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init alignmentSieve
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deeptools4.0.0_changes.md

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# computeMatrix
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# Changes
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## computeMatrix
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- --sortRegions 'no' option no longer exists
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- Sorting ascend / descend no longer has subsorting by position.
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- --quiet / -q option no longer exists.
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- bed files in computeMatrix no longer support '#' to define groups.
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- 'chromosome matching' i.e. chr1 <-> 1, chrMT <-> MT is no longer performed.
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# normalization
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## normalization
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Exactscaling is no longer an option, it's always performed.
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- Exactscaling is no longer an option, it's always performed.
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# Todo
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- allow multithreaded bw writing
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- properly divide region work over threads -> region sorting & taking size into account
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- calc for computeMatrix functions -> Struct / Enum
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- filehanlder bed file could all be &str, not clones
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## alignmentSieve
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- options label, smartLabels, genomeChunkLength are removed.
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- ignoreDuplicates is removed, and (if wanted) should be set by the SamFlagExclude setting.
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# Testing
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- skipZeros
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- duplicate renaming _r1, _r2, ...
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- GTF, BED3, BED6, BED12, mixedBED (?)
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- scaleRegions, un5, un3, regionbodylength, metagene
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- scaleRegions, un5, un3, regionbodylength, metagene
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## alignmentSieve
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- unmapped reads to unfiltered_out
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# Todo
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- AlignmentSieve: Shift, Bed, Optimization.
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- bamCoverage / bamCompare: filtering, extend.

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