diff --git a/changelog/68328.fixed.md b/changelog/68328.fixed.md
new file mode 100644
index 00000000000..2bffecb8483
--- /dev/null
+++ b/changelog/68328.fixed.md
@@ -0,0 +1 @@
+Fixed cp.cache_file when using Tornado > 6.4
diff --git a/salt/fileclient.py b/salt/fileclient.py
index 34f12728c8c..8b43cac21f2 100644
--- a/salt/fileclient.py
+++ b/salt/fileclient.py
@@ -744,7 +744,7 @@ def on_header(hdr):
                 # Check the status line of the HTTP request
                 if write_body[0] is None:
                     try:
-                        hdr = parse_response_start_line(hdr)
+                        hdr = parse_response_start_line(hdr.strip())
                     except HTTPInputError:
                         # Not the first line, do nothing
                         return