diff --git a/CHANGELOG.md b/CHANGELOG.md
index d3d46182ea..5b30f4062d 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -34,7 +34,9 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - `opentelemetry-instrumentation-django`: improve docs for response_hook with examples of providing attributes from middlewares
   ([#3923](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3923))
 - Update for Log SDK breaking changes. Rename InMemoryLogExporter to InMemoryLogRecordExporter in several tests
-  ([#3850](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3589))
+  ([#3589](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3589))
+- opentelemetry-instrumentation: allow to skip all instrumentations loading with a wildcard
+  ([#3967](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/3967))
 
 ### Fixed
 
diff --git a/opentelemetry-instrumentation/README.rst b/opentelemetry-instrumentation/README.rst
index a342aa188c..5664bccc1d 100644
--- a/opentelemetry-instrumentation/README.rst
+++ b/opentelemetry-instrumentation/README.rst
@@ -106,6 +106,8 @@ check `here <https://opentelemetry-python.readthedocs.io/en/stable/index.html#in
 If set by the user, opentelemetry-instrument will read this environment variable to disable specific instrumentations.
 e.g OTEL_PYTHON_DISABLED_INSTRUMENTATIONS="requests,django"
 
+If the variables contains ``*`` as member no instrumentation will be enabled.
+
 * ``OTEL_PYTHON_AUTO_INSTRUMENTATION_EXPERIMENTAL_GEVENT_PATCH``
 
 If set by the user to `patch_all` , opentelemetry instrument will call the gevent monkeypatching method ``patch_all``.
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py
index fb4698a72a..fab95bf843 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py
@@ -35,6 +35,8 @@
 
 _logger = getLogger(__name__)
 
+SKIPPED_INSTRUMENTATIONS_WILDCARD = "*"
+
 
 class _EntryPointDistFinder:
     @cached_property
@@ -94,6 +96,9 @@ def _load_instrumentors(distro):
         entry_point.load()()
 
     for entry_point in entry_points(group="opentelemetry_instrumentor"):
+        if SKIPPED_INSTRUMENTATIONS_WILDCARD in package_to_exclude:
+            break
+
         if entry_point.name in package_to_exclude:
             _logger.debug(
                 "Instrumentation skipped for library %s", entry_point.name
diff --git a/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py b/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py
index e1d98669f6..c192c819b1 100644
--- a/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py
+++ b/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py
@@ -492,3 +492,54 @@ def test_entry_point_dist_finder(self):
         )
         # dist are not comparable, being truthy is enough
         self.assertTrue(new_entry_point_dist)
+
+    @patch.dict(
+        "os.environ",
+        {OTEL_PYTHON_DISABLED_INSTRUMENTATIONS: "*"},
+    )
+    @patch(
+        "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
+    )
+    @patch(
+        "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
+    )
+    def test_no_instrumentor_called_with_wildcard(self, iter_mock, mock_dep):
+        # Mock opentelemetry_pre_instrument entry points
+        # pylint: disable=too-many-locals
+        pre_ep_mock1 = Mock()
+        pre_ep_mock1.name = "pre1"
+        pre_mock1 = Mock()
+        pre_ep_mock1.load.return_value = pre_mock1
+
+        # Mock opentelemetry_instrumentor entry points
+        ep_mock1 = Mock()
+        ep_mock1.name = "instr1"
+
+        # Mock opentelemetry_instrumentor entry points
+        post_ep_mock1 = Mock()
+        post_ep_mock1.name = "post1"
+        post_mock1 = Mock()
+        post_ep_mock1.load.return_value = post_mock1
+
+        distro_mock = Mock()
+
+        # Mock entry points in order
+        iter_mock.side_effect = [
+            (pre_ep_mock1,),
+            (ep_mock1,),
+            (post_ep_mock1,),
+        ]
+        _load._load_instrumentors(distro_mock)
+
+        self.assertEqual(iter_mock.call_count, 3)
+
+        # All opentelemetry_pre_instrument entry points should be loaded
+        pre_mock1.assert_called_once()
+
+        # No instrumentations should be loaded
+        mock_dep.assert_not_called()
+        distro_mock.load_instrumentor.assert_not_called()
+        self.assertEqual(distro_mock.load_instrumentor.call_count, 0)
+
+        # All opentelemetry_post_instrument entry points should be loaded
+        post_mock1.assert_called_once()