diff --git a/reflex/istate/proxy.py b/reflex/istate/proxy.py
index 80c3f83e1fe..521174dca36 100644
--- a/reflex/istate/proxy.py
+++ b/reflex/istate/proxy.py
@@ -572,6 +572,8 @@ def __getattr__(self, __name: str) -> Any:
                 )
                 and (func := getattr(value, "__func__", None)) is not None
                 and not inspect.isclass(getattr(value, "__self__", None))
+                # skip SQLAlchemy instrumented methods
+                and not getattr(value, "_sa_instrumented", False)
             ):
                 # Rebind `self` to the proxy on methods to capture nested mutations.
                 return functools.partial(func, self)
diff --git a/tests/units/test_model.py b/tests/units/test_model.py
index 51b8982d926..e7f64f736e5 100644
--- a/tests/units/test_model.py
+++ b/tests/units/test_model.py
@@ -8,7 +8,7 @@
 import reflex.model
 from reflex.constants.state import FIELD_MARKER
 from reflex.model import Model, ModelRegistry
-from reflex.state import BaseState
+from reflex.state import BaseState, State
 from tests.units.test_state import (
     mock_app_simple,  # noqa: F401 # for pytest.mark.usefixtures
 )
@@ -240,3 +240,43 @@ async def test_upcast_event_handler_arg(handler, payload):
         assert update.delta == {
             UpcastStateWithSqlAlchemy.get_full_name(): {"passed" + FIELD_MARKER: True}
         }
+
+
+def test_no_rebind_mutable_proxy_for_instrumented_functions():
+    """Test that we don't rebind mutable proxies for instrumented functions."""
+    import sqlalchemy
+    import sqlalchemy.orm
+
+    class SABase(sqlalchemy.orm.MappedAsDataclass, sqlalchemy.orm.DeclarativeBase):
+        pass
+
+    class SAKeyword(SABase):
+        __tablename__ = "sa_keyword"
+
+        id: sqlalchemy.orm.Mapped[int] = sqlalchemy.orm.mapped_column(
+            primary_key=True, init=False, default=None
+        )
+        value: sqlalchemy.orm.Mapped[str] = sqlalchemy.orm.mapped_column(default="")
+        obj_id: sqlalchemy.orm.Mapped[int] = sqlalchemy.orm.mapped_column(
+            sqlalchemy.ForeignKey("sa_obj.id"), default=None
+        )
+
+    class SAObj(SABase):
+        __tablename__ = "sa_obj"
+
+        id: sqlalchemy.orm.Mapped[int] = sqlalchemy.orm.mapped_column(
+            primary_key=True, init=False, default=None
+        )
+        keywords: sqlalchemy.orm.Mapped[list[SAKeyword]] = sqlalchemy.orm.relationship(
+            lazy="selectin",  # codespell:ignore
+            cascade="all, delete",
+            default_factory=list,
+        )
+
+    class SAState(State):
+        sa_obj: SAObj = SAObj()
+
+    sa_state = SAState()
+    assert "sa_obj" not in sa_state.dirty_vars
+    sa_state.sa_obj.keywords.append(SAKeyword(value="test"))
+    assert "sa_obj" in sa_state.dirty_vars