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10 changes: 2 additions & 8 deletions runtime/mount/agent_config/docs/atlasxomics.md
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Expand Up @@ -6,7 +6,7 @@ This is the **authoritative step-by-step pipeline** for AtlasxOmics experiment.
2. **Data Loading** - load data using **Scanpy** and display it with `w_h5`.
3. **Clustering (workflow only)** - Launch the AtlasXOmics clustering workflow using `w_workflow(wf_name="wf.__init__.opt_workflow", ...)`. Fallback to `scanpy` only if this fails.
4. **Differential Gene Activity or Motif Enrichment Comparison** - Use `w_workflow(wf_name="wf.__init__.compare_workflow", ...)`
5. **Cell Type Annotation** - assign biological meaning to clusters using gene sets.
5. **Cell Type Annotation** — Use CellGuide marker database (see {marker_gene_annotation_docs})

The section below defines detailed guidelines for each of the above steps.

Expand Down Expand Up @@ -289,13 +289,7 @@ groupings_file = LatchFile(remote_path)

### **Cell Type Annotation**

- If the dataset context is unclear, first ask the user to confirm the **organism** and **tissue type**. **Do NOT proceed** until the user has answered the question.
- **Always render a form with sensible defaults** to avoid tedious manual input. The form should support **multiple candidate cell types**, e.g. one row per cell type:
- `cell_type`: **text input**, pre-filled with a common or inferred cell type.
- `marker_genes`: **multiselect widget**, pre-populated with default marker genes for that cell type.
- You **must auto-populate all fields with reasonable defaults using domain knowledge**. Users should only adjust values if needed, not enter them from scratch.
- Add a **button** after the form to trigger gene set scoring.
- For **spatial ATAC-seq** only, infer cell identity by computing **gene activity or gene set scores** (e.g., `scanpy.tl.score_genes`) and ranking cell types based on marker enrichment.


## Data Assumptions

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