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Description
NSIDES (from the Tatonetti Lab)
What it is: This is a fantastic and highly valuable database. While OFFSIDES/OnSIDES look at the effects of a single drug (N=1), NSIDES looks at the effects of taking two drugs at the same time (N=2). It identifies adverse events that are significantly more common when two drugs are taken together than would be expected from their individual side-effect profiles. It is a database of drug-drug interactions (DDIs).
Is it "off-label"?
Yes, in a sense. The vast majority of drug combinations have not been formally studied, so their interaction profiles are unknown and not on any label. NSIDES aims to discover these unknown interactions.
Fit for dbparser?
YES, ABSOLUTELY!
It is a downloadable, well-structured TSV file.
It addresses a different but critically important problem (polypharmacy).
It fits the mission of dbparser perfectly.
Adding a parseNSIDES() function would be a major contribution and would pair beautifully with parseOnSIDES().