stereo-seq gene map is too large

[hahia]

Hello,
I'm working with UCS in Stereo-seq, and I encountered an issue where the gene map is extremely large, with dimensions (21052, 20458, 26807) | (width, height, gene). This size is causing significant challenges in terms of data handling and processing. I was wondering if anyone has encountered a similar problem and could share some insights or solutions on how to address this?
Thank you in advance for any help or suggestions!

[chenyhvvvv]

Hi! You can first pick up highly variable gene or spatial variable gene, e.g. top 2000 genes, and than cut the whole gene map into small patch, e.g. 1200 * 1200 to run UCS.