298,,18.001843679336986,16.078865660961036,15.048552726741356,19.055931613153298,19.374072092182754,15.920380207674151,15.647144380262473,14.538605993650389,15.280033721945893,18.243547370218472,21.45245290915274,21.498095277239912,22.57207497484705,18.4504947943419,19.778804854895053,26.78450696279425,17.04384366987911,17.696202410860963,,13.548191747658176,17.842085770121322,16.581065159214,20.097167019569916,16.789097979983183,17.245963039867743,17.707249796345003,15.884566759306814,19.182875469382004 -Sample_012,1,77,1,15.51085095301051,16.92510254902132,15.695294464089173,20.95274728930095,17.766379480121977,19.464436066754583,,15.666188455191758,19.962484787572542,15.149947865003796,18.915204496393066,14.283087787661982,17.565323971815182,23.66759473535996,,18.050079634089833,15.633901081898609,22.853390563837152,12.375850397880571,18.645355539381363,28.205734201491577,17.010537496125334,17.05006501588513,19.48132989217928,14.622357186419991,22.3114754638299,20.986807094160692,14.560196604764958,15.26674937409525,15.173879000925105,13.762645723719332,15.262604012385165,15.953168309045774,17.94963233535922,14.399751473121539,,16.673456275933145,15.220859930197829,17.92822874469849,17.15183350858457,14.308150685449819,16.97523118803316,26.07810423389013,15.628949085245829,19.67350857428056,13.790271228927747,17.43496144977563,18.012107026345905,20.62028561359951,15.735856671112382,16.508115376756166,15.259244868963954,20.736989499556618,13.19651418127993,17.406751531443586,,18.437837902876737,17.90398055968244,19.655028727120033,15.332597423513535,14.712838885448214,20.39554720965952,22.045343234707868,15.7637315857713,18.916012275779696,14.57132480113627,15.97310787648074,14.487763504783342,14.675880816964025,16.076335616826743,18.52465947572922,,19.40998207922468,,16.38247653495937,19.143753138192466,18.00566600645497,15.370940775793503,16.381059689250943,,13.863935090143649,17.91793535834276,21.242029103408438,20.567622958908157,23.273693030560963,18.14449596959423,19.403972896011936,26.640576056634057,16.255510846773326,17.169142994626384,16.2667742472333,12.392503086577225,18.455273282401112,,18.67155899075684,18.615595514505117,16.76017435935848,17.46113692842897,15.914065999716009,19.27700241682726 -Sample_013,0,63,1,14.86347415863906,17.47665066869829,16.575965264521848,20.491754520150202,18.07100990435743,19.029668720611337,,18.652929197177322,20.346272677361544,15.33689849825602,18.458643660416396,13.708708293296187,18.896624536220436,24.193906030222575,,16.87892857675219,16.116002806485994,22.80182704345302,,19.042112889952136,28.57846771533852,17.5951746036641,16.706730917975023,20.026198201343966,,22.480593373082975,19.836895205543716,14.916228366688467,16.13326499819373,15.042292441368106,12.487594734092111,13.680847848950728,15.62901425407303,17.30958848271403,13.058601536623005,14.662245801173638,15.73541223642595,,17.537074992749275,17.88588615407422,,17.26002104868609,26.6069222814554,12.692244185873538,20.666705651620173,13.62928612979148,17.871057140757582,18.34430688089639,20.448232404908175,15.81088273581405,15.823241469308446,16.227018014141443,21.2618174594274,13.201237169778492,15.643529468296885,,18.01829765601631,18.75420532140769,18.48563795727801,15.423671198254857,15.825363523692017,21.252427664041644,22.20408093723867,,19.1776038488443,16.02639207147401,17.109276876556628,14.648917185804141,15.184561215201208,,18.46091003674133,11.253384418170928,18.865236565820535,,16.429291543708572,18.441766797105032,19.967268130591805,15.181515504853953,15.887488661213359,13.946466734854882,16.01379597191151,17.523494716751156,21.04523423404993,20.83585245832297,23.455813323065875,17.91552529183048,,27.371290240584916,17.185474205210976,17.045825472126307,16.64770489385233,11.393091104458776,19.035375528624083,15.590425663611551,20.093330191722057,17.7670313721661,16.78013322494832,17.388608579123183,15.621910566769834,19.363646327458007 -Sample_014,1,62,1,14.887739368606741,17.47640333527675,16.085208391230925,20.354243731338418,18.066432006122987,19.793019298847913,15.448616185290144,,20.48117527530082,14.930941762521329,18.347069279677676,14.885432649292413,18.408424077823327,24.418103720443167,15.49876011415292,16.844672342343546,16.562484788384527,23.406220578826424,,18.838080936897388,29.461326187723266,17.14436760055598,16.634865986658006,19.981501957636848,,22.856751875080725,18.966154773020115,13.680516737064162,16.104236730434224,,,16.666199726480453,17.029044022672675,18.347233143971412,15.382604634531127,14.495905273530584,15.337403993353107,,16.954101594767636,17.33175780547087,,17.43236922046851,27.19400714870335,,19.202661323354086,,18.070256911552868,18.517055754945172,20.479114147202456,16.476881524404703,15.778171800723698,16.824877867354797,21.289296783101918,,16.004411482689854,,18.307578694711808,17.814638593229002,19.23042069736195,,16.44602138029948,20.96690452709649,21.775106475337754,,18.567642337698143,14.112733948317516,16.823644305204958,13.637466208498248,14.129895656119444,,18.39334737853529,,20.526801520086085,16.382566245430795,13.967123509545852,18.524534541485043,19.660381585412686,15.104741746068738,15.851406119373918,14.215250662526872,,17.526992740964634,21.103058366562653,21.159002839643385,22.98656399928674,17.708084035370334,21.220816839005398,27.39998506914548,17.321391409204928,17.566781180869192,,,21.309425698707866,,19.75137110520331,20.009763535396438,17.060224908334323,17.39567363103451,15.505050469782226,19.092176440875964 -Sample_015,1,73,1,14.51030492873849,17.36405982626074,16.45067815415,21.228458059721056,17.379927747541494,19.743745772132854,,,20.25575372535746,15.14124588622727,17.788828434718162,,19.279929754398967,24.026942044609527,,16.569615522298623,17.120562371026885,23.14679596200297,,19.818276048644123,28.68201750859987,17.037168376207962,16.1866467046651,19.124047141633927,,22.364259717250018,19.874251308900114,15.767199124289682,16.720873921123278,,,,16.065831902006433,17.294122197884136,,15.063492185532985,16.282353336679236,,18.169847339630586,17.728403638399815,,17.622580723668033,26.894588739391576,14.315409142528763,21.001911008864802,14.179472695732276,18.950384137074845,17.863334630958505,20.231566034244057,16.009916071982197,15.574100334390351,17.07529519315042,21.205894647154224,,,,17.883455837738552,17.988306589572336,18.7387419064788,17.251957208889884,14.621032456098566,21.13933744379212,22.552194624021904,,19.211956004817864,13.217952818227198,16.883267135591304,13.660486914780229,16.18483570243119,,17.548873753063518,,19.81665860273836,16.4072436429064,16.170949195788303,18.26725532943263,19.738745616728238,14.697148293125545,,13.56738145646354,13.92420296459773,17.93674692555647,21.799435783860595,21.278414150664133,23.03149391026676,18.04197474542066,20.593002944134682,27.345713990352266,17.374493625090853,17.23531688389123,15.889507305510104,,,14.843081648581531,20.401355324350906,17.95348130676635,16.448486253347358,18.057322976682062,,19.380752350810194 -Sample_016,1,70,0,15.533096801181925,16.98785806659497,16.023566727026253,20.74422491769051,17.944904688297644,19.914208372351265,14.704876919236362,15.216106391947667,20.465308070064637,15.376951373482525,18.316862095250478,15.049179341515991,19.57173100561865,23.82077915136646,,17.823697263199236,15.861936056538324,23.232861794160563,,18.12593965559228,29.090657130087944,16.921127877551058,16.779317791970293,19.14223687431603,,22.803934804492012,19.698858092799313,14.188446682884138,,15.085708118056509,12.580068181039934,,16.83507390384946,18.424002730304622,14.919790247095692,14.82037015792585,16.049408040477502,,17.242869827056218,17.414525502078103,13.585268482734348,17.184886084987404,26.790926345268012,14.766547105867685,21.07296604453011,14.17581753613215,18.523091933167528,18.727018126684506,20.637456700522375,16.16245909733398,16.05670716536499,16.815304522936618,20.96301978893408,,15.68325165600942,,18.15040273309554,18.670646633251504,19.06689082782602,16.172704619106423,16.48803599833691,20.850223280365114,22.457545706831777,,19.24231642635519,14.556601239932133,16.39395232952304,13.257783029423642,14.564293721012826,16.485815185427082,18.131950349377114,,19.482117995915974,15.977069030057654,14.746544868457596,19.075515872656176,20.075278542883314,15.049309484977897,,13.430819018590952,15.063471777725761,17.75288295820584,21.202004667927824,21.09153917624801,23.223762521416717,18.006359125570118,22.229713786548565,27.314244406632454,16.93095971372682,17.497932825899078,16.895695642465032,,18.539656757333553,15.286971540165373,19.54206418793685,18.674760472801967,16.71980877123429,17.357691194788416,15.848827114528378,18.937010328142872 -Sample_017,0,79,1,15.617415785935687,16.95244595243227,16.10081277870217,21.0891139007755,17.874139092368665,19.172851087714733,,17.277915356836964,20.418054358110382,14.882906164652953,17.969871379810364,15.207127848704328,20.817078801644897,24.869886875593078,,17.280871562820998,15.757864747230395,23.41883044482242,,18.913557815627282,29.070178775563758,17.252440369112747,16.652770917294642,19.207779794304336,13.754531364946393,22.997119684931942,20.40940621620948,15.036474310405286,15.147123234813495,15.178911748887296,13.991597962440185,14.848592187663666,15.257563942179095,18.04553438264342,14.706636604300762,14.876303537635822,15.807335266763614,,17.1153224776537,16.866858861230927,,17.15276496456606,27.195446413991252,15.946801443127256,19.765169024429557,,17.834838558540042,18.41658004663835,20.942077474581172,16.041617212062864,16.01711253872958,15.905953513306336,21.256752900414178,13.966598476651619,16.901128923146924,14.486090871321194,18.338540676151812,19.5909556693794,16.488408355668664,15.735168116088717,15.979765687270934,20.99032672523951,21.87820717636516,,18.928816620407478,14.446923507084536,16.19561551190025,12.860810973575388,15.655575377818494,13.697602020076546,17.68439100599109,,22.169055347973057,16.1605557567608,15.55607892997917,19.331834328490128,18.595067356386842,15.911841702916986,14.901369905507098,14.142981109659921,15.546370625203995,18.015393953035225,21.065969916842565,21.01281325259133,23.156211950502442,17.800532232831948,17.525134127212,26.866786350752047,,16.934944130373335,,11.993241701242411,18.310553568578154,16.55557515331072,19.47472415435448,19.89900927078549,17.15396974985392,17.12338354325993,15.48961206611202,18.914496725153843 -Sample_018,1,71,0,15.365112283333538,17.25392536947524,15.552638260306098,21.54045325588246,18.83930971951259,20.70536092005984,,14.091559836492701,19.385041899067495,14.799329156666289,17.74600096791631,12.893678424194118,18.600987145725597,22.560598258068858,15.99010093344222,17.387525670042823,16.555655189040223,23.274867368084312,13.511376621477757,17.13750152249588,26.326420314685098,17.212663505833465,16.565851776026264,19.58234564859053,16.547216978676165,21.185489479830956,18.863459223394056,15.405133800502547,16.56392776481959,15.830258707327493,14.319072008701244,15.875606694139947,16.994298099199387,18.767998508435216,14.489290496924484,,17.19564885043117,,16.179096628739988,18.019405274737043,14.484934725456935,17.022633139337927,26.33712344366306,15.172093867839934,18.42546486966756,13.492088379983947,18.20902239640887,18.099324211117683,20.57638988772423,15.763984694243097,16.128366795610752,15.689087710369886,20.70968934054601,13.417208951078827,16.409510194095173,15.485164013743027,17.753191954767182,17.7371721305453,20.300973770287467,16.63889710766239,17.171172062676725,20.95119069750062,21.09379182061296,16.749376295833013,19.648621997444042,15.442233440017391,16.436160615987227,14.14358609241708,14.848417400178535,16.031226506098974,18.038037164242823,14.34566011703321,19.15800881611705,16.29830258362425,15.221038626852053,19.821751895048333,19.04581014432255,15.760720048970077,15.726070111019563,,14.246239430729855,18.50567201554162,21.709431362210218,21.816693558894315,22.36148161108503,18.75760771443129,13.686186529502743,26.372859896992214,17.16008376180617,18.131270435128453,16.0552519800264,13.296271818714937,17.38195359658914,15.496306208315538,19.64788754897915,16.70340566993694,17.74317399851627,18.126873169653443,16.069065535354472,19.313069298890643 -Sample_019,1,72,0,15.130377001374454,17.59172047124659,16.357223102743795,20.886581121078894,18.271304149486905,19.821951054322646,,18.65049499659022,20.3300006225758,15.09605463013268,18.397148425620664,14.127628047036005,18.787305075348964,24.35076663444056,,17.083275934079225,16.065861642033543,23.040500435831955,,19.103400034296367,27.27410654145415,17.603004845335654,16.381617406663768,19.807711815617232,13.348459777248834,22.851873971351676,19.68484801335732,14.485758936578115,16.231630044287044,14.710522065404218,12.499255164436143,13.763240941379593,16.400384497265808,17.91199316106647,,15.070026906738065,15.942660003714135,16.3025705975339,17.37218874987877,17.80588809824043,,17.186347774555102,26.33820239436772,15.181581319545527,19.429984890441478,13.460824068454938,18.07587995269222,18.615138487551686,20.21135793598821,15.55441706371491,16.300923653353063,16.355687145517315,20.89015868124587,12.370281790801121,15.434465723709314,,17.777760176531782,17.987565189861968,19.21008017592862,15.368189241712027,14.755406974586789,20.99106523658691,22.399457609655766,14.842222763365578,19.29525886713267,15.640118696295666,17.132223574903612,14.002725756196819,15.505357762518194,,17.59483256859328,,19.676471277894123,,15.489502801879212,19.88416353059014,19.846997016079676,15.13006335158841,16.086054081116696,14.639531049728172,16.36410712917012,17.730726039248207,21.065097079366453,20.730011597242825,22.670590233280905,17.964450954524523,18.23245869595891,27.08176461208818,16.99950125010307,17.16250826981874,17.37683190991309,15.114251015805351,16.28259060735009,15.254533445050194,20.428091125816383,18.06958366727391,16.49702707407522,17.494484521452133,15.837262000913618,19.29257566419497 -Sample_020,1,66,1,15.195591033119031,17.74808984190296,16.058473219636824,21.185849974404267,18.083992471602784,19.944183007891983,,14.369960436427036,20.330919065817735,14.751423821047442,18.35727452377762,,19.412644526982,23.744112179794964,15.612941593557006,18.147493288278,15.627851337779338,23.136220619598827,13.852052818645825,18.32903778380873,28.390950746119174,17.47413902471364,16.958930993096597,19.91280767284528,14.703138959532065,22.691402225297473,19.49449306674043,14.660480930363121,16.883038776717363,15.025819843135924,14.305259928635206,15.099042434725932,15.600462060857962,17.45111097710972,,,15.35856911214206,15.80374890593086,17.7182700977594,16.94093195658187,13.447880926289505,17.66678397884636,26.301649428565007,15.107046862912501,19.56605845253697,13.039387647626821,17.49776487533482,17.989344082753036,19.911203795474826,15.881769789528501,15.913008260542606,16.159086324313485,21.497732111125494,14.021444293466,17.09379987846482,15.376742901798744,18.057891273650156,18.494367812162956,19.943116716010344,16.139868877929835,15.766996909826789,21.444849338235162,21.271185014818432,,19.04954447804174,14.679631181289455,16.36745954467618,14.256722815752736,14.065494695945885,15.481242052113087,17.84164822558918,,20.706806259106,16.207009254392013,15.25759429702641,19.703175298425116,19.400991845462265,15.68501543592038,15.425477547360748,,15.492920369756396,18.02556169184525,20.728093750747412,20.660055429086697,22.75735928385701,18.256742104555208,22.901430305933992,26.208689541901798,16.707098313685286,17.486438688419454,16.511309294476852,13.439978459092016,19.747502885414256,14.911587012631019,19.21104283653106,18.689731329530648,16.896388857870054,17.91522155013445,16.12143059826277,19.042867690517266 -Sample_022,1,74,0,16.778923433930448,18.013748614979278,15.673182568297536,21.338768068468916,18.194381895260722,20.117983234614844,14.056890365701323,14.467505178682492,20.350190316454842,13.9888784643505,18.396455314902337,14.574191593572602,18.38064350534129,23.015079127673847,15.673742114484973,,16.095584389338978,23.33666890442628,14.367656166046745,17.56954680306348,29.098468759904318,16.85379839266526,17.226788325797777,20.058102241740563,16.70325114235188,22.033461987245808,18.995458881913002,,16.46369723032677,15.728803850375927,14.106019572002898,16.55900264721874,14.420464767538268,18.288322014801324,14.052939625393387,,15.704783750486206,15.489423298374186,15.70998585873345,17.666213056833236,14.155634473384733,17.181883816205538,26.694386809078537,14.948330600903871,18.56721315839391,14.15259277022138,18.098438557530613,18.613562087905752,20.80100256142666,16.19874627091412,15.668320412386068,15.621960967851756,21.258623250611098,13.76962853363753,16.773175535287805,15.071230421792109,17.840875385890698,17.094074785408953,19.087372193428962,16.59120421738029,16.462637438046947,20.813833436307267,21.484538730296514,,19.332018103804913,15.449340111608503,16.378439600413575,13.756275944075337,13.761251124001129,14.201062436608138,18.0193022723562,,19.299444210398292,15.839706652820398,15.88831647142484,19.029947362899968,18.661015077813232,15.781974467409345,15.85401154085482,,15.521930698461588,19.527311147457784,20.970335272197815,21.536897787403,22.851803264814492,18.571850530628353,17.906269765195205,27.157339542800674,16.869511292148072,17.343640629050697,,14.124627618802355,20.330786977295546,14.460608000537668,19.807814779506597,18.016462655451022,17.544667112990325,17.51417876270348,15.58098755558163,18.703930390940954 -Sample_023,1,80,1,14.913207541828575,17.23041541990873,16.183308563817107,21.1397878640442,17.878290728359204,19.827308683639103,,15.639407065904155,19.255423538786378,15.557708388763722,18.441211591692593,14.657625274041786,19.396366855972715,23.980519821011946,,17.02980349990138,16.54345350250216,22.999590537198664,,19.91922168986532,27.509141334888238,17.514334217544786,17.095475417083247,19.847600871703055,16.58871017564086,22.384582994168433,20.208557215785792,15.350946328421859,16.984837898312154,15.402628406047008,11.330016356607645,13.841791593611767,15.880077750444606,18.012132778474466,15.278524040820258,15.676993084640001,16.00332815007306,15.942774620329605,16.89573270986948,17.67885831788418,14.244708174466194,17.434034496922983,25.568688319029526,14.6248896979677,19.519426056924708,14.524843211032797,18.100867946685337,18.580804049498912,20.75949345542596,15.654279175448476,15.791839641092242,16.234915640287042,20.88561846200403,12.820977666143492,16.808896340452712,15.502738102125859,18.417967857329167,18.145876498265455,19.851393822989856,16.682794356875362,15.958977529882558,20.954679733641935,21.58581711597506,,19.45131601940053,15.0330761167807,17.081387862414857,14.316182630373635,15.23184929743953,16.842997182879625,18.16923354194659,,20.272444124084853,16.085585106981167,14.204607709046385,18.92811215311448,20.357980672701792,15.26020515590493,16.271324811795523,14.319007489355105,15.512268468033788,17.837488962992772,21.382065510521656,21.174905115847462,22.50570338862733,18.02344168569009,18.355236015223788,27.30487838096699,17.07722010468115,17.815404405431934,16.93100634973435,,15.68704190044822,,19.949917345029743,18.380037307795504,17.102603217599658,18.07561493894088,15.792728247365623,19.723320243878245 -Sample_024,1,68,1,15.110139013452432,16.78822286914433,15.560087075358265,19.86081532981632,18.401733943051163,20.48354113230157,14.211338179298696,18.251051100009626,20.112427734233652,14.756237049224376,18.152420710061406,14.37641834653394,18.173254257293724,23.537955481240633,,17.037317707584958,15.996190374313649,23.290879026793906,,18.326343898301367,28.663774049065978,17.259343440933904,16.40191254158975,19.38515436381704,13.346685640056956,22.12231189162011,20.95343556928154,16.207839656650087,16.7871987436828,15.413810999748845,12.693533430284916,,15.826538789558185,17.835060117780152,15.052870490916003,14.73782600752088,16.98048216726709,15.326158575618408,16.49380659675366,17.20735845395397,13.768952986556332,16.812791405764365,26.6054450557709,15.064133896708448,20.120249586330697,14.8296336128136,17.8429585436853,18.66310766075299,20.758313503984613,16.269763190057816,15.374985589412116,16.175950901270276,21.14027871661011,12.63722661051255,16.400508541097487,15.408080132485683,17.92914045511458,17.935872375213183,19.499404936001383,17.02619972133307,15.743624574231028,21.26102832463652,21.81550525823455,15.4170569673439,19.57374286625899,14.449129371379826,16.025854304865632,13.971299189076662,14.865045748623066,16.649039916363808,18.138226326449143,12.671031758021034,18.349431208350275,16.230278932398967,16.058908988549064,20.1105056121611,19.276862175292717,,15.415566807763339,13.811130745021085,14.93190251457347,18.346064866295553,21.358634568908915,21.414062716338368,23.047246085496678,18.51212195549496,14.97276344339381,27.196566568250557,16.630471665063954,17.797981654782152,15.600306880409983,11.54167435397381,18.453781288427397,,19.430692705198915,17.479746472173797,17.460003738365273,17.795762540423027,15.916619635800137,18.749069346036332 -Sample_025,0,77,1,14.56426359652994,17.78246068272838,15.692362008381025,20.61516038234341,17.14291911768979,19.026210361211962,,15.133477457223275,20.45953830647508,15.230212369896053,18.513806132715466,14.4823723535007,19.210663021252646,24.667361118294036,,,16.23909837106796,23.06074408087327,,19.343425118735016,29.230092874526097,17.05750742093851,16.235075800424152,19.676637631011417,13.064683731260333,23.35047159109115,19.494528834326402,,,,13.34182459150182,,15.912314305767566,18.342144811895782,,14.66711804059303,,,18.119182253900103,16.883894120699146,14.157009171297004,17.01924762889857,27.059604899318266,15.08331018666672,20.128798003316795,14.586194287736598,17.813522090229064,18.754591814578195,20.259987297934714,15.768131006014256,16.436557405682507,17.285053201800856,21.48012997557943,13.008022998572283,15.344654586326062,,,18.845644426276053,18.26588841348208,,15.8111802437312,20.65258012703046,22.417448872470874,,18.7221010415451,,16.21326563262968,,,,17.896788407448597,,19.499237765106546,16.140009509729538,16.86144069269159,18.550858669746994,19.815195445698237,,,,15.708557595158863,17.351710570048393,20.969726843871804,20.35296760739282,23.32991483487947,17.937429050034616,22.961715160125834,27.257081208880848,,16.77467718756002,17.25675232463707,,18.98027121839254,,19.61109325797363,18.562448803199423,16.272648008070668,17.388190756639045,15.669802023700615,18.964403888847187 -Sample_026,0,72,0,14.664273768097168,17.8092327327542,15.747281293596428,20.21632461205757,17.38649931050626,19.456756467004233,14.784787785794864,19.039973925665304,20.154898437799876,15.304330987716671,18.270024219579177,15.091102659421916,19.94868047059014,23.90833031195714,15.517090727154736,20.7104834937687,15.496345588539159,23.463698851543107,,17.97499593403698,29.319486630444096,17.067017084931646,15.957246784866074,19.648813860294563,13.924319872518897,22.729561416624083,19.983653576049566,,15.342563704823306,15.406928212806628,,15.495237777281806,15.092008316847002,18.213050510213442,,14.427308367833026,15.417961549777656,16.265920167043777,16.69360616729195,17.388615410435094,15.801632782460963,17.105439390985282,27.032682587741874,,20.05480368051096,14.454355652815039,17.842763414327575,18.971192957266812,20.686243712522455,15.625164805091666,16.570150215305414,16.435507111328594,21.65047746631421,13.68709798138774,16.000260186287385,,17.885831335229422,18.849050927954643,18.57713581908396,,15.866759932030757,20.926650434171886,22.00146781291837,,19.045486056438026,14.576964619909154,16.744071620746954,13.609358783273395,14.556492255796064,16.90879911974897,17.974102686924372,,20.423526433569513,15.925510615375808,16.3568205322043,18.809093454064794,20.008919937249928,15.936949692313377,,,16.05238595924024,19.69187905592929,20.84099626839824,20.81549714727179,23.37240797766969,18.33804809657223,17.35368084691051,27.107989017809984,16.79498454271599,17.341172126069516,17.16700277216659,13.007980240716334,20.30626059959799,15.669835968924485,19.381040012043133,18.37101857308815,17.02767301968112,17.24087007020902,16.268718028408884,18.829271551403465 -Sample_027,0,80,1,16.110081011901617,18.514253421650455,16.289022467343816,20.435924040800742,18.42089120485026,19.848165592564136,15.382203015518977,18.863010432235814,19.93033119834931,15.08998800615263,18.10776877151562,14.610090119453838,18.609426533950707,23.560628925604597,,17.17772990269302,16.169713714839325,23.16006744621007,,18.168630040790145,29.2708969726149,17.055465320346027,16.618311785022676,20.302892121034027,17.55636384975853,22.411970844306943,20.30341914743861,14.658272727709088,16.492453947366798,15.887496098470518,,15.694275090716095,15.915236050215885,18.030847107660314,15.123976913147338,14.706751360572934,15.260808294303766,,15.700097511460049,18.09262231030088,13.386046133251865,17.176617846427984,26.835201647688887,15.127403073798343,19.560215150454702,13.887809079272635,17.565900804836257,18.457818583129537,20.889979856010644,16.53417141724069,16.701316721797664,16.479002604251917,21.49408527799394,14.194174761804677,16.591808112192542,,17.662562227442944,18.63461864521816,19.055226489623916,,16.270467433657654,20.810831070032435,21.25317764906957,,19.085242273738437,15.357328762255312,16.624189147901614,16.42897808759508,14.273522303733692,,18.39584095563309,,20.051227199164728,,15.833869777338627,19.015995673920404,19.149997310765812,15.962831241903633,16.22014004991482,14.33292816387309,15.412735481699128,18.04748507598549,20.794910298361142,21.300650981144056,22.622831589294492,18.355037962646215,22.144950070911506,27.32201010248359,16.910297970648994,17.30092644542863,16.351331398266716,14.059241960036486,18.44565875521796,14.983827420981594,20.07634605642367,18.08292345855929,17.679018595406777,17.771333803029325,15.672614389101255,19.136465657363207 -Sample_028,1,75,1,15.156731806332008,17.51714264309834,16.125856279555766,20.06322620308637,18.316063414819403,20.253448621666763,,16.226584764616707,19.463242469576535,15.604486493406869,18.211324512858923,13.910717838385935,19.040781341041335,23.468663440364786,,16.688112829866583,16.33334045896024,22.834057527102594,,18.461380897129477,28.751263525319025,17.682301331246975,16.386961815049887,20.171497517847786,18.371554661908828,22.824566273937954,19.345139906361965,15.416139315241304,16.668607702995768,15.12343090815906,12.601650770070542,13.882481201694379,15.973717770777982,17.827835186051395,,15.315187161439642,16.590592760352322,16.549535930451494,17.530716848300035,18.48291231457263,,17.46568745994821,26.142543078531016,16.121022327694263,18.902625456373844,14.108166130048197,18.189397187020223,18.407195917779855,20.44548599645507,15.855785538506938,15.904096268828575,16.637197528768986,21.242022850299204,12.932414371816298,15.874530592586664,,17.754173100472126,17.752252514286667,19.454090532030403,16.808630763845194,15.896198975295842,21.530231049733313,21.791732749015438,14.692181279402348,19.079283593967457,14.614815641154841,16.56042473516925,14.86223816958218,15.252214548670752,,18.060102674414036,,17.65060061199547,15.648133065138834,16.270455741855965,19.487425207607224,19.70231348211579,15.033004510995369,16.002465670850885,14.396949905505851,16.906512459397675,17.840169091342442,21.149556889307156,21.359800221281102,22.6811302962065,18.34221712301983,16.932513585672538,27.14309403761984,17.03290516468904,17.63778093135484,16.937481044978462,14.696782068115777,15.888808638558272,,19.991897631594203,18.523986735528638,16.98255227450037,17.672769320218357,15.448257741341827,19.56241188542628 -Sample_029,1,67,0,15.946857740728413,18.20528540782507,16.26939353140391,21.520974094122625,18.274137394662702,20.133584537258837,14.633317881948809,18.295975992692817,20.42336754754485,14.969970597194143,18.337436389099988,14.106356705012944,18.13944893004528,23.562594368808167,,17.018569334713323,16.099788741022962,22.716185618261672,13.665208058091956,17.809197595353766,27.723222118712073,17.64971151400028,16.344119651445588,20.623704141240903,14.806761509024671,21.878294564336816,19.42709924510519,15.526839837910618,17.010893255786357,15.708920422656806,14.246632464206245,15.909470778458337,15.787524888978686,18.366997145577916,,,15.850131599412913,16.353667791522188,16.3249358919755,17.554000682864817,14.362409266643835,17.5163548100344,26.533295404067474,15.612558752940586,19.441766290628127,13.805409519121774,18.076489103915723,18.578641841934886,20.435807836523814,16.346180410778338,15.506468971139592,15.920420099241916,21.08029674574709,14.167404363225813,16.14952091794134,14.396319161684822,17.965505563293974,18.536260260831703,19.59984169280577,15.648388743857913,16.268295553419037,20.753833207343238,21.316366200299893,,19.050163519787073,15.41256945918175,17.30176103376687,14.545303057505967,14.30011148843167,,17.99057489960908,,20.265710609230553,,15.647401332231718,19.919243334239667,19.34407534685551,15.032469035844215,15.445931237590786,14.396735551475087,15.558050694188717,18.33596464326177,20.851163889902228,21.054640417209185,22.747040095810995,18.0313205828199,18.650972943222197,27.506135282151455,16.85558291715008,17.215433165931508,,14.216979518314615,18.15268250568784,13.745340424671095,19.900297561204297,18.022840523821106,17.225076635693817,17.303739506583355,15.80106395741356,18.89838291668005 -Sample_030,0,70,0,15.963256739166528,18.252566691857904,16.544938499322157,20.42339550454658,18.81114789823173,19.90513962146765,,19.718754015948505,20.353379735370538,14.94290032129208,18.385542523724997,14.214046628224272,19.434851402101906,23.800069257651145,16.14654707935277,17.161633517671532,16.151367012994463,23.0273792565992,,18.421296068728,28.301751411014294,17.608909699601167,15.875685616665022,20.524588222691655,15.099293226435595,22.644333589651445,19.025658503992553,14.860714469995498,15.911609594670303,16.239330333154278,15.106652709943804,15.720370567745531,15.781027267156498,18.25653092130783,,,16.70171204022893,15.410893694331818,16.73908300341487,18.052074791502672,,17.441258711397587,26.50386213910961,15.783926436964727,20.216053534485894,12.214448974018506,17.84537748914261,18.46910966251594,20.402354386829664,15.846300504611156,16.613502961879824,16.190795853720235,20.798988766533952,14.37640032826579,16.03044521354911,14.49730013863391,18.410817112359865,17.345145186569425,18.990503749690475,16.59187110083409,,20.871807029836898,20.78296692452708,16.373797372730063,19.291886066389804,16.018225652585603,17.138278832063293,14.852216210617533,,15.54414459181512,18.61565882001326,14.717137010789493,19.573694449898888,16.03411719278725,15.36181610154843,20.176800586112662,19.146327679015243,16.265624774718063,15.693576392352288,14.432143749669779,15.26546625356091,18.49325359339609,21.060832625009713,21.11960830017765,22.624550955324196,,13.922860382154221,26.6327307996264,16.91392178746771,17.697202603635095,16.735235994573102,14.701548870815794,18.08241074601783,14.636102611488935,19.716872408533423,17.982993226650326,17.51446124217865,17.578478422735017,15.465756451851334,17.687164421127214 -Sample_031,0,66,0,14.340316836887737,17.45746567503622,15.485491294654965,19.990804511603248,17.570236164792707,19.511425485881627,,16.455450768134632,20.964010733512133,14.541038698740776,18.95743438034288,14.773497018340969,19.534148614466837,22.968147948055314,,17.506611337761363,15.623017085640981,22.970071388045,,18.923672047200224,28.22331223983876,16.850144288175105,16.121634057920243,19.844039092057745,15.1239158352571,22.434359456348716,19.089099026057273,14.34356933800646,15.883594178770213,16.95058535227366,14.311092359657867,15.058346873229366,16.027122228117626,17.9355192952882,,,15.775262036751577,,17.890627678976802,16.520376373766787,,17.21149266048464,26.67493468512256,15.51661378218995,18.453484286883512,12.406322191183897,16.921390968806353,18.345971097987103,20.151019017134406,16.642176992453212,16.428884446294745,15.26180440634478,20.719203088941445,14.530766133426024,16.434805472208446,,18.08653861400483,17.7808351899244,18.73268375762408,16.23193921528305,,21.389454364860953,21.71379385001279,,19.051166448092918,14.897001209040669,16.4161733414082,,14.938608847053526,15.471230529534596,17.591443819585074,14.428267641573152,18.748654348405765,15.667990309233696,16.838779696161076,18.96534499886507,19.555845899563963,16.05558265235003,15.075128028808043,13.842640474074969,15.746930242163428,18.285341397459163,21.02277619549735,20.738159588250287,23.360269621689625,17.80919896945813,19.532785375319595,27.025038331257168,16.58580210497351,17.663760692765333,15.756622693178242,12.685441232856572,18.689988803424114,15.41249955604846,19.43344013970677,18.13530628960745,17.27601617863534,17.526838644224277,16.04884886066281,18.969669587478858 -Sample_032,0,69,1,16.381976296815054,17.860136355115802,15.657949473191685,20.284841322926315,17.759292291642506,19.12016872907886,15.345541147061896,17.400222259982435,20.73324418475338,14.941032915483252,18.678324826425065,14.629855735091807,19.467106484775485,24.47229946451094,,,16.041797159318556,23.198710006816608,12.75377721366416,19.04054993262412,29.281761972021673,17.213675463326062,,20.288741904772277,14.601700297261,22.626909571100317,19.25379902140618,,,16.96095881622629,13.400300970147832,15.32735897835054,14.430297362126899,18.349289463921817,14.035277688087774,,15.092518114373119,15.383546760123487,17.59416750868817,16.98948891886791,13.839055932518132,17.36253675258388,26.943346504814947,15.064651829148948,20.457344554313675,13.347142020415516,17.07959073905111,18.82030568218997,20.430563190592082,15.622904517554604,16.883367736299814,15.693327853973617,21.455512726210085,15.638302996567804,15.868064610819339,,18.050568262019258,18.817484337630724,17.961714630302772,15.478623861456347,16.099727111935838,20.380891037628423,21.621067680246234,15.665351315904287,18.92623897954982,14.47928872422096,16.58345101361272,13.890308628653427,14.436110024447494,15.933059725445242,18.078203265148662,15.285663679354792,21.582993217146868,,16.900202833842926,19.535780714986213,19.292330761294085,,15.50723233257364,,15.661239012780332,18.28075576387502,20.819322606066514,20.856875707847962,23.195643894752347,18.08131763951379,22.832846082488906,27.036663629432724,16.415774514623838,17.32079834578085,16.336382746142394,13.431302989960775,18.663188464242413,16.744401912787406,19.51237879481609,18.45222427039407,16.87788639655154,17.191837565428926,16.020738551075063,19.032773869143277 -Sample_033,0,74,1,13.605517045556796,16.47547888964861,14.933371622460763,19.23802724838898,16.54420250181584,18.3997542106985,,16.745194838835985,21.42708427919726,14.506205628500098,19.350927045261766,,19.395550608931387,24.61035831837706,,,15.512452461882312,23.28595429218273,,19.61311386118333,28.18196963050207,16.5398305483826,16.51032654185159,18.810939301350658,,23.372648027104514,19.606849655952917,,15.416868382215016,,,,13.814053451515736,17.344975668722274,,,,15.613317137510567,18.16523885934765,17.063955233500128,,16.935252382526034,27.089837897876293,,20.794187876811044,,,17.814774795579446,20.05874255654278,14.066787219788703,16.070308510161187,,20.96056374869142,,16.438370674485434,,18.264597225316727,19.749841507211457,17.13593281137843,,,,22.86583925398631,,18.17317952002209,12.971073908694061,14.633914492391819,,15.429711677552044,13.675758626168518,17.40364296893803,,19.110097265318604,,17.072395804836347,18.298104811175854,19.360022813566342,,14.735372051872552,,,17.16525588341003,20.511722618216105,19.592444034251756,23.801710134816894,17.92825070624461,21.1798676427868,26.07429569390997,,16.23819799908845,17.449175351401294,10.853590447679764,18.9726376009787,15.321323414770262,19.100728739696674,19.098035135963187,15.812873155097055,16.40347017560329,,17.881845389063237 -Sample_034,0,60,1,14.72053746716745,18.220296691722798,15.560324320248831,19.563215012179462,17.548935117739,19.087918260353636,,19.298777462462116,20.28563009992526,14.987042512592648,18.722400961446017,15.249997350773581,19.924015348366193,24.112898322678934,,,15.269275951252732,22.663284141016906,,19.143825990870305,28.608350379909933,17.27011777931917,16.888107031163862,20.688817592742932,,23.299377968730038,19.35843832384605,,15.940847475337103,14.993474862765407,13.432015130135454,15.165855431707525,15.145688866247975,17.533981977007365,,,,16.6004428910776,18.490831172819952,16.47276643701086,,17.46426342286569,27.08526854631928,,20.94389623720673,,16.877695279690453,18.61322472228864,20.29144095332188,15.58579924026081,16.130261354880382,15.996750514651987,21.960976221097617,14.653213663527309,15.879762246522493,,18.22368961905805,18.86381516950463,19.042383962235686,15.327548943705809,,21.455796896570185,22.142090537132873,,18.522638637250267,14.105668134833559,16.817599975019736,14.176335551047028,,15.479050603326415,17.966697039374072,,19.657820085696574,,16.655073069673985,19.072240082211106,19.608072043853124,,15.6060273000016,14.337159912932606,15.88240591535298,18.015225487468218,20.5401890667614,20.442026596319646,23.88775312511158,17.323239794826222,19.492232417255565,,17.008573606512222,16.948203143841827,17.185533639208813,12.366753753189744,,15.75434225235617,19.488235614415263,19.911954041232896,16.47491522631732,17.26290833704266,15.74387065694643,18.522705796754988 -Sample_035,0,61,0,15.957255819768257,18.45664318192236,16.336447446579285,20.6959603758979,18.18602565261813,19.671959524270555,14.904431763693887,13.598048182613907,19.895672717508827,14.602553212803073,18.425388673104006,14.154044252371738,17.779428012552913,23.507018022142724,15.787247774815595,17.46482677644943,16.14099900761732,23.212124524262823,13.703360992780397,18.250606794741,29.112184468924834,18.06059781450331,16.6477079675674,20.48125437222042,14.837543628759963,21.379411552627165,19.345219378210263,14.558057235754047,16.088952857624623,15.86435648156854,14.269558327259235,15.924454893909639,16.27189639916145,18.527938088236805,13.94338986911193,,15.534442410114288,16.057476186069753,16.746319951232707,17.70784230101743,14.542127260259202,17.618660284234654,26.57048461631186,15.35900136694091,19.196539845036263,,17.825082905521484,18.862685214863113,20.566332349136047,16.35315948168266,16.211768902903994,16.61335558589558,21.729261633119414,14.695831911023742,16.411935555496758,14.284714124191202,17.93625134321533,18.129607212037488,19.56125938961588,15.816797641203465,16.22744261350562,20.549722281986263,21.690888907862103,,19.082653888997914,15.356261205105866,17.68829748455801,14.508516801677423,14.457635252013134,16.250451674830327,18.504110736738358,12.598498614980484,18.945699584353033,,15.875657310032636,19.9566565591791,19.521424558374445,15.332146937520328,15.594532822733225,14.40910913224172,16.684662595603886,18.426859771946315,20.86965492989094,20.928375148691586,22.731277592727725,18.10339619218502,17.93932112338178,27.669031886311014,17.08501886147865,17.199490232964312,15.686401996126765,14.134791029123623,18.11831805912801,15.352903374297837,20.062380527193167,18.152596483523798,17.254950312493886,17.2475142614178,15.689315542790272,18.901364104723253 -Sample_036,0,64,1,13.598976385338531,17.336459432867972,15.631769335183554,20.225672134217717,17.925687987726075,19.342459942487185,,16.255193429554627,19.983387419662034,,18.329496084869405,15.106818337578794,19.566469626341025,23.8556092443289,,17.16893648876924,15.626318523773692,22.91919431563272,,18.752604620965975,28.373085251658438,17.319731787734675,16.30715897019114,19.9581869084557,14.276772742904257,22.164981173330904,19.860980951915305,14.139309961263244,16.36184126216048,14.65826139431873,12.285948649772477,13.833020063393962,15.575842733860688,17.86710073294541,,14.62739194288302,15.842164245434015,14.808303561231577,17.880281165291894,16.601528361482163,,17.298646313083083,26.725689640865525,14.896248319448429,20.58278964161906,,17.534663133124045,17.85612162572387,20.306203015837887,15.999485164075475,16.026493386960542,16.761079938860323,21.638677078676828,14.31412958711369,15.768669858958447,15.357467034296963,18.00495250130781,19.235189479951153,18.519601222316787,15.540885267588193,,20.642202778340362,22.271557634183985,,18.714305792231297,14.407583120122,16.713565446103814,14.032789336076851,14.627865583695318,16.005645449284327,17.703548564176504,13.959819268022592,21.414148806241077,,15.75887819203086,19.558092512970077,19.448090462230205,15.542856407575353,14.498311160645768,,16.333677579623203,17.73506045446946,20.988027763926286,21.15023227122627,23.493578189429588,18.49336953766129,21.7148549609551,27.073697208161736,17.199313790163853,17.00393886823872,16.713156892552863,12.386190760158243,20.924362283283386,,19.4120821341315,18.423651196204855,16.45254113718104,17.812557488970583,15.751545591369908,18.904689190004575 -Sample_037,0,77,1,15.7889366371138,17.580595219698214,16.10523123613568,20.20478111803611,17.670472131947353,18.843985055112277,14.87854219721084,16.812697706520513,21.46244173733454,14.661994414496343,18.41918585634259,14.819852615061453,19.766792342221834,24.053814793611586,,,16.087923438422287,22.915560576797688,,19.081898013692708,28.98684840417538,17.356333752558893,15.679869637113443,19.624109477834054,14.559604066975746,23.012583110596495,18.855455836610112,,16.007794143767665,15.556374258323837,13.536065401545633,15.586930588365709,15.829445383190535,18.5271165077593,,,,16.232618543579928,17.6713613820523,17.213488732615225,,17.31673575557603,27.167902300730102,,20.39028167809406,,16.626139468629294,18.522686762560426,20.389854101836377,15.389561234787818,16.577404047914285,15.963167291938824,20.48050302286778,13.013987598300929,15.669316757521,,18.13872380292313,19.08165425572086,17.71177797019946,15.422324672224121,15.712715902507238,20.439689126662856,22.194757004686945,,19.018480705161142,14.877910541738483,16.4268225425807,14.008212828150043,,,,16.306395648144587,19.694770629714174,,16.766148027525894,18.95686815388269,18.850253044416274,,15.454358665271279,,14.975632404868433,17.78989696338613,20.956576627140894,20.429174931683747,23.872505710602056,17.754343373851604,,26.540017462782888,,16.747118381925223,17.491309253489234,13.378111589069436,16.69332827940751,19.0097860838135,19.665538689965597,19.846110227642573,16.887366219856144,17.117046010120887,,18.895765616792094 -Sample_038,0,69,1,14.70551522184308,17.72450427735438,15.843371823932335,20.31030101899442,17.571620844081874,19.279623332340545,,13.266616567152564,20.75342875971105,14.88510043546859,18.934792183792872,13.948378639489986,19.140926947904067,24.686617377148462,15.33747150635685,19.61697817478063,16.311604482167823,23.518103351697476,,18.905772504538792,28.768952888783442,17.70327776072354,16.33192628739172,19.807249566552677,13.243932714415719,22.879506690106883,19.611877283758062,,15.865208619901505,15.044421469552287,13.8460083344841,15.937190783258819,15.45766180140426,17.60795683660678,,14.107198554359893,14.736726552875659,16.224909033858346,17.1720212075525,17.49904185607427,,16.99639107747876,27.110078950333804,,20.1850798825637,,17.99560483055112,18.343676002196545,20.435323339286157,15.737300680642361,16.133077286952997,16.58372633325091,21.075422349146905,14.851032891732949,16.144617015023602,13.908693039783541,17.573549884463105,18.36521683258201,18.146817865349128,,15.438107677208436,20.62321316541891,21.833168828425876,,18.854153685580805,15.051818143725678,16.523506083046087,,14.037428816189749,14.585878762572618,18.19492454008774,,20.883128203710115,,16.066185785001863,18.78281039242166,19.248030047666667,15.844615456011189,,,15.718766346947765,19.684402028944774,20.723550337527325,20.794601186670118,23.474791725440763,18.141172123386628,,26.934789675955297,16.656821547777703,16.932891454988926,14.925519217396694,13.764302257746545,21.154601199089452,,19.498059841513324,18.795141543561517,17.212175595872896,17.08037352490628,15.817663791179271,18.717975695759485 -Sample_039,0,79,1,15.961891933557967,17.806839176757176,15.96547782030606,20.23329140738378,17.319754248264864,19.121843178852696,,14.968079024209409,20.148877778430023,14.216466274608175,18.915610721907196,14.873624999054487,19.5686859709231,24.319872676995487,,18.402917462026657,15.003684490935253,22.997565596617672,,17.876553573281807,28.476925149418733,17.61213080494241,16.18253014285739,20.146951297699914,15.034545603492987,22.913891847928156,19.754075107698455,14.208327099801865,15.41394512497732,17.326648785302233,15.112296002416526,15.531199627140136,15.936707572746407,17.73172630614538,,,14.773625692106855,15.78585063187586,17.626887631152936,17.032898104285074,,17.185028145242836,26.4691024719902,15.64481699137254,19.880618787443595,,16.21291593112337,18.212714706773312,20.745883446159002,15.834508856286181,16.7861868554583,15.694512413816325,21.07769930188247,13.857059917911064,16.235841868112395,15.583491758263792,17.988709387061125,18.359391532311523,18.68055568903626,15.682354917502499,,20.630791138351864,21.739394969512055,,18.755104973758165,14.804415054696058,16.55051805876172,14.662785813774866,,15.723619493859868,18.27979248876401,14.743956714366805,20.78443076688411,16.071264306784336,15.732494968009583,19.945161067794952,19.368751423101195,16.203705108542593,15.589123747971673,14.372302752487531,15.324636685179842,18.06703251742209,20.99011695127946,20.37666633983103,23.1705867917455,18.291447136388356,19.743228761353365,26.2861792829393,16.693321472450176,17.203774547915785,16.083971215928802,13.125638123612607,21.017261071515634,15.744487014648051,19.806967761735113,17.980125192325513,16.838019556873206,17.831995668608425,16.14767571780945,19.212334440777767 -Sample_040,0,84,1,15.271136560105491,16.917716609755416,15.266722928047079,20.742309641700135,17.664565229095064,19.13875801375058,,15.742853085554538,21.106816900197988,14.97673987334592,18.911402137463014,13.76104624739478,20.309178642705746,24.37395404885668,,16.899371122317167,15.684343274559506,22.883889647194362,,19.371288237900583,28.857020801945367,16.678551141155197,16.469471658389097,19.620329135025212,13.230025861239708,23.634154751840683,19.75325103210811,,15.693747589864078,14.990794559334407,12.81749321813009,15.383014582248533,16.245609135861475,18.21135407379951,,,,,17.583293877689385,16.10771546288871,,16.926638672198695,26.938910497292582,15.055497260750762,21.915329886842205,,17.333704600460447,18.573412354736085,20.63793146996314,15.233306476642316,15.987162680063758,,21.76836920847993,13.430718606725113,15.549504438659522,15.236472064255263,17.982170128807212,18.97556821067565,18.33555473305568,15.605440407043,16.031429630089605,20.848500020945867,22.229824809576396,,18.776230903176227,14.04855189528599,16.102718539856028,12.731337159905886,14.59295745028292,,18.35884862399139,15.169378986978534,19.986035836277193,,16.884593680685786,18.70468529950444,19.79464798397065,,14.621052136998204,,15.321619318591594,17.881809083114433,20.739711193893918,20.654328458331438,23.758223316406994,17.618887978683524,20.10473534849669,27.00848112291032,16.895792422438358,16.514621722715184,17.771690652347978,,16.68304771571807,16.588449187881356,19.128738387601484,17.924955178453594,16.588784506197616,17.30536027748624,,18.349118542119136 -Sample_041,0,69,1,15.904199838564747,16.89931801217904,15.316561899620075,20.492961675581803,17.774300563528726,19.04641696761594,13.92271323597856,14.395554531158208,20.506788429010307,14.977022286865205,17.4268700066551,15.348130417086963,20.136171638349733,25.187995993001007,,16.815879583295146,15.478221932411602,23.41614653298013,,18.236819751595835,29.274665932266466,16.93999136457583,17.159773118112025,19.3220426995738,,23.84493998445942,18.150883791825688,,,16.699834529800643,13.824668624601436,15.161081586870317,,17.905646556034625,,15.043005582644149,14.351462967203092,,16.88589574017776,16.342291329729722,,17.2018494664373,26.737022222642167,,21.64893418663867,,17.518270512352327,18.32081252818327,20.540816466502882,15.690431998664721,15.578197146346772,16.44444610238173,21.46297847794654,14.152255593473786,16.685273645794346,,17.86959854954616,18.881453348484097,18.571363459136514,,16.2935617358824,21.294937740529182,22.00903342538714,,18.8353350430343,14.02240608262952,16.470430992504728,13.02078923908862,14.68866416218611,,18.12073020577096,,22.67998428801672,15.836707246952086,16.183609032839833,18.816744917520026,20.124834571300102,,,13.867176067937848,15.588904227519402,17.67315290812649,21.004690245755935,20.68398791471162,23.31972586250584,18.115323747815097,19.778815781012636,27.290384533503136,17.154382711217284,17.448054533138635,17.063612322417125,,18.478830337353873,16.22176100857946,19.451070342570294,19.363467072183074,16.6992417983496,17.257755843123295,15.95339897824966,18.779007325467536 -Sample_042,0,60,0,14.19773083137054,18.260361528061228,16.182137439956065,20.551950994081267,18.25296045910126,19.527361503667994,15.152191058237202,19.01818387536285,20.272571127828723,14.597052984066487,18.32383886329516,14.53823180424989,18.95229663806669,23.7929567654534,,17.816538983785563,16.230264271318433,23.117823638748728,13.051490424251908,18.65046322280811,29.00287217574155,17.373368997986137,15.500219464843928,20.541858652248106,14.904190281420453,23.329793601462324,19.737508750705118,14.180723066542862,15.671369805270666,15.639397570710802,13.658401093934662,16.36023773463303,15.917371624176267,17.8565681005784,14.166657455387888,,15.024695331035952,15.58217047148716,16.496603666988783,17.343810032799418,,17.35996425408471,26.893340708374335,,19.631411221115602,13.252357928533954,17.286592729429298,18.53411298441115,20.295152346806333,15.488397935384377,15.937425727323381,15.280016158472089,21.871391287660185,14.85685965956888,15.735140529855887,,17.839240605432725,18.568024290415302,19.013519644430545,15.690120028131696,,20.851392202528324,21.6151343331178,,18.769639832108826,15.150301698127711,16.985220641256394,14.654233606406828,13.81486581812275,16.00094232909052,18.264845163552042,,20.595952533903954,,13.80433341556066,19.725336299080432,18.38276780978847,15.113221688684137,15.818210406320238,13.918477307759831,15.953226490547884,18.35671792455035,20.38044864615927,20.60936374349748,22.881429075803425,18.032000479179157,17.357179735799782,27.48818829545697,17.097915903374375,17.37817206308487,16.81934687438314,,,,19.87039011987439,18.048027484081768,16.9430007847203,16.92783880381163,15.471604892605711,18.221271740328557 -Sample_043,0,60,0,16.062203952853405,17.961079674146596,16.22619446412524,20.37678793635245,18.680825104874728,19.88403428348951,,,19.250735735411155,14.793155572554413,18.36658021935109,14.669988063990079,18.321413155736412,22.920984642017572,16.225395452160086,17.903621149623586,15.867662869083201,23.317766723016206,,17.192219809663214,28.212990719957574,17.490703029579574,16.712916216621668,20.57597230221931,15.172337619425694,22.174726097409348,20.69864553829584,14.948466602105398,16.877700895630174,16.372107427827796,15.471557017259178,15.909644457671726,16.053437395293713,17.77586091217386,14.428909869295218,,15.892164514509213,15.431268298416944,16.7624132657485,17.71102340284531,14.070332097481787,18.106243270946187,26.35988667921212,16.108016295648085,18.34388361559103,13.300205212361856,17.372921504596373,18.416026017787367,20.904669071615693,16.34192242908634,15.989354218289256,15.393354056505078,21.382286409478162,14.380511928738683,16.418578014740227,14.952239574567066,18.165703344830504,17.324591503543342,19.803488686527626,16.362721072250412,14.74126874589975,20.508246577609395,21.09470626064439,16.207358602911857,19.30775683224667,15.71991809909083,17.413163563680552,15.094245890948072,14.382233761004802,15.457981983647851,18.392759203130147,,20.125058841478314,15.840939620986225,15.701664772699438,19.24910187598794,19.316546846768652,16.260291313459554,15.761229612817143,14.454068059799884,16.094280528488444,18.691434494601687,20.686943192699577,21.1920525620448,22.53622242959036,,21.295003625669185,27.444882954561578,17.2124947524812,17.819655991677646,,13.276197403960063,17.56872643898813,13.473302819522926,19.841156789321037,17.08134559904134,17.814570633909742,17.94485162009034,15.871183888760727,19.21483890812264 -Sample_044,1,77,1,15.792280338250897,16.5733198904067,15.691985517351933,20.880351891249674,17.344968221395245,19.476911305560975,15.05942714938956,16.518696132172973,20.16432555373398,14.857579187706321,18.718476645118113,,19.645970713949428,24.25116793506422,,16.669118192483744,15.519293588971289,22.883370533253572,,17.586645572706658,28.3979532011182,17.099700148382343,15.857389348395516,19.902897645829704,14.047905875952953,22.927585204329027,19.397826844735622,,16.15424115544237,14.961099021075306,13.873382622823565,14.844300721053932,15.635809991381054,17.877990274136472,,,15.85491393157054,,18.062935146304348,16.8671032787478,13.232471138946025,17.161699169389472,26.430397691646366,14.84396311400171,20.518891551057976,13.80781104621152,17.438895764024803,18.443298329513535,20.505316688927213,16.09108877395312,16.240957244660574,,21.385057570910774,13.409485203830421,16.59575407919852,,17.440884117898637,19.41975217281037,19.56090327193082,15.793377969798945,,20.475163928463846,22.058519296161364,14.931250510178728,18.529370141589755,14.233635473936772,16.691792284058955,14.782585260280838,14.692884483671007,15.650138871071528,16.95795222272272,13.784247630622708,19.106047216679233,15.047205806042355,15.923576575559247,19.3365141871475,19.270684997948177,15.554322554048081,16.024863032569332,,15.223921421064851,17.9264082991463,20.63194891379377,20.30724473178245,23.17515494274643,17.972496058962847,20.277511174748795,26.92566192423051,16.966021837809667,17.506404804718933,16.4979866536321,12.563818052935824,16.664610472972345,15.37224575230922,19.139149584019936,18.33095652971878,16.726995579438533,18.036098973428143,15.424661209539087,19.0849428155969 -Sample_045,1,72,0,15.944005123811872,17.887206295980157,15.641552590872204,21.133413644403714,17.786769949239517,19.60273884318609,,,20.905561268333027,14.40729655370126,18.810336671220057,14.734442122842173,19.492870263469545,24.06120941270013,,17.992281791635197,15.808904194099798,23.314705071180985,13.865361088521414,18.031754030637302,29.098793368519903,16.97709541526579,,20.411672865870912,14.749446066643614,23.227706566101446,18.862742055171935,13.872250838439625,15.713989820685589,15.237023916821977,13.430629289154512,15.960258913421997,16.097461861607357,17.944587858220903,14.134385895775138,,14.06403370984411,15.3427547978849,17.41810185410146,16.702490938325123,,17.475506968081255,27.035314284665496,14.879147208069819,20.046708045597754,,17.36674748445982,18.70324628338976,20.42827454327118,15.819861091284695,16.7736169398376,15.203599524424583,20.918660641700885,16.185381344140122,16.54698392487979,15.331935441968987,17.69088848170826,19.18860499282786,18.899249961957135,15.409234370823812,16.945520458370137,20.390856435912177,22.155178626535896,,18.544092694931162,14.704580298824627,16.233508360265592,13.612550654156975,14.818637076802858,15.738025649645174,17.69841387544247,15.346346811044489,19.51323230631021,15.748516671774796,16.19062798884947,19.624628370104496,19.40119085205571,,15.062287301270166,,15.854681230224466,18.43852867826864,20.70250002721576,20.616630839271394,23.52861733437533,,20.813928627085065,26.995385136438852,16.37591401500829,16.704634119223204,17.356647276818872,13.522802280695979,18.194264503244806,14.861483667557987,19.106695516207736,17.721710541433694,17.13249690558635,17.247346783148817,15.340960863291864,17.92976651007024 -Sample_046,0,86,1,15.525253632060936,17.49311344600305,15.791091826524072,21.22677451100156,17.858149125058542,19.571725104320986,,14.597321855372522,20.05793836004083,14.920888538171475,18.113745344930784,14.288143433001224,19.784751349154703,24.175845626047412,15.101500944522297,17.704760430978766,15.754259055354547,23.309487872431422,12.576128507190823,18.137955954790243,27.898602223442982,17.40833375799305,16.771095484921346,19.880002899270064,14.363161043593104,23.539895492829178,20.321443572803332,14.77001767465937,15.619573980737098,15.597802629230406,14.231734329166763,15.859248886975827,15.735108396912144,18.39890361725718,13.106573642795853,,14.113991686950307,,17.23935874303202,16.893740628512685,,17.423525920648434,26.698228404424682,15.228501804032996,20.39278068603238,13.70530681033152,17.06404966782364,17.975708227299524,20.796004742940223,15.962828859542052,16.07833456323292,16.0188080301437,20.963751333373907,14.018679689571869,17.169973767254227,,18.098932438692987,18.351835096735766,19.769750592793635,16.38082209213381,,20.696793633420842,21.325275119336748,,18.725258070352037,15.104079446831928,17.019537113841338,14.72417928815141,,15.56721640847357,18.269866751683626,14.032749491574387,17.78993436446885,16.35548673525953,15.882152879675475,19.334702652095945,19.20627497435442,15.592777855279603,15.325461653529125,,15.261442602483573,18.456781654182024,20.745305748053156,20.69397490025639,22.813955823296574,18.467875162592325,15.70808203512159,27.007793983402635,16.61221080171482,17.394616946368586,17.099933334353647,11.953959820407828,20.849842685216053,13.540623167545656,19.46021389630221,19.141882148561464,17.312772882188796,17.648579211510867,15.803674520093404,18.641407611692152 -Sample_047,0,70,1,15.968864332468641,17.627287732167275,15.417308762194319,20.628762570473764,17.28186396642334,18.633968798073294,,,20.74873172816464,14.786044236809829,19.02997128252285,14.574705887065813,19.199075603092883,23.874549259605466,,18.17396879416114,16.1712937924218,23.146522530547895,,18.863517545594082,28.877190320291536,16.935671165311625,,20.271443507463154,,22.56153641286073,19.426022710813807,14.30097851664783,15.861219645344987,16.685126790584896,14.888072462234755,15.368170054405534,15.719968322387144,17.92000004657728,,,,,18.293660235838498,15.876426734087197,,17.311780044981518,26.825855432296883,15.189549209584747,19.644395536607636,,16.16496537322639,18.574390495483176,20.33983356040021,15.105187107286252,16.301806796554516,,21.289641116992968,15.650261169006502,16.590635245296095,,18.00070031533536,18.433088605049797,18.59411829186804,,,20.540642675954864,21.164537170528817,,18.46543711866062,14.529177447954437,15.883717499921143,13.445788815782276,,15.699329288419165,17.913188729098326,,19.630789694438437,,15.350674992006693,19.333594603384068,19.988282749312063,16.187121721957844,14.965634054810522,,16.20179264476073,18.076775319425707,20.765795165290793,20.173324567804503,23.06533181625339,17.67222245562236,17.553059723255725,27.419093514686452,,16.964274758832403,17.009315227046617,12.844449285275855,20.70975516864062,15.25716682468519,19.612002980921226,18.70834057060362,16.56890847326565,17.226468347046147,16.121425222871117,18.786070667204072 -Sample_048,0,80,0,15.75684723137158,17.839961382257083,15.926563121854006,19.909665788468693,17.997550781055057,19.47190190750235,15.447033268573309,,20.139350091825516,14.87276307358031,18.39290499239907,15.448864800316974,18.661571316493244,23.769413038712074,15.518602614632206,18.176908910451782,16.095331664131844,23.267328635361217,12.652435485945274,17.597622158915105,28.825460288996307,17.174394969026988,16.828205841673157,20.004164905641744,14.284181913753406,22.479383714854386,19.051593809116216,14.10646326100475,16.01335743496876,15.639905365440919,13.924019789805318,15.473881106115206,15.27636454851771,18.34752337604606,,14.930915511863924,15.138718647796608,15.489147390904078,16.600342727668526,17.446152039353038,13.564313958729171,17.287157596098552,26.94601421762261,15.073824821667117,20.095127358978665,14.699108328700923,17.612580124512387,18.997411834682854,20.6568445643497,15.312682048253397,16.6655297989224,15.819394142823912,22.26742065546476,14.185650836482914,17.111535923143,14.354173904156102,17.873711914150366,18.653319954895842,18.89225532348267,15.764874019840729,15.876038840476241,21.28103137275099,21.73670064776402,,19.020249379564397,14.97311532324805,16.635667533412008,14.570388359274395,15.069151439119361,15.434949109587322,17.931894311121194,,20.11268543561375,,14.86805094797214,19.46430705323608,19.432185813035137,,15.330267667403792,,15.974541327588206,17.997053337760015,20.909309531964542,20.89989621733442,23.023682960064228,18.206823297954294,19.73283133580842,27.277428886271007,17.1011051129085,17.290063717772203,15.900073080436568,13.90271183770493,,,20.13453426987572,18.668167600250577,17.291374624214647,17.073345806716667,15.67029155760391,18.67287169940993 -Sample_049,0,60,1,15.21507569237626,16.968976271099926,15.441736534797698,20.338301821225595,17.26037574287139,19.334667876505264,14.736080850556952,14.33642510823009,19.986385449042682,14.35711904674217,17.924341349920834,14.945900293328354,19.588618000431534,23.721023755633546,,17.11791825729664,15.409721234507149,22.749644823343356,,18.050753405777463,27.982191986309285,16.48498191316265,16.750588007254603,20.413877353922782,13.76381241515138,21.6596336127937,19.024837844772613,,16.12781599637624,14.896087806161242,12.997431648064829,14.63470693093013,14.678531369583656,17.957798430189147,,,16.04481615516392,14.398703251243477,17.933838936470877,16.7892817953035,12.785415848738525,17.548935470402004,26.390413563995164,,19.473327223962894,,16.849376560307668,18.272779549204852,20.39817076334729,16.001011591180223,16.604123238866034,,21.82563758574205,14.12158094301504,16.415265057374143,14.9310737302393,17.40244234928744,18.930220823502943,19.060850596992204,15.599299730298409,,20.295976693110152,21.99142807903342,15.19403735789575,18.35483625183242,14.419746258755278,16.79939971530246,14.434675562848057,15.4729116727541,15.555693567171737,18.14019444855306,,18.768352346775654,,16.11170640288955,19.15935122522818,19.683211812798312,,14.671082956208595,,15.898456543533815,18.06846767398969,20.817257329605802,20.543380693520643,22.69121658290423,17.956535152897093,21.04813610757297,27.525457014022237,16.848440515367024,17.773014213355935,16.104093367842413,11.696079275339814,16.7994249139791,13.993324810931261,19.474122310311213,18.26543434692629,16.928772894893974,17.624589105490124,15.574236181402872,18.5823334730338 -Sample_050,0,67,1,14.638370727424737,16.405949058337466,15.250502419525812,20.32176821095603,17.47034124495412,18.82461084689362,,16.85989824046187,20.55328324208922,15.627663456601512,18.3849677518202,15.267205456408677,20.560628225972266,25.028666789513665,,18.215880142493475,15.274049926633571,23.018190838317324,,19.22525584069887,28.603772571461302,16.65191139614793,15.945808513507362,19.12959196297972,13.030958884027145,23.963004614324483,19.83327211504485,14.402372734471362,15.736980831748603,14.746109866967593,11.743428581842258,13.38280038986469,15.05786434284817,17.8558770509258,,,15.289976084708396,,18.182141532741284,16.233760528817093,,17.17111875494985,26.69570886333063,,21.062588369665587,,17.42310295514816,18.22558594337121,20.561987088377066,15.427717700179077,15.065202123913433,,20.79514640000716,13.455147837617805,16.172437733380228,,18.148085828322117,19.07832348643672,17.64373620968862,16.061813337122537,,20.765408121108653,22.249482122841272,,18.911355046282896,13.767698627135491,16.194141990507134,12.29341734131341,14.82068071139786,,17.98144429562685,13.456071984362927,20.47686237022416,,16.260326349393477,18.39253701972066,19.437399427842752,15.899897968560522,14.244509158670512,,15.275572108772154,17.398536519247223,21.01628343132465,20.48287933437113,23.55327140478137,17.634067872968263,17.387999411359868,27.017366949146638,17.555312665806234,16.99881747873956,17.20762372357441,,21.412995007029238,15.774143691630009,19.53691118227992,20.339600899543843,16.434518154541163,17.584336462716397,15.572027080918572,19.067910912162592 -Sample_051,0,78,0,15.547563194147019,16.86049994185856,16.120379011794295,21.582718331722127,17.405494679361105,19.42334638706865,15.471752477587948,15.094416976196255,20.45624849438869,,18.960648408816148,14.983612699011687,19.697445278745178,24.14688955376314,,17.237339666604804,15.67062145882442,23.25234377888915,,17.888900402003536,28.143062572287146,17.341397203652747,16.37640735011764,20.19158729792329,14.573934666895898,24.16267398411683,20.416991016877823,15.445688809089033,16.854543322462398,16.99748901919271,13.540627660414794,15.927008585574232,16.081782640052882,17.98003042003764,,,,16.422229956330224,15.125263366933435,17.053800627423012,,17.7072851891665,26.299372675554118,15.140878282165463,19.396800736235203,13.526936284503153,17.069614313349007,18.531472249625043,20.7655105067222,15.266842860563427,16.12656994229522,,21.523019046760936,16.467712505723956,16.999650832968733,,16.980978037141654,19.07545189213214,19.348938417769318,15.236538046632385,,22.031776574437576,21.563597324113523,15.430119307512633,18.63691353629362,14.643564587799998,16.695799102870936,14.837935275344002,14.294992831926804,15.775926099342293,17.53467227476894,15.12212322380751,19.23271880525591,15.898724078159498,15.599883792783825,19.829201954744285,19.591184581705164,14.786278901826929,15.461526034560523,,15.830123088404928,18.239289101413483,20.512794584646137,20.291617300840205,23.342907084592692,17.766487155108997,21.002506532247324,27.704555610683304,16.33807476356721,17.54044616101453,17.358433360364376,12.518204707164703,20.934714360075326,14.628537430485304,19.288223149690722,18.15674445706274,16.765982378101473,17.531242945547472,,19.022933794795964 -Sample_052,0,71,1,14.44924879042346,17.244699175073933,15.792027378450124,21.116401394242807,18.219981028534598,19.480177320698427,,13.746983325474115,20.311264381025623,15.48531943229209,18.55061352248454,14.892399308852044,19.794485178341564,23.859497156310045,,17.008051902165047,15.764719662356242,22.76609028498367,,18.29509165473489,27.78890628377634,16.962823388919087,16.168202924573887,20.376237093700748,14.242268591636563,22.805599434852198,20.32658611248901,15.26730248572049,15.943059198795526,15.327759986990115,13.015705647543728,14.11969425412871,15.978989520583813,17.620100437073297,16.334462478861997,,16.187521376793345,,17.925208063259138,17.339697936728424,13.875376463153346,16.985852531367108,26.475061374956,15.85242111515012,19.652613167059155,,17.42014668838281,18.30881964212791,20.513245320229725,15.755172430168694,15.741081282236342,15.495979176821319,21.045978741207826,14.028900575277122,16.32145444571691,,17.90001990397197,18.801269545850413,19.098057310209683,16.09690990800393,16.23141192976878,20.469324709451747,21.83471667681008,14.730691942323364,18.815824481238497,14.594200774661923,16.69677241260659,14.504640442259264,14.8467895227715,,17.965639162530127,13.523188271617881,19.8508420936454,15.74674505014823,16.28624273100698,19.107623365200578,19.34434020573317,15.535169398038752,16.13002327618702,13.627265686628157,15.533353379842568,18.068245913646766,20.852602370911697,20.629985098866243,22.767513051305237,18.208796223669857,21.018536566183794,27.392893081261136,17.225245247918572,17.10878604609055,13.756650482437914,14.628293785876982,16.320008041735218,,19.70448204503637,18.256562737530793,16.915241248322797,17.58328457984863,15.281924368784203,19.349643663916286 -Sample_053,0,53,1,14.023298187825345,18.188997146360556,16.546866912970323,21.100991746224384,18.0828471397589,19.482218956375053,,16.739480367227195,20.28603370676596,,19.064840107179386,15.08153349901766,19.68648481823576,24.013045147443208,15.820010634849464,17.837908046354762,15.566154171254174,23.208125532104003,13.449697279371007,17.566528272941188,28.283825401064878,16.87842198784509,16.651632256228748,20.8983569895375,,23.01687985194315,20.13632342786653,14.816906792631709,17.33546055172509,15.276338846154097,14.27902956949506,15.40560114670129,15.741731538967887,17.570702426809326,,,,14.464618660372086,17.365847839382877,16.844794056237752,,17.767620944785264,26.836414487821067,14.826100092939594,19.594237799244446,13.885791964892729,17.1651595644462,18.169704693955513,20.524381736380967,15.815193979550155,15.956517074007424,15.34857256379375,22.28008357838399,15.657837854001192,16.27207216091283,15.123189173007166,18.095164390428227,18.336470465613857,19.550656731539462,15.00178905766659,15.650498831309699,21.91886796750041,21.545382133139434,,19.020334509023087,15.709701118317108,16.798497510395826,14.803828607823455,14.128929495235356,16.148766087664097,18.3044751297144,,18.618789759760027,,15.976192714625748,19.09211384035997,19.477791610913602,15.795136488876237,14.48493300504267,,16.248359179622092,18.02541265940273,20.544687392100496,20.890787131306464,23.029797435103877,18.142570947464463,19.257150851368817,27.695956454438004,16.900667749156177,17.46250913726052,16.943521329084817,13.110775761755887,21.21498916246167,15.18929899726626,19.452615787452455,17.797630359941927,17.36834845986194,17.68826258343064,15.626883621786394,18.49248206409826 -Sample_054,0,76,1,15.473391268169507,18.038771330379877,16.231233194836893,20.558305676466922,17.627778325251978,19.751917785242348,15.376018314520666,16.644942710885577,19.931789825708904,14.644023484797337,18.63085911171781,14.812705833237219,19.062901394405326,23.861947222505787,15.294348986326993,17.32778876322798,16.32489634915639,23.303476842419148,,17.8170058809182,29.130592402135502,17.15414796212673,16.849669194399763,20.429856078287283,14.38530908728832,22.103252265726884,20.614607072046237,14.417169797478191,15.948339424437567,15.805870587246966,14.10952557678594,16.266284138808416,16.09475667009492,18.30380345841625,13.998126667123234,,14.925253979921024,15.069959569329882,16.42667975713671,17.319117225668574,,17.17186824263382,26.79674547423586,15.627846106821755,20.071695738841708,13.944901472098223,17.049701838843003,18.71279502413447,20.843581630270716,15.978324850086866,16.13487279398257,15.395794812584086,21.73326270327823,14.071114682991038,18.073677097408883,15.084822171688726,17.858465975842815,17.84001451328298,19.56713213618453,,16.33775989831195,20.96388774028082,21.13077195224596,,19.106597922461898,15.334208487290152,16.376041638411728,14.336515412965799,,15.93204295765279,18.26266035240873,,18.956540027068765,16.136714407922295,,19.733962611984435,19.435404736019937,15.83813182838547,,14.230337282023019,,18.54559082014517,20.753236951717938,20.531767661401705,22.683500222810103,18.505134206270135,19.394820889235177,27.29301889205723,16.83745951191456,17.219188317953357,,13.9091187781747,15.587254583579526,14.859065525110596,19.93133546507567,18.35802186859211,17.43412271288868,17.13453285984521,15.45166641073024,18.341750089362872 -Sample_055,1,84,1,15.545639599767721,17.341093788661258,15.606477055751233,20.741254856727295,18.301632527446518,19.722989673925508,,13.861608609237456,20.261971505568972,14.527851847845984,18.45895574234047,14.16296380393292,18.479503862878698,23.576090207389154,15.48037938304943,16.646683728721875,15.95425853347767,23.470807424517144,13.319186289093611,17.813108880527917,28.657600092824566,17.04159766212354,16.29702665652649,19.239798660497346,14.68011342039874,22.62335339747909,19.10811586784657,14.873111755349386,16.872920568348476,15.753954978443419,14.61090937517732,15.573259554236657,16.017927921007782,18.264846165525437,,,15.436912034662704,,15.901435830237062,17.25160607255619,,16.831059198955376,26.490899967091895,15.030907037030234,20.767143646981026,13.424759481460866,18.472166007174078,18.010617908213494,20.97850701911564,15.777702194682641,16.14986524494912,15.6625137683047,20.89407104399114,12.918023649458853,17.464860670356835,14.890242471848369,17.54119565918222,17.918706949169607,19.374710645939974,16.462473690284583,16.31475609437702,20.803465135390095,21.225390303399877,,19.281838220386092,15.278376715202793,16.424576000955323,14.449542635072987,14.475087837582953,15.506588942582823,17.99226380938248,,19.085193314069837,15.988461238275748,16.315596818446163,19.587077711818754,19.415811385590327,16.532305624189686,15.341298108681666,,14.521296587622981,18.54433706577369,20.84929685352325,21.500537634975636,23.139880740853005,18.021183493736494,19.994587886139694,26.44263477966091,16.75322174882353,17.32366270059146,16.03133943108535,12.664667107193132,15.387722599171864,14.771962109016915,19.497701782253685,17.29707354957364,17.7552315283592,17.644071688578588,16.096005392388083,18.735127201486986 -Sample_056,1,75,0,15.16186489978015,17.208524025383255,16.38334807346016,20.872130855380966,17.19953905797487,19.93340260133011,,19.05235229134253,20.03847831159912,15.416469232115848,17.481488064730474,15.18884883764664,19.412386230834024,23.440753107565126,16.020308902881478,16.546349427618896,16.154462137086433,22.81948760307928,,18.587620049851527,27.476596293900275,17.650312780884327,16.939402196529045,20.00979257495914,13.433236107194716,22.58224938996912,19.048284973345332,14.957585200753329,16.038696155808402,15.534110371505765,13.568728178277802,14.524355071547028,15.538057583605283,17.995659859360565,15.441195251435515,,16.347291546547403,15.91032642926332,17.119223423282943,18.006990812128297,13.297435624556844,17.325830395932954,26.24760293662086,15.200783687411496,20.219624384827963,14.228522061016715,17.931095017134236,17.69790824222746,20.32079132337465,16.238952209972496,16.156054058710197,16.236380238624402,20.884084511387925,14.167389661634362,16.664347886807985,14.137072752347848,18.12201939858229,17.718803234816313,19.321001154645938,16.52352546536352,,20.66653749914462,21.46098975275492,14.964667665986525,19.048654160700984,15.62567116835783,16.82203481559397,14.9030605301983,14.516567136970517,15.548864465844995,18.266227368117846,13.474650763124135,19.46400435594765,15.216778859987835,15.73438733557406,19.355189092800604,18.972898825657044,15.833806674038895,15.688856214554363,13.6494230668535,14.953920667988754,17.890364019886093,21.1489388944388,21.209379587833485,22.873816468137406,18.30866593591621,,26.633374330511224,16.430053696185887,17.54853361377113,16.983573995216872,14.249343665555466,18.49075810686556,13.438646820794354,19.931611488863215,19.296202069748677,17.111425442783304,17.728291733552584,15.739252182305943,19.40153566236243 -Sample_057,1,79,1,14.725532268387735,16.85250179249207,16.04039458057386,20.378833935652608,18.2616557936932,19.8673890400832,,16.43312732900712,19.78421497520483,16.069697398630563,18.198273267542657,14.467664998499451,19.68250216228363,24.120728703095974,,17.142818024567504,15.795833769023945,22.77881327502968,,18.518095665684385,28.743114921288694,16.918199396411943,17.26435754936252,19.576112126074786,17.834492750151117,23.48496077719363,18.73680880626236,15.33241904897506,15.834011508480533,15.273510778944921,,13.755583214413257,15.870424738810136,17.6527750741411,,14.533074694539707,15.86401370882499,15.705215673569935,16.831073506676066,17.474856818402774,,16.839038723374628,26.131596715430856,15.478499937044926,19.51346557506002,12.856589185973723,17.741681964769935,17.217712512657304,20.732404394047226,15.815422778366905,15.174759465083426,16.09323281816251,21.197005315342583,13.598589366043958,16.608474689173818,,18.24443874898833,18.225253192511087,18.10775456671473,15.81646017632954,16.040107243896454,21.917705958228318,21.954283297698744,,19.25304228799787,15.405093408658482,17.543923073456938,14.296432592643244,14.990720477680124,,18.397034802319126,10.888877740318888,20.565689341666502,,15.537954533621038,18.23456164669253,19.355111916212277,,15.834919646613406,14.331408891050772,15.967712107555574,17.798758137220986,21.23871698046926,20.874527684637368,22.816552850327493,18.111893573135145,16.883553349036937,26.995486410146295,17.160384335955143,16.978799820501344,14.851075891715633,11.780693442749115,15.78431533583139,14.904282909536763,19.348928020100068,19.491665355496647,17.034339223153903,17.82966574004371,15.040456121384706,19.648328504325896 -Sample_058,1,68,1,15.230624597507953,17.77463466392949,16.35072260094392,20.675680892364692,18.32385301583941,20.3447266363381,14.312759174385077,15.491009232637992,19.503665628898524,15.686457781347418,17.653426129092697,14.386764124340036,19.0378508838538,23.28136367542869,16.30580195214049,17.28400084119517,16.240433536594477,22.996205376288906,13.336106204203768,17.85940160753427,28.42764801974162,17.26095139677645,16.118344993832874,20.327277694045932,14.306631639817859,22.256533656666786,20.476369958704527,15.553341138017467,15.851913134802137,15.484838256203602,13.20878238431823,14.821314465412218,16.140150283883298,18.199480497718618,,,16.77360979714173,,16.49192904186932,17.87994514627156,13.698864449879414,17.637887813173343,26.13603033847188,14.919086905403795,18.823881289260434,11.589864268726394,18.295032642212636,18.079969249764634,20.86881002923336,16.10551884002451,15.637451283159262,16.24584629015016,21.31557415490396,14.12781457976425,16.637314183933515,14.65287647560681,17.745287999047527,17.579725307013554,19.576578223068562,15.608060309157764,16.15605019994569,20.81611481804992,21.118583106437853,15.439250706630832,19.276308741145943,15.591515270186214,16.939772438419055,14.420504988311473,14.380051316106226,16.215755749405425,18.352978514615472,11.18908177959743,18.184277291436462,15.720790128049355,15.159500595575777,20.071518828023077,19.5645384155124,15.726190089541237,15.874878191006376,14.331197150563032,16.30679181959566,18.1175308683594,20.956608263743195,21.191987825538735,22.411194549681284,18.073446002799756,22.892167850450186,27.41597356314429,17.04028252942177,17.309987246730348,,14.47671654296349,15.714014249620377,13.955849237064292,19.708869287182004,17.758827475712543,17.52022360725487,17.866464801673168,15.162015239824756,19.55236351037796 -Sample_059,1,84,1,13.890451602352945,17.092036231309965,15.149254050621114,20.99854954335884,17.602348640617777,19.81818192462061,,,20.936772800791832,14.543642883048454,18.573421947570953,13.832630459946166,18.900613304870316,23.347940305033614,,18.161665344521477,15.763198180649816,23.507067034394044,12.95190630353575,19.04329367789313,28.79959546595052,16.77485088809723,16.11993246069214,19.170771671961674,,22.031490713152856,19.775413763314944,14.117281483214589,15.215740199515256,15.584105772791169,13.804111124923436,15.748521175902203,16.055205964556926,18.54080535399233,,,15.86162668702379,14.820949920501924,17.292103233963676,16.53624176041129,15.75829550759019,16.759059292669104,26.828518599091208,,19.668630748690216,13.933610790892049,16.896967406718105,18.557643306496185,20.624294475243232,15.416035427357253,16.20531002100989,15.55066166292541,20.806748236272316,13.28942906656994,16.350416149926655,15.296178959407683,17.874126800562664,17.9802346042895,18.484189471182315,,16.201103279389905,20.6877208139397,21.841764341349435,16.064519937675946,19.471193807447808,14.517135552836564,15.900951636828808,13.951678685582918,,16.132739909874402,18.294828672982323,13.754723306716125,19.02636859903784,15.786169203425073,16.32580734371764,19.45201696842568,18.933508861002153,16.662243519001358,15.596979419422986,,14.958103697211483,18.355774774252865,21.126294068176943,21.013260305027703,23.74218040617857,18.22335672511191,18.18791790137621,26.37648182270233,16.306729112443357,17.28476184267819,16.814212890213287,13.093719297920904,20.05666764527451,,19.303887469261085,19.34797516754176,17.739206231902127,17.534635826567087,16.000993545546645,18.669756618012364 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-Sample_074,1,72,0,16.021524947125272,18.102068290101297,15.932693252619975,19.71909297555469,18.21846006427327,18.792812332730286,,15.762055432333522,20.044487341366505,13.295544611106076,18.475903965840097,14.68132174533456,18.978072289277534,24.416742838351112,15.198228447076174,16.41301037814528,17.048095187585446,22.772686079409628,14.2217481779162,19.82023253477724,28.05007448970301,17.10855077736116,15.835905066433158,20.321532067681236,16.02164219188236,23.645359057923145,19.40260667897755,14.158054749517332,15.176629563155519,15.376476771870255,14.591578499875423,15.078897901630162,17.094303082718838,17.626748521894967,14.122115796680326,13.046086686179535,16.03520317043228,15.701321481492032,17.145068745297937,16.970770672079887,13.035550886565952,17.236523740974974,26.381258443716764,15.206346526086572,19.951167125462813,14.704458298487376,17.231448553045865,18.387934616306868,19.89023903866348,15.206408981885362,16.663357876221998,14.726923675268186,21.361187479164748,13.780513836283413,16.256175424477377,15.691388380160204,18.05165537186431,18.247803246100712,17.82102273950436,16.219453046356154,14.54603790496269,20.385225736194904,22.60805557011912,14.69405186722092,18.244519756118965,14.929491397209835,15.066049433681675,15.19739159267273,14.19268968525284,15.32235757482327,17.166744788202347,15.383198941604757,21.340279886965536,15.800593056412339,15.627766081935938,19.171015799781433,18.423861460301026,16.667210099786807,15.50575850185565,14.437704837947472,15.73792500706868,18.068978642755138,20.750489055070364,20.238193479048533,22.069056846330042,18.113753133161094,16.844107018609055,26.42999371473824,16.52791387465036,17.09577511121672,16.837817888754397,11.835179946132454,15.153043557169505,16.59352482358979,19.596666244485622,17.127027515466587,16.408208182004035,16.839931212955502,14.765945665672652,18.98944630113816 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-Sample_118,0,53,0,15.482489790998601,18.91511794782791,16.153801409458563,19.341507150380938,17.78364173728562,18.89319884253202,14.939788845584816,18.47663138785653,20.684456179319362,14.133102065608682,18.762742426557196,15.08897468681574,18.170712390638137,24.40918871892874,15.569138012413049,17.294532971534448,16.540635109088065,22.801589861954028,13.553796606512812,18.58281065497429,28.431182590306303,17.162161260656717,15.807041191592772,20.795977206216016,15.722475592928664,23.17124415480737,18.73154950983259,,14.777886865785508,15.160630689260845,14.332762393500968,14.61256640175003,14.652544788678888,17.239776813457723,14.290456664806172,14.18735464084314,15.86734916322912,15.486874047554066,16.616655964180335,17.429632895814308,12.939983206989805,18.188076420313813,26.296894665412957,15.526329805172155,19.2001201883389,13.901563619876962,17.869741237436052,18.576809658493875,19.651457519995052,15.446565525675155,17.501734672958342,15.703636849478423,21.843785752425298,14.14176695302992,15.429737469017647,15.8986969579434,17.95364266413591,18.424393906797473,16.5579462587541,15.601431787377795,15.252970128718871,20.267765535738857,22.46703121193932,14.918046677078031,18.434086561543516,15.568462506468274,15.442910980877253,14.52436977911728,14.528924774134905,15.71354195347646,17.251487756039904,13.635781987933857,19.682314727997454,15.154689419255345,15.748168890207447,18.868786013793002,19.067241824792102,16.64776603759649,15.57279966810384,13.751407373093517,16.05980587176918,18.099490521665757,20.543948553337874,20.528072746532015,22.423569390062674,18.164211829494025,18.738040601068306,26.602423305464196,17.2094298642407,17.459378959715536,17.586652902058923,12.830043761870565,15.0406522652014,15.709823832765533,19.500036336271236,18.826843461171794,16.593108520829215,16.859751732571056,15.781031670920301,18.46923191149954 -Sample_119,0,38,1,15.778423692103843,18.10794145240441,16.13644046702201,19.483186587115117,18.498295332728674,18.932390490986535,14.730380576286292,15.769060166891023,20.949104727469546,13.49463539938542,17.451853771028286,14.967167143700012,19.216116903985107,24.512300240600574,15.61349531803419,17.387822368090585,16.406000718657445,23.214930485114664,13.414082464551216,19.680823495610486,28.789648264424756,17.35455031205088,15.91601810910993,20.1188170617161,14.868865687011189,23.74181864966626,19.96313544597568,,15.51820951056462,14.295371405722685,13.252017287828139,13.560659592488445,14.261824057644011,17.36072989580416,14.479915546850831,13.712738149344919,16.255779797081253,15.392294622612882,16.158497977922877,16.72699713801526,12.412021255395624,17.473238647502725,26.53115037169768,14.407879740693494,19.991652538861285,13.773840458168609,17.504898253241468,17.790074212054076,20.381536878405097,15.705068408024145,16.630779809146166,15.073687229423015,21.34385312593937,12.749057782984282,15.672919164641735,15.46198308459832,17.70987030800621,18.9213475625082,17.00072558429456,16.154281954601306,14.195606951882878,20.55359566502323,23.14960061191487,14.292391710053007,17.94587743819904,14.442122553203689,15.037283183410217,15.299759026368656,15.170602072000348,14.969023539279535,17.35926832653711,14.605080445459924,18.423136176149733,15.727368031396553,15.290575343580848,18.25933898666073,18.77508245628611,16.445511760039228,15.355240048598679,14.112401325195663,15.333038075240738,17.664799028097832,20.785188029125177,20.889626316308995,21.884092152584714,18.196706123109255,18.924360108402716,26.340944314651765,16.975817275181637,17.485361324862243,17.847872462185435,,15.31791960069261,15.331472038104536,19.21599682530771,16.716818101000698,16.47541308254631,16.97115725249924,15.917910508425383,18.232991598836097 -Sample_121,1,71,1,15.287605159654548,16.492075662929544,16.202111265830393,20.13915145805367,17.763764404261167,19.291141323891907,15.157706359025225,14.19332472225243,21.096707112902905,13.17389134973213,18.538468052206948,,17.866973719989943,22.712205600197514,15.692296126882127,,16.441331034617498,23.125748624351157,14.588289163711648,20.02031076824489,28.759949122906008,17.664617525247458,16.102569740384965,20.055673664963127,16.22296024542912,21.41539414720972,19.720498431759207,14.119751237350696,,15.575486158893261,14.01804800611102,14.812488550205945,14.224379466585944,17.932705776211908,14.462711068559186,13.562993026923124,16.070419563762506,14.532685514626506,18.20544352157537,16.491717949854642,14.943716887165122,17.274309044143443,26.43136651987632,14.920817591621962,18.23209150633786,14.552049764764574,17.121348542309597,18.260425708971436,19.989800717613235,15.443248620107163,16.438867471417595,15.84547330123245,20.898404230103086,14.146248891857049,18.338724279194288,16.091208572088707,17.57782617389387,16.400806619636104,18.531618000006674,15.86411840109057,14.032571775056432,20.03376661083418,23.276554816967437,15.423439747318383,18.749736162452535,15.249756538609555,15.751805136253251,,14.781971766866707,15.189704231972613,17.50816930961107,15.06130262588535,20.38606521588508,15.684092605111076,16.78613858610949,19.98586642549675,18.192889659534327,16.381443671234678,15.45054941459409,14.176594260519053,14.326135254275448,18.11105589295896,20.862619008685133,19.79182642902472,22.456655588576364,17.586568268677087,18.978535560046385,25.591755876319162,16.554291986399573,16.757625312517707,17.168243330806355,10.60441681354643,,15.587264199286773,19.93695921455306,17.4687306745321,16.639604794624983,16.44409989432432,15.441670183416866,18.382834156292763 -Sample_122,1,58,0,13.429512735803396,16.628306469762258,15.609477711221476,20.012381237319968,18.149951585120082,18.845335946258977,15.259832177945212,15.951420704794133,21.09879272361138,13.649608245366696,18.7080492938137,13.333563349583025,18.8846785402918,23.687907333711614,15.574178309367092,17.289584132383705,15.484589987190631,23.197654202193533,15.190629646497538,19.691989562731056,28.409879563328992,17.25310794980534,15.969469699189863,20.455263874420712,16.20409377669616,21.23554638714074,18.332830260610116,14.540517108123803,15.66729218997192,15.359797406830063,13.64670602878642,14.281650345282452,13.516845543287905,17.41535662078603,14.547685326482883,,16.093838716679546,13.903723190736805,18.1647110137492,16.62031503825473,,17.608201570495023,26.822330045022902,14.79119449264145,19.057369089956907,,17.38630510911347,17.83486912378303,19.8042779692193,15.59946251069179,15.286397152542568,15.517448332432807,21.259372752582088,14.693746101277616,,15.734783514353147,17.685685680412753,18.181599061702045,18.00117519462462,15.343225166854758,14.97787722934504,20.3561727997596,23.07496558005577,15.460197019787584,19.121593431516803,15.218884825078897,15.146027425616568,14.280307061357524,14.852354436255714,16.01702636910907,17.55057747480998,15.240898304247533,21.85170043874696,16.016326794042136,15.607816115569173,19.832398675642068,18.46074071930968,,16.19699226261282,,15.458258407672936,18.383845727368573,20.08844147496866,20.085055180485398,22.112269431860426,17.869268788644884,14.819244437870045,26.269193914158237,16.672745693219287,16.72050719916212,17.152552232714953,10.118940439233317,,14.884223351211402,19.282463775618325,17.7484845282755,17.35904803144759,16.699271032909813,,18.57072095373178 -Sample_123,1,70,0,15.112651873411558,17.851097248215165,,19.686376240153358,18.871902042485974,19.569563838322356,,16.221337978994743,19.510779135399588,14.112044278465127,18.104183451134386,14.235384672227555,18.10101612001147,23.46015689039332,15.701787643907759,,17.183024090414612,22.943087286804328,14.81048181180313,17.780717268459913,28.734279101992,17.501485771825372,15.765141297578678,20.567900851386458,16.249123437565107,21.79600395052385,18.677136897980557,15.140940049937829,15.80907814142231,15.30733813244849,15.660813517497727,15.047246085496676,16.64273767644704,17.74050001061738,14.864484197442351,13.631507807439357,16.488267123766004,15.522969735642226,17.32357722232464,17.348694660484806,14.930879247283457,17.872864221569472,26.638166986607864,15.493608360812072,19.284066097731714,14.82590043841698,17.655353510219715,19.347608528547624,20.10909207727794,15.769168550205464,16.326748205952292,15.443717186560754,20.823108105359303,14.048298611675905,15.935771953582432,16.11189834756869,17.525222083742523,18.48523036046821,18.647356204237326,17.337348047724426,15.671603152061943,20.628420730964745,22.725948978733424,15.792254219995064,18.952837296039334,15.545444235702613,15.876105089596056,16.33831025527349,14.269801420283919,16.095709930626132,18.00486097439364,14.41673336897627,19.541454464783754,16.206149899366274,18.052097019995507,20.43399681573221,18.350396589883307,16.221854801686234,15.249895824059465,,15.84035707975088,18.243244019011453,20.68641118694372,20.926717294643762,22.15674692548507,18.889614527065763,16.57444570264965,25.914900527514483,16.72557356001086,17.15771730531637,15.93954926450366,13.720976699256697,13.521516335650105,,19.938144332416066,16.70034499227904,16.73618141536841,16.959676462741168,15.288641660458744,18.678450776135495 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-Sample_166,1,71,0,15.394469890775799,18.28517077338763,16.084960976171793,21.169100166211468,18.87376165801551,19.38985016408123,14.842872920145467,14.12409622063673,20.210189300823693,14.340560791299108,17.529826807328167,13.77784243052064,18.819587781071988,23.00022871879463,15.95047455834517,17.22629487919857,17.297192805023293,23.435213064823287,14.506103184307756,18.323237183063263,28.800487801486447,17.51373542572958,16.04022716959592,20.56973383223342,16.3109684250264,19.861209136469338,19.003615357052592,15.204202907471563,16.217726710283515,15.692471626824668,14.661308067790408,15.624157793680164,15.291181802797508,18.184885479801977,14.357488109551046,13.499927372252348,16.670363854892486,15.970662470672455,16.941338167923476,17.639844660260277,14.587761495815071,17.37354357571802,26.249683943574688,15.369947793694266,19.247268687586324,14.88888582055056,17.757341173813035,19.019976829764826,20.32341408495254,15.742026994653287,16.842188612205398,15.871454460367266,21.50745423314647,14.476298752769605,15.382343674057243,16.32391553269895,17.86362501485063,18.691501799870565,18.284429898257684,17.11371196632467,15.958467666725534,20.734017001780998,22.529308415694487,15.522867158328259,19.208685058676572,15.421001680250603,15.225808469973654,15.13850664679082,15.149396716805521,16.16269526361885,17.988211139470543,14.082690267589541,18.067837733024454,15.64187689458441,16.17688882846375,18.561633830353802,18.548001904660214,16.534854739381665,16.108593686857812,14.79855940858631,15.878308972551869,18.089412171175805,21.022832229014128,21.438774850481376,21.51753027115953,18.573744137310996,,26.379558845634758,16.71996049142689,17.18515203941285,15.501621828522172,13.874723442203992,13.257840996385069,16.442210022849956,19.806826494590286,16.256607653356966,17.164652250026364,16.924416926084245,15.722638288686333,19.144236730178793 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-Sample_168,1,67,1,16.15400421933937,16.845337382092886,15.929631533453323,20.137111068505,19.08043338378892,19.304041963997342,15.66175483363986,18.9215594055671,20.61360963426385,,18.288580412260625,13.860164304716296,19.178866322849146,24.93509457680552,16.253068553079476,17.455285826279543,17.115860290985754,23.238529673047033,14.541643635305693,19.58922549351885,29.084284180677347,16.57856180454103,15.82980778801632,20.286715533086785,15.668210999676939,21.922322527254202,19.42743484998805,15.62349004363492,15.730219995431892,15.341686712019515,13.867462568980867,14.515901436734163,15.085382334608036,18.00021031945083,14.271570599320265,13.651523103305589,16.069623490656596,15.766644255180259,17.505476736055453,17.09769123083071,14.752118039741882,17.09236535534648,26.53265521326658,15.337749691935622,19.065573417278124,14.405442611374227,18.233559850697098,17.946523491711456,19.96205235303479,15.932934245108203,16.477761971423025,16.4468528515935,21.185377563025256,13.788799964294048,15.54092380421956,16.81527823177597,17.585988986540002,18.67746738844754,18.172730557339307,17.266648304691895,14.951257497674,20.35025386098778,22.45934556220615,,19.165724196399115,15.419433036327092,16.276074553854645,15.109781406322893,14.138540394061513,16.264649765440705,17.694190376151457,15.40312985914108,18.258125619205657,16.068002955090332,18.129932591659443,18.486731683494614,18.468664683168946,16.202490648596704,14.993863870945694,14.30097516627743,15.414981947813114,18.520398675844692,20.537046428007795,20.49448891617815,22.22387194167916,17.381116342263297,20.28836637514894,26.23754727747028,17.16775776889703,17.268739298802103,17.209868890238926,11.183505602230372,,16.248683604463295,19.951403273197688,15.947222863436721,17.241999582677945,17.308638719740436,14.926225856677595,18.672559576615935 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-Sample_191,0,71,0,15.632176961947732,,15.789921433353106,19.845500483523807,17.826430073512785,18.649815323318432,,16.17625792915797,21.239323631255413,13.15015989632359,18.494578638907605,,18.77528414360158,25.199576536789092,15.717275622493467,,16.275546818530636,23.370950883029575,14.687259482314543,19.10415449068953,28.53730515310862,17.207294847530996,14.982138699565606,19.68568311424934,15.946084103253273,19.998309882794896,18.356760499554348,,15.161417476291472,14.935679886787291,14.43683834609833,14.99875318911409,16.176720402606428,18.03559518414735,14.54708750899273,13.18569136184114,,15.945810656293485,18.156604521465802,16.558894778310986,14.290934835690125,16.393754154519886,26.594312543285124,15.071078338764506,19.361031887645975,14.494320564190671,16.781321088831195,18.444602431255802,20.055616410425472,15.50632646938957,16.427007784354274,15.486638648355608,21.230693779219596,14.2853095040049,15.492501256508968,15.53703587905985,16.036605101957406,17.061728807864284,18.010199067473405,15.707485626769449,15.549923763655633,20.541102288688204,23.148829069909205,,18.64964826009874,14.156333868801934,15.8455980101356,,14.805555057818875,16.190072569526823,17.08146767179364,15.703922578021052,18.938184812882064,15.646292158127864,17.01790940629065,19.919943236471656,17.02330495691331,,15.187944473384666,,15.347626774858373,18.096275696549647,21.165948025139315,20.62120331313871,23.128426269348143,17.739261042529403,,25.504443962267317,16.338614664188587,16.227901745392092,17.12685678912856,13.362315751955723,,17.806511272513983,19.55301893055526,16.660316730034776,16.631749799944657,15.904942345386551,15.942371319181502,18.151118453088685 -Sample_192,1,71,1,15.636221015012945,16.685276319639925,15.571569810519016,20.662395221264454,16.424262928315517,18.411470515709148,15.8682227135286,15.676587167571244,21.74916593994766,,19.14438440587985,12.812763795961272,18.32470987917466,23.361577990840612,,,16.452387425888396,22.957716790415784,14.629599640628218,19.11304932064538,28.217282085414368,16.979102246811568,,19.745929902238668,16.100030577655115,22.13335453271354,19.179692275952487,,,16.93230298464362,14.423093719830367,14.190724581345078,14.830091068097131,17.524043307529556,14.611192340026614,14.111095224821883,14.833466119451208,14.821044837592327,19.029468381624948,15.13319851012154,14.607755625002854,16.936584296265515,26.8246865036628,14.781772512886443,19.941595271494062,,17.70879447461076,19.015181751271275,19.81028214166009,14.860949798609843,16.467203276138125,14.964798699377836,21.630347566828107,13.556495296237676,17.521011008960862,15.92025743649796,17.63593904372166,18.537087911886445,17.741123365936463,,14.068430278924852,20.496838542858256,22.64225666274488,15.103925666732655,19.056052877538093,13.755521074503976,14.809967085217044,,14.792513891899082,15.462009928663965,,,20.17576348624707,16.029771827900007,17.21237941891462,19.70138515411542,18.23622358141086,,15.830448668462042,,15.656510188018114,17.761491986771244,20.785390903097266,19.928214826508533,23.206228612900084,17.50484371315244,13.251096332266398,25.503970215139237,15.803750974886087,16.19795529694381,17.7550886696207,11.451235012309034,,17.540809255202593,18.97486748613778,17.841331306757617,15.956625987026726,15.935626657991044,15.43907426108978,18.34599531866789 -Sample_193,1,68,1,15.681842122607712,17.90675364505645,15.842764277365639,20.478255759994244,18.89742874929064,19.37968467645342,,17.575671265766555,20.276313711355677,13.931046670173682,18.525816605730363,13.859181954062986,18.46577475781329,24.11166557554111,15.851169705411282,16.43905599374788,17.09252246946197,22.80720691110985,14.979303683747553,18.60941729028533,28.705614041330183,17.289419216091368,15.356913598018707,20.511261150124806,16.20891392719764,22.856640568461902,18.58970451572848,14.421548922561444,16.159290240722907,14.955151995405275,15.035604916009518,14.932399682899879,14.492161256326154,17.677360925655293,14.743579892774841,13.344258653346747,16.684949325050635,15.835882134928674,19.491661319106232,17.42662806429838,14.913257586149717,17.54348005267515,26.74477432466239,15.488670921989797,19.20399553700917,15.355304446623762,17.65190581387881,18.654450183116126,19.873640768056813,15.749741992412108,16.4327501083179,15.475927708038235,21.022427418338037,13.698762839194824,16.11094553508411,15.108873444630863,18.367759464842596,18.643552147446833,18.415447791536163,16.719097363535436,15.465467510665952,20.325193168434975,22.04241485756814,15.656991163659448,18.797448891705077,14.806827674331446,16.133362372599557,14.992278506432683,14.407519198699056,15.788320163093374,17.75284917682767,14.471845609584106,19.73706884885469,15.498982591393103,18.36062783371524,20.0151174209147,18.246538238715512,16.816050737964364,15.41340919489405,14.554338598876413,15.60761567441882,18.218232409588243,20.46988025426994,20.670046000750016,22.427494058753638,18.751958634923763,,25.934683521828227,15.794730866989642,16.92365228245981,16.76988504766231,13.959015837555198,,,19.484868733811258,16.771116849503997,16.68974039253902,16.84002364047747,14.882860279159235,18.646307431812332 -Sample_194,1,74,0,16.15009340739948,17.700748195576157,15.785278342999913,20.163309237953037,17.845361791050696,19.132576604208296,15.0335481889729,15.393674824531317,20.86318251528731,12.817036338216134,18.365595443083567,14.191967651243166,18.383829251510054,24.830632367265626,15.675972641649489,17.227131301834557,17.52088671725147,23.069361258871428,15.242907759282586,19.49594625008018,28.53585984346982,17.06245892454293,15.45629901139419,20.417989225564018,16.60746227749873,22.465483702866386,18.90478766501128,14.811953379351799,15.637263652949171,15.455455032540883,14.995468370748393,14.910758363932258,14.42626347483064,18.062140532353904,14.625141612028756,,15.855208011616353,14.564624234835865,18.640156988769256,16.89621773366505,14.442890105120181,17.385214016618693,26.79544619192612,,19.63221091639979,15.047072143431985,17.43583491778806,19.016685549271365,20.290699777071914,15.699220401665583,15.92216625043571,14.910139745157682,21.312464217360294,14.78925054735612,16.241052708467866,15.702099850422853,17.36939366700464,19.419809769296517,18.491255665434473,17.085742150889033,15.877542049699809,20.242595697107955,23.103495123291815,15.418952912822744,18.62052032285683,15.546691377309651,15.639178611882137,16.37622397583575,14.56832831839136,16.029830791174646,17.869197140640274,15.135080474686294,20.858675590357958,15.89932465105323,14.906310966445446,19.865531097993014,17.937355679197236,,15.474621059035362,,15.931829132584523,17.901172573682274,20.80762377959434,21.017043705422626,22.801764101415188,18.340380274436725,17.471044552319835,22.906377583349613,16.568845865341174,16.478759252753377,17.25483226993483,14.465714359710795,,15.955928677460154,19.90888165152905,18.454814101388287,17.034061259931637,16.024153548933143,15.621861616805282,17.392638421346753 -Sample_195,1,62,0,15.016865573372584,17.54894170076755,14.57448543202291,19.92874759853725,18.60737671127684,19.32093630847603,,14.36169082728917,20.537035167892046,14.269273953448923,18.20436487158506,14.613979610535447,18.854685414805655,23.51619163610948,15.44361551867151,17.499038935489928,17.112078968698558,22.889132199449314,13.697903259215476,20.065188480061753,28.74844470939471,16.963189080877,16.254523785905022,20.195537869182015,16.0763788427916,22.429388606771074,17.908937067000558,,15.892045064206402,15.446146737476862,14.329563832082686,15.280989758760875,13.77403869860027,17.902523337586118,14.370459270150842,,16.786220762712837,14.890694374678178,18.477984870161585,16.771662949815774,14.196454447494386,17.006189601620793,26.797518169452896,15.559519232142886,18.173529531603926,15.397017431531554,17.24448273729567,18.34766380740182,19.58046066025636,15.354321627039237,16.87009902455154,15.17712888120088,21.1889192975023,14.33959682220833,16.163200041207283,16.325308200375215,17.731363161502983,18.58740155953609,18.350544565142595,16.60413376107173,15.463856973736117,20.575486966767873,23.030748286099428,14.56806999730102,18.860363915441564,14.632612761012329,15.16555476868021,14.620635537927773,15.090355237469755,15.691063833383609,17.64104669909975,13.847923582754852,20.558364422294492,15.832879876204439,17.738119686363518,20.054813945942982,18.559671044461407,16.15369210908001,14.79160647502959,14.01490381674922,15.11878142439738,17.923365481926165,20.77178806030114,20.82601453009888,22.361127627958865,18.392668945246825,,25.969433183212143,16.84594288944891,17.040917092288513,17.025471801103354,12.053957856035906,14.425030047000915,17.821956502358077,19.577182967342573,16.44067923479134,16.477384755720855,16.765572319024614,15.519887559933046,18.551655697448563 -Sample_196,1,69,1,16.4729759832292,16.93266288921557,15.921995524528793,19.71358285557194,17.56481725151689,18.969011063442046,,16.542585455770535,21.57362719583869,12.748285099733787,18.23677976159881,12.958021100879241,18.406940924728147,23.87217454653014,16.008969503950098,18.079964531196786,16.73038721061755,23.341002683829657,14.280388769872978,17.79303240073951,28.397515619914,17.227914668295682,15.681364858103905,20.135638057540138,16.29598789974126,20.604497352302797,18.557513250010015,,15.095163585406821,17.6784891391783,15.388864599836571,15.448075586434166,16.545217613238897,18.476811085198484,14.465319904152148,14.246826114508682,,16.788443439144157,17.05835298435601,16.960536529140796,14.665388619162187,16.529790355627927,25.60372121616244,14.821603602285567,19.86890307351759,14.538001676941063,17.32397076512084,18.882223420631153,20.156866793162145,15.907816711504621,16.78198256900693,15.618985631006726,21.221860405483845,14.338092314534737,15.042946487632172,15.942201714690984,17.876186420989086,17.566015005295583,18.06703662178005,17.08656371909812,15.461976217431527,20.12424660345499,22.948825259378225,16.30362483203676,18.92492736928875,14.648039012253538,15.834152743364175,13.026512467247683,,16.031032779610808,17.708148884037733,,21.23951535154627,15.38183916617492,17.366133283623952,20.39355045355808,18.469833190915153,,15.127411890764867,,15.122603061602042,17.629237207062136,21.1555717875429,20.8071665150462,22.84626358002268,18.425560269775115,16.158528641333174,25.3734465648829,15.970128452913452,16.266421694794072,16.992640006731254,13.967258190558095,14.84411401227548,13.172380962295382,19.332679637736117,16.849334368761966,16.609863173294624,15.219641812946103,17.236052596854634,18.430861758497223 -Sample_197,0,72,1,16.615351582736395,17.67061270709665,15.615798441491512,20.257435610364144,17.61163092156306,19.132361815779696,15.468815800174927,13.19135099471097,21.159551408766532,14.090749184205281,17.98448973561505,14.223563098948146,18.452021871605737,24.782174043522712,15.601239866829784,17.597219428703177,16.480143168255722,23.21369414989844,14.351650728725687,19.641522824472478,28.71649263479525,17.5810648143182,15.511613085686948,20.615908086507925,15.710800654413971,21.96826706250062,19.101159468031632,15.230380236393907,15.675668618223312,15.056429675067058,14.387375917553008,15.432876751320299,15.901687071596204,17.79308043999073,14.143086552193777,13.523437285681123,15.975598034218562,16.344882371249646,17.789490064491396,16.641018466259656,13.291136123394622,17.477121486200105,26.979032720985064,14.965676589234134,19.13468325533366,15.072013501944367,17.594047425812064,18.600186059513433,20.123094899530592,15.714332626705831,16.420290507401898,16.01017720860512,21.29595413950117,14.56466458443359,16.08027559822706,15.82645655016429,17.66489101843198,18.092740690969002,18.48824640368677,17.017112198820083,15.573949108682642,20.174159490967543,23.219574167039074,14.92127545794652,18.775034115476178,14.638247969811177,16.83575031988417,15.049066474525763,14.799376294961306,15.640188659297921,17.25045948182273,14.654985366211129,20.65013821352773,16.66077109160973,16.013988279593793,20.278239443533202,18.558881235757063,16.34150674318629,15.83119086329996,14.399761119798205,15.600451625269471,18.096638757615224,20.46774757549858,20.367795850914966,22.733961474533338,16.932212498765058,16.013343973490088,26.098966341649046,16.671601316533398,16.959663905811215,16.335448829739967,11.983048651596748,,15.825458344958642,19.539550035232153,,16.544918459505578,16.521527477924515,15.68969262451296,18.69355597489564 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-Sample_206,0,73,1,,16.57294176521606,16.099253089847732,20.662826876885696,19.19138774548956,18.388272491185912,16.026279265194752,15.502968704769263,21.105896522797607,,18.367208630222887,,18.507632309682702,24.380812912360593,16.283019518569546,17.282982909174823,16.446389341475957,23.421520287709537,14.62690589590397,19.50485425773043,28.66597981545914,17.25939717850066,16.42171802352834,20.47783026483433,15.716739409002432,21.65003278346235,18.708143199368518,15.855473231242039,15.701514077283596,15.50122662121272,13.845325895381606,15.059983564734521,15.968475027690571,17.963262031728117,14.785238525756393,14.053816201938519,16.382311215611747,,17.29539593040233,17.23296028288072,13.986412706075477,17.23724526991427,26.454913116812087,15.422309913381348,18.92719400413284,14.504154148626798,17.7358736071187,18.619196815146275,20.35638265285783,15.903346705958434,15.978310708548491,15.668847014053867,20.981839695753855,14.444924766587718,17.12629769222232,16.353296538357217,17.831634102937624,18.273821773680496,18.33066786847644,17.46213303040012,15.245463342776,20.56797289744124,22.745530515699972,15.42702889119605,19.22317713670382,14.848030022389757,15.459511666523113,15.13321670055898,14.576263586627272,16.419116273068358,17.62877369308021,13.345497292174555,20.02868967665063,16.634186665214607,15.183551185301555,20.389705903575255,18.73304108611418,16.388096401355742,14.709348795191609,14.578747438436224,15.458485841891427,18.70487248778997,20.752694752177813,21.026435131425156,21.554191260828976,18.201644000632914,15.514362994721315,26.051957526386882,17.000456885550406,17.258157687888378,16.58174421408839,9.747786100481987,14.372430562882586,15.566921782216601,19.3958319362863,16.975559289730707,17.109030365948197,18.056118385843803,15.282197350253966,18.686006949397548 -Sample_207,0,71,0,15.462779329422988,17.991213360692186,16.061738694582996,20.770049241114048,19.050311512163255,19.360566753736176,15.551165866866945,,20.477499017778918,13.842105245444337,18.573678850009554,14.594963972483749,18.75535409844033,23.840927907176045,15.49456753068185,18.184589665035688,17.044222168153546,23.109965957969205,14.150906717512555,18.51928518932504,28.842402238526354,17.603247363937612,15.59204635910401,21.174381710118592,16.683528278931888,21.717055197481212,18.72478715198121,15.410735739560197,15.806442732585307,16.070228572484464,15.76112651703045,15.479133394892232,14.819652386340644,17.901121555837697,14.863757331874517,13.845646723118453,16.884904870263245,14.763176495814369,15.806308101639022,17.11125031248688,14.956989177772046,18.159995716966822,26.557929684482623,15.807980606658475,18.25513881464844,14.420376612017382,17.86651017399358,19.564356410487672,20.532030304600177,15.850715453096823,16.349554987093416,15.694563741891086,21.478573379589612,14.955140197398142,16.25874457705477,15.565072784479351,17.693930567972558,18.930657219616887,17.869118521455533,17.43297905138293,15.69260326437563,20.630161788372334,22.624739465326194,15.571517386408111,19.074851446826624,15.658862159215484,16.030768151965322,14.904456846863821,14.846803866587067,15.764080294692628,17.5903436500651,14.407878185150272,19.569183104448477,15.946029739376378,18.295792751837162,19.56427243621175,18.283076197691763,16.821219858067543,14.944842775199335,14.777605385883087,16.3014074393926,18.325273883930578,20.48896910113189,21.16970882216358,22.16241868244326,18.53121926339254,16.91778516000967,23.603605859010127,16.84946542579395,17.33292679846183,15.768384050655339,13.240929739434147,13.93089855242235,15.091880193828397,19.922947193173048,16.668793572802667,16.9384143003926,17.247557866323742,14.874355729989144,19.146002401679112 -Sample_208,0,83,1,15.785848337586412,17.21608196226905,15.928611351959752,20.937931320031677,18.21571650412223,19.183228892683186,15.176228249096662,14.104039603197439,20.483012112007785,13.928564999892368,18.778347688111882,14.062229979160666,17.509659646303565,24.451948887934456,15.78869662985276,17.21698706465404,17.305327014216072,23.407205125739686,15.341298515935202,18.991405328361843,28.635805899508092,17.681597666243462,16.20276234373277,19.96691798900943,16.61323922579903,20.315350540627968,19.411134797506847,14.760967901547321,15.063240030114931,15.724792667381086,15.620852408133699,14.8426535165954,13.526811547278669,18.661746571521356,14.597891492337357,14.164923647846695,16.123920412242892,16.05033659129731,18.172855664619146,17.52712426520863,14.033256292141902,17.765197459077182,26.50070868168768,15.157436838224207,18.25613683145826,14.255677235979398,17.636815209671425,19.665721811583385,20.418489743850834,15.379490348737622,16.414724714924002,15.948887447270465,20.952618355749603,14.280312584262626,15.942484437424902,16.12299161799765,17.279244145890925,19.048526286226014,18.7074551890109,17.21290049898108,15.978929314887985,20.62638158333076,23.057150576007686,15.098256863092802,19.065174014150372,15.546327876421424,15.91169315428429,14.846670654865477,14.35491169497823,16.362642157424037,17.995399445878835,15.548566185021725,19.29158976113416,16.1847385635277,17.86044547599579,20.68920163107753,18.782009774038777,16.619445695047713,15.965122486743256,14.681286567792169,15.467640995563404,18.142084147205185,20.921167839271686,20.98469685300546,23.234787470143925,18.96408575864261,15.307735017833394,25.46181754556133,16.270587768159007,16.893344863327428,17.56034216452582,14.441839981149153,,14.26706468800057,19.830860422967554,16.25753646401774,17.155085493760062,16.352663518534502,15.471214773888873,16.85312086712736 -Sample_209,0,63,0,15.691428530692242,,15.914290869038597,20.366409466223505,19.307799904323375,19.53444561612319,15.653007510310594,13.783609168057046,21.18320798964189,13.923257293535842,18.295194955880657,13.666785170514055,16.634865986658006,24.78710212156313,16.083598622880892,16.659215702560452,16.67972351915261,23.021812281498597,15.036251602120728,19.16566501395495,28.776616062145877,17.035979207301814,16.459159422598653,20.49361825493372,16.41558962990494,21.248701553551754,19.274700192134222,,15.565213552413168,15.054126000448072,14.883746394509272,15.359328254925524,15.740677360337354,18.153290084542455,14.342535086153038,13.35592569286422,,15.939449367524764,17.278071239569293,17.734247153393536,14.329794833004238,17.252335837701164,26.17395067207999,15.2367454627256,18.132054874845423,14.13777510569626,17.474363226606183,18.291654675314707,20.24481267942653,15.756778326494905,16.183343096706036,15.471943447509231,20.89735543929346,13.992835846392907,16.792658751629748,16.381376204497577,17.626729029934747,17.526949533469466,18.53836242632315,17.506345841737062,15.841787947212133,20.626498002302984,22.825798369164072,17.25639616246646,19.489749124676102,15.361970671780185,15.702542617417203,14.275306254912445,14.731900906194687,16.217917920948786,17.884111907686393,13.0192583201727,18.66074454759917,15.88573174388313,16.707890419489814,20.403697572009055,18.39737198925449,17.146754795239794,16.145406672737007,13.997650610887316,14.735878667228357,18.401387747792704,20.79216473903947,21.03690168655737,22.55519410363064,18.441824914149432,15.275532184087263,25.852209184667146,16.390087853976567,16.804576152874446,16.33788849246753,13.627851449076102,,13.051336577841848,19.42711830402815,14.848138747050697,16.77630721959083,16.596663287535527,14.698858834460102,18.087476276067804 +Sample ID,AD,age,male,collection_site,Q6UX72,O14773,A0A0A0MQU6,P36222,P51693-2,P17174,Q9BWS9,A0A0B4J2D9,P00734,Q13433,P05154,P01258,P01593,P01834,D6RJG0,P48745,Q10472,P01023,D6R938,Q03591,P41222,Q99523,P26038,A0A1B0GV23,A0A087X1G7,A0A0B4J2B5,Q9Y6R7,Q9BT88,Q9H4D0,Q10469,Q9GZX3,Q6YHK3,P15086,Q13508,Q16658,O75874,O95206,A0A087X0D5,Q4KWH8,G3V164,O43916,Q02818,P02787,Q9Y653,A0A0G2JRQ6,P07093-2,Q9UHC6,Q99969,D6R934,E9PF59,P43234,P02794,P08294,Q8N436,P07996,A0A0A0MT66,P09382,A0A0C4DH67,P14174,O75752,F5GY87,Q96GW7,P04217-2,H3BMA1,Q9NX62,D6RGW2,P20933,Q5VUB5,P05362,P58401,Q53EL9,A0A087WW87,A0A286YFJ8,E9PMI0,G3XAK1,K4DIA0,P02452,H0YEX9,Q9BUJ0,A0A0G2JLB3,M0QZI8,O00391,P13591,Q8WXD2-2,P01042,O60279,P69905,Q8NI17,Q9BXJ3,O00468-6,A0A075B6K4,O15041,J3KNA1,A0A0C4DH33,P16870,G3V533,Q9Y5I4,P55283,A1L4H1,Q7Z4T9 +Sample_000,0,71,0,Sweden,16.04707247635549,18.411694586118436,16.381117530764204,20.948118730764158,18.657548846616937,20.232249344907675,15.500436975819781,15.408184983592198,19.869862078147364,14.999413247876399,18.510146140913214,14.795803356129424,19.502452346454668,24.013267547398048,,17.515566666817126,16.142590110695433,23.26269103027499,15.70140810518598,17.705489277516254,29.185148865135737,17.16332290616197,16.551521345046645,20.45949253047938,14.523771669917975,21.735427111658005,19.863184689831904,15.144951004168878,16.957485924969465,15.964143589687852,14.410708700523408,15.86317315525359,16.079669183220716,18.050187438775378,15.255506668788712,14.502545095790708,16.230257967007997,15.923034996705928,16.081242698805223,18.294057815447257,14.19617090340929,17.454830413599975,26.753643811951743,16.0124547265545,20.64946780131827,14.989427590517655,17.819947214683374,18.988386169843277,20.49025572414441,16.529339398134194,15.917528694348665,16.455503821468234,21.30789785377499,14.856857855313322,16.706766218155625,,18.12615162022591,16.990413119347807,19.371081073858438,,16.754503229009444,20.823983105631864,20.91463586214093,16.191654461816853,19.351351484874264,15.320157100474693,16.408485756409412,14.444290009362104,14.082726320467275,16.72023256627441,18.230487250254047,,20.571547244082275,,15.913239961249241,19.79195069714741,19.63502635378819,16.01533337576307,16.113943216522095,14.755084797360974,,18.278173071967437,20.83028018076665,21.168337301531157,22.628004028864662,18.440170385578124,17.684502408860904,27.325300522141614,16.828033216741424,17.439984037236535,16.148515062139243,14.012667670736588,20.548743608993448,14.269034910525166,20.467691861415453,18.4479991879802,17.187022923991233,17.421988133080706,15.54179840347945,19.330769884211733 +Sample_001,1,77,1,Sweden,14.457163167349366,17.86872206484739,16.196107102062623,21.083232264909235,18.446212252150982,19.77553473120793,14.760067126122257,,20.338006462421067,14.373646586583058,18.408979867371105,15.062805732293718,18.91528766567524,23.784584227952507,,,16.45274471973301,23.32969042188413,13.012270740659636,17.882905605082552,29.064397247327523,17.3356283292371,16.842324636462095,20.339268694835233,14.92844698966152,22.603142753070014,20.29933548302121,14.955378533911606,15.213013713649708,15.984004983822965,14.612025035874181,15.634540435294241,15.890606992479112,18.391993469371613,13.857308279398573,,15.020367406312829,15.563475949596256,16.37748420356844,17.582019514941113,,17.090758712539664,26.900241179361913,15.527968265191953,19.5072899283684,14.410205086712908,17.001028605427997,18.67694500024303,21.018064311096875,15.900479534549055,16.10267465441721,15.971695362106827,21.116204335556485,14.223434800056157,17.217794294984323,15.234143524217481,18.244571726040594,18.4848294077453,19.260411781812905,,16.276071429206876,20.784271797153295,21.01907638801291,,19.510162443129953,15.56596900090793,16.418042387329333,14.132914176319959,14.428466116117871,16.170800547806607,18.128584539361086,,20.443550518281345,,15.752887550779256,19.84784952900497,19.465213393869796,15.495533992460926,16.08328275219464,14.332967487162895,15.497392610631096,18.30228666031592,20.930427667893625,21.281209704828488,22.72334107777025,18.3049339206764,17.97786448055305,26.973333638812356,16.792770737395006,17.380870301494703,16.127294589210763,13.915784119378777,15.854310846712005,14.379437994754745,19.902363244938638,17.72279742303192,17.44718086568597,17.096615113973634,15.733610579765378,18.980165034933595 +Sample_002,1,75,1,Sweden,15.630937410400385,17.662383485555512,16.070892837977333,21.2055321173656,18.96711787923628,20.065793452664952,,15.361978567131006,19.81444614760232,15.120966185408399,17.9517816515895,14.218837389313455,18.738423923264893,23.136196050937343,16.358521493160715,16.87016742876413,16.097021183924326,23.127447158092124,12.675842169188241,17.54913271306828,28.21654191571416,17.178894581355394,16.259960727638802,20.12937987432253,15.19721054273952,21.805747709185145,19.59785387959316,15.113257940595108,16.7583794888436,15.928621742569739,14.21505080074079,14.780673921390276,15.793696967118905,17.893481148414267,14.143217994132748,,16.478889818650856,15.985413929124324,16.268773273679017,17.735286617238845,13.73287821407787,17.128195440897834,26.039224994405995,15.228743841704635,18.583040289180865,12.542651693133308,18.055511162053207,18.02289452354151,20.79066726978238,15.697634469131133,16.14181527703861,15.751732006725124,20.833758524557698,14.424631355074206,16.684253479537343,14.76663899856905,17.66900678509752,17.627620935072365,19.592012815223296,16.497928319866528,,20.379597562707563,20.76040849817329,,19.203107493130517,15.629885409766338,16.431002727421376,14.726204020542793,14.639222560898657,16.092998385318857,18.027147713616884,,19.571323990927578,15.341903160627663,15.74833526659247,19.29663521509667,19.36692033137389,15.62186653422836,15.837769872962486,,15.072601555385043,18.49608600062964,20.9670445072558,21.653849545359577,22.33055804991101,18.48378269472498,21.023103055211234,26.75093716070154,17.228800492323543,17.596886179090603,15.386750707222408,13.903341280917594,17.57600022192672,13.67496030953983,19.61878113588641,17.005550025915053,17.4104359530986,17.751918908624052,15.824048097249024,19.32621084149431 +Sample_003,1,72,0,Sweden,16.203920583691342,18.436588158046188,16.356063293225592,20.729036080175,18.797827732680485,20.195442349390145,15.300006024270175,,20.077729776049097,14.797979280787022,18.410693822368366,14.424061951907865,17.755812294005807,23.133438730861123,15.548134703286108,17.00624713925488,16.31120269965461,22.947878746018255,,18.29876180346154,29.107121595397928,17.59846999143334,15.70000773889132,20.305432229300465,13.951928618831703,22.021208406468524,19.42880651370279,15.030158414616302,16.344346166191933,16.152506897436798,14.692224281753745,15.908366598007012,16.55602687574677,18.50301263646123,14.43038491354068,13.228339003886488,16.676685080098736,15.740820624052066,16.217142125792048,18.36859904296439,14.160442966009073,17.50548679141393,26.788044608511264,15.494869985672036,18.653129127866837,14.55569953441145,18.017311372059226,18.520751146774938,20.229604368442068,16.297392801716878,15.617642555996929,16.092419072877632,20.7086909301372,14.239816429178942,16.60624423060296,14.571391583916869,17.65087841809303,17.02021902342293,19.494090162373503,16.839501087677977,16.235404540619086,20.961501272401442,21.45638650316427,,19.58886134853176,15.650419505322741,18.02008945148118,14.174252162648052,14.180333210422257,15.860831807652154,18.294152213985978,,19.52510173969303,,15.614200629455244,19.31573956294033,19.219918123874823,16.112352960402873,15.966927755416668,14.598344927131613,15.503200726646563,18.205831721738118,21.104386477928983,21.419841009285868,22.730267684317106,18.3805088901814,16.44472500550891,26.66099105358466,16.886392641224585,17.812391501561056,16.565036166291677,14.525815172290326,18.17279677400719,,20.170021614238728,17.211517316527765,17.545142771688965,17.483173668313594,15.515428068822281,18.953470116758414 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diff --git a/pyproject.toml b/pyproject.toml index 6087629..fb7634e 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -32,7 +32,7 @@ dependencies = [ "gseapy!=1.1.5", "kmapper", "lifelines", - "pingouin", + "pingouin<0.6.0", # ToDo: update column name changes, https://pingouin-stats.org/changelog.html#v0-6-0-february-2026 "python-louvain", "PyWGCNA!=2.2.0", # to fix. "snfpy",